A5023320487- Genetics, Bioinformatics, and Biomedical Research
- Diphtheria, Corynebacterium, and Tetanus
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Protein Structure and Dynamics
- Biofuel production and bioconversion
- Machine Learning in Bioinformatics
- Bacterial Identification and Susceptibility Testing
- Education and Digital Technologies
- SARS-CoV-2 and COVID-19 Research
- Science and Education Research
- Veterinary medicine and infectious diseases
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Scientific Computing and Data Management
- Monoclonal and Polyclonal Antibodies Research
- Enzyme Structure and Function
- Biomedical and Engineering Education
- Biotin and Related Studies
- Advanced Proteomics Techniques and Applications
- Enzyme Catalysis and Immobilization
- Biotechnology and Related Fields
Universidade Federal de Minas Gerais
2015-2024
eBay (Ireland)
2023
Federal University of São João del-Rei
2022
Universidade Federal do Rio Grande
2022
Universidade de São Paulo
2022
Secretaria do Meio Ambiente
2021
Visa (United Kingdom)
2021
Google (United States)
2021
Protein-peptide interactions play a fundamental role in wide variety of biological processes, such as cell signaling, regulatory networks, immune responses, and enzyme inhibition. Peptides are characterized by low toxicity small interface areas; therefore, they good targets for therapeutic strategies, rational drug planning protein Approximately 10% the ethical pharmaceutical market is protein/peptide-based. Furthermore, it estimated that 40% mediated peptides. Despite fast increase volume...
DATA REPORT article Front. Bioinform., 16 February 2023Sec. Integrative Bioinformatics Volume 3 - 2023 | https://doi.org/10.3389/fbinf.2023.1103103
SARS-CoV-2 is the virus responsible for a respiratory disease called COVID-19 that devastated global public health. Since 2020, there has been an intense effort by scientific community to develop safe and effective prophylactic therapeutic agents against this disease. In context, peptides have emerged as alternative inhibiting causative agent. However, designing bind efficiently still open challenge. Here, we show algorithm peptide engineering. Our strategy consists of starting with whose...
Lactococcus lactis subsp. NCDO 2118 is a nondairy lactic acid bacterium, xylose fermenter, and gamma-aminobutyric (GABA) producer isolated from frozen peas. Here, we report the complete genome sequence of L. 2118, strain with probiotic potential activity.
β-Glucosidases are enzymes with high importance for many industrial processes, catalyzing the last and limiting step of conversion lignocellulosic material into fermentable sugars biofuel production. However, β-glucosidases inhibited by concentrations product (glucose), which limits production on an scale. For this reason, structural mechanisms tolerance to inhibition have been target several studies. In study, we performed in silico experiments, such as molecular dynamics (MD) simulations,...
Abstract Corynebacterium pseudotuberculosis strain VD57 (Cp_VD57), a highly virulent, nonmotile, non-sporulating, and mesophilic bacterium, was isolated from goat’s granulomatous lesion in the municipality of Juazeiro, Bahia State, Brazil. Here, we describe set features strain, together with details its complete genome sequence annotation. The comprises 2.5 Mbp long, single circular 2,101 protein-coding genes, 12 rRNA, 49 tRNA 47 pseudogenes G + C content 52.85 %. Genetic variation detected...
Abstract The advent of the high‐throughput next‐generation sequencing produced a large number biological data. Knowledge discovery from huge amount available data requires researchers to develop solid skills in biology and computer science. As majority Bioinformatics professionals are either science or life sciences graduates, teach students computational has become usual. In this article, we reported experience teaching programming for students. Our strategy is composed by explaining basic...
Bioinformatics research depends on high-quality databases to provide accurate results. In silico experiments, correctly performed, may prospect novel discoveries and elucidates pathways for biological experiments through data analysis in large scale. However, most have presented mistakes, such as incorrectly classified or incomplete information. Also, sometimes, mining algorithms cannot treat these errors, leading serious problems the analysis. Manual curation of extracted from literature is...
β-glucosidases (EC 3.2.1.21) have been described as essential to second-generation biofuel production. They act in the last step of lignocellulosic saccharification, cleaving β − 1,4 glycosidic bonds cellobiose produce two molecules glucose. However, strongly inhibited by glucose, causing an increment concentration. Also, is inhibitor other enzymes used this process, such exoglucanases and endoglucanases. Hence, engineering thermostable glucose-tolerant has targeted many studies. In study,...
With the use of genetic engineering, modified and sometimes more efficient enzymes can be created for different purposes, including industrial applications. However, building depends on several in vitro experiments, which may result process being expensive time-consuming. Therefore, computational approaches could reduce costs accelerate discovery new technological products. In this study, we present a method, called structural signature variation (SSV), to propose mutations improving...
Evolutionarily related proteins can present similar structures but very dissimilar sequences. Hence, understanding the role of inter-residues contacts for protein structure has been target many studies. Contacts comprise non-covalent interactions, which are essential to stabilize macromolecular such as proteins. Here we show VTR, a new method detection analogous in pairs. The VTR web tool performs structural alignment between and detects interactions that occur regions. To evaluate our tool,...
The newest technologies for DNA sequencing have led to the determination of primary structure genomes organisms, mainly prokaryotes, with high efficiency and at lower costs.However, presence regions repetitive sequences, in addition short reads produced by Next-Generation Sequencing (NGS) platforms, created a lot difficulty reconstructing original genome silico.Thus, even today, assembly continues be one major challenges bioinformatics specifically when sequences are considered.In this...
Abstract Background Protein engineering has many applications for industry, such as the development of new drugs, vaccines, treatment therapies, food, and biofuel production. A common way to engineer a protein is perform mutations in functionally essential residues optimize their function. However, discovery beneficial proteins complex task, with time-consuming high cost experimental validation. Hence, computational approaches have been used propose insights experiments narrowing search...
Studies have detected mis-assemblies in genomes of the species Corynebacterium pseudotuberculosis. These new discover been possible due to evolution Next-Generation Sequencing platforms, which provided sequencing with accuracy and reduced costs. In addition, improving techniques for construction high genomic maps, example, Whole-genome mapping (WGM) (OpGen Inc), allow high-resolution assembly that can detect large rearrangements.In this work, we present resequencing pseudotuberculosis strain...
Streptococcus agalactiae, also referred to as Group B Streptococcus, is a frequent resident of the rectovaginal tract in humans, and major cause neonatal infection. The pathogen can infect adults with underlying disease, particularly elderly immunocompromised ones. In addition, S. agalactiae known fish pathogen, which compromises food safety represents zoonotic hazard. This study provides valuable structural, functional evolutionary genomic information human serotype Ia (ST-103) GBS85147...
The evolution of Next-Generation Sequencing (NGS) has considerably reduced the cost per sequenced-base, allowing a significant rise sequencing projects, mainly in prokaryotes. However, range available NGS platforms requires different strategies and software to correctly assemble genomes. Different are necessary properly complete an assembly project, addition installation or modification various software. This users have expertise these command line scripting experience on Unix platforms,...
Abstract Β-glucosidases are key enzymes used in second-generation biofuel production. They act the last step of lignocellulose saccharification, converting cellobiose glucose. However, most β-glucosidases inhibited by high glucose concentrations, which turns it a limiting for industrial Thus, have been targeted several studies aiming to understand mechanism tolerance, pH and thermal resistance constructing more efficient enzymes. In this paper, we present database β-glucosidase structures,...