A5100361417- Renal cell carcinoma treatment
- Renal and related cancers
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- Pancreatic and Hepatic Oncology Research
- Genetic and Kidney Cyst Diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Histone Deacetylase Inhibitors Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Multiple and Secondary Primary Cancers
- Immune Cell Function and Interaction
- Economic and Financial Impacts of Cancer
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PARP inhibition in cancer therapy
Ochsner Medical Center
2011-2025
Guangxi University of Chinese Medicine
2024
South China Institute of Collaborative Innovation
2024
Ochsner Health System
2016-2024
Binzhou People's Hospital
2024
Kunming Children's Hospital
2022-2023
Kunming Medical University
2022-2023
Southeast University
2023
Southeast University
2023
Thomas Jefferson University
2022
Organ formation and regeneration require epithelial progenitor expansion to engineer, maintain, repair the branched tissue architecture. Identifying mechanisms that control will inform therapeutic organ (re)generation. Here, we discover combined KIT fibroblast growth factor receptor 2b (FGFR2b) signaling specifically increases distal during salivary gland organogenesis. FGFR2b upregulates pathway so KIT/FGFR2b signaling, via separate AKT mitogen-activated protein kinase (MAPK) pathways,...
Nile Red is a fluorescent dye used extensively to study fat accumulation in many types of cells; unfortunately protocols that work well for most cells are not effective studying drug-induced lipid cultured liver and hepatocyte-derived cell lines. Using human hepatoma (HepG2) cells, we have developed simple binding assay as screen steatosis-inducing compounds. Increases response known hepatotoxic compounds were observed after incubating treated with 1 μM several hours, washing away free Red,...
Colorectal cancer (CRC) is the third most common malignancy and second leading cause of cancer-related deaths in America. Nearly two thirds newly diagnosed CRC cases include lymph node (LN) involvement, LN metastasis one strongest negative prognostic factors for CRC. It thought that tumors contain a small population drug-resistant tumor-initiating cells (Co-TICs) may be responsible recurrence. To evaluate effects stromal on Co-TICs, we established unique xenoplant model using isolated by...
Previous investigations proposed a link between the Epstein-Barr virus (EBV) and lung cancer (LC), but results are highly controversial largely due to insufficient sample size inherent limitation of traditional viral screening methods such as PCR. Unlike PCR, current next-generation sequencing (NGS) utilizes an unbiased method for global assessment all exogenous agents within with high sensitivity specificity. In our study, we aim resolve this long-standing controversy by utilizing NGS-based...
During the last decade, mounting evidence has implicated human neurotropic virus JC in pathology of colon cancer. However, mechanisms virus-mediated oncogenesis are still not fully determined. One candidate to mediate these effects is viral early transcriptional product T-Antigen, which ability inactivate cell cycle regulatory proteins such as p53. In medulloblastomas, T-Antigen been shown bind Wnt signaling pathway protein β-catenin; however, this interaction on downstream remain unknown....
It has been reported that patients receiving renal replacement therapy (RRT), including dialysis and kidney transplantation, tend to have an increased risk of cancer; however, studies on the degree this remained inconclusive. The present meta-analysis was therefore performed quantify cancer in with RRT. Cohort assessing overall RRT published before May 29, 2015 were included following systematic searches PubMed, EMBASE reference lists retrieved. Random-effects meta‑analyses used pool...
In the oral epithelium, peripheral stores of Epstein-Barr virus (EBV) are transmitted from infiltrating B cells to epithelial cells. Once is cells, highly permissive nature this cell type for lytic replication allows amplification and exchange other hosts. Since initial transfer EBV requires transitioning B-cell a state that induces reactivation, we hypothesized there might be epithelium-specific signals allow sense appropriate environment initiate reactivation begin process. We previously...
Abstract Purpose: There are persistent racial and ethnic disparities in colorectal cancer (CRC) mortality. We examine the association between prevalence of Fusobacterium nucleatum (Fn) tumor tissue CRC-specific mortality a diverse population. Methods: The present study includes 569 African American, Alaska Native, Latinx, non-Hispanic White adults with stage I-III CRC who were part Translational Research Program Colorectal Cancer Disparities (TRPCD). 188 patients died matched to 381 did not...
<p>Supplementary Figure S4. CK5 and CK17 do not predict treatment response or time to recurrence. A) Combining GATA6 IHC does overall survival. B) high, low tumors display improved survival compared low, high tumors. C) Kaplan-Meier curves for positive negative treated with first-line gemcitabine chemotherapy. D) E) status F) show longer recurrence than tumors, the opposite phenotype expected from basal subtype.</p>
<p>Supplementary Figure S1. Example images of IHC FFPE samples. A) HMGA2 positive glands. B) GATA6 Scale bars = 50 μm.</p>
<p>Supplementary Figure S3. Consort Diagram and Mixed Populations. A) diagram of analyzed samples. For survival analyses, all patients with intact cores (n = 491) were assessed. treatment response further subdivided by type chemotherapy received, neoadjuvant-treated samples considered separately 51). B) (HMGA2+ GATA6+) double negative (HMGA2- GATA6-) populations show intermediate between basal classical tumors.</p>
<p>Supplementary Figure S6. GATA6 expression predicts chemotherapy response to GnP but not mFFX. A) GATA6low metastatic tumors have significantly worse overall survival when treated with combination first-line chemotherapy. B) status does predict patients receive first line mFFX chemotherapy.</p>
<div>AbstractPurpose:<p>The purpose of this study was to establish HMGA2 as a marker basal-like disease in pancreatic ductal adenocarcinoma (PDAC) and explore its use biomarker for prognosis treatment resistance.</p>Experimental Design:<p>We identified high-mobility group A2 (HMGA2) protein expression basal PDAC cells single-cell RNA sequencing (RNA-seq) atlas 172 patient samples. We then analyzed expression, along with the classic GATA-binding factor 6 (GATA6),...