A5081381090- Diphtheria, Corynebacterium, and Tetanus
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Neonatal and Maternal Infections
- Veterinary medicine and infectious diseases
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Bacterial biofilms and quorum sensing
- Botulinum Toxin and Related Neurological Disorders
- Antibiotic Resistance in Bacteria
- Oral microbiology and periodontitis research
- Healthcare Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pneumonia and Respiratory Infections
- Escherichia coli research studies
- Vibrio bacteria research studies
- Glycosylation and Glycoproteins Research
- Essential Oils and Antimicrobial Activity
- Historical Medical Research and Treatments
- Plant and fungal interactions
- Pharmacological Effects of Natural Compounds
- Actinomycetales infections and treatment
Universidade do Estado do Rio de Janeiro
2016-2025
Universidade Federal do Rio de Janeiro
1999-2025
Ministério da Saúde
2014-2025
Faculdade de Ciências Médicas de Minas Gerais
2003-2023
Health Foundation
2020
Anhembi Morumbi University
2020
National Council for Scientific and Technological Development
2019
Hospital Universitário Pedro Ernesto
2013-2019
Fundação Saúde
2018
Fundação Faculdade de Medicina
2010
Corynebacterium diphtheriae is one of the most prominent human pathogens and causative agent communicable disease diphtheria. The genomes 12 strains isolated from patients with classical diphtheria, endocarditis, pneumonia were completely sequenced annotated. Including genome C. NCTC 13129, we herewith present a comprehensive comparative analysis 13 first characterization pangenome species diphtheriae. Comparative genomics showed extensive synteny revealed core consisting 1,632 conserved...
Animal models are widely used in scientific research order to obtain information from a whole organism under specific set of experimental conditions. Various lineages mice have been investigate diseases and new therapeutic strategies, and, consequently, hematological biochemical tests these laboratory animals essential validate studies. Our study seeks establish reference values for parameters four mice.
Abstract Background Corynebacterium ulcerans has been detected as a commensal in domestic and wild animals that may serve reservoirs for zoonotic infections. During the last decade, frequency severity of human infections associated with C. appear to be increasing various countries. As knowledge genes contributing virulence this bacterium was very limited, complete genome sequences two strains metropolitan area Rio de Janeiro were determined characterized by comparative genomics: 809...
The adaptability of pathogenic bacteria to hosts is influenced by the genomic plasticity bacteria, which can be increased such mechanisms as horizontal gene transfer. Pathogenicity islands play a major role in this type transfer because they are large, horizontally acquired regions that harbor clusters virulence genes mediate adhesion, colonization, invasion, immune system evasion, and toxigenic properties acceptor organism. Currently, pathogenicity mainly identified silico based on various...
Corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. However, little known about its virulence factors may contribute to healthcare-associated infections (HAIs). We investigated the biofilm production on abiotic surfaces of multidrug-resistant (MDR) and multidrug-susceptible (MDS) strains C. pulsed-field gel electrophoresis types I-MDR, II-MDR, III-MDS IV-MDS isolated during outbreak in Rio de Janeiro, Brazil. The results showed was able adhere...
Corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. Here, we document outbreak caused by multidrug-resistant (MDR) C. in Rio de Janeiro, Brazil. identification was confirmed 16S rRNA and rpoB gene sequencing. Fifteen strains were isolated from adults (half whom 50 years age older). mostly pure culture tracheal aspirates patients undergoing endotracheal intubation procedures. The analysis pulsed-field gel...
SUMMARY We describe microbiological, clinical and epidemiological aspects of a diphtheria outbreak that occurred in Maranhão, Brazil. The majority the 27 confirmed cases partially ( n = 16) or completely 10) immunized children 26). Clinical signs characteristic symptoms such as cervical lymphadenopathy pseudomembrane formation were absent 48% 7% cases, respectively. Complications paralysis lower limbs observed. Three resulted death, two them children. Microbiological analysis identified...
Corynebacterium striatum is an emerging multidrug-resistant (MDR) pathogen associated with immunocompromised and chronically ill patients, as well nosocomial outbreaks. In this study, we characterized 23 MDR C. isolated of bloodstream catheter-related infections from a hospital Rio de Janeiro.C. isolates were identified by 16S rRNA rpoB genes sequencing. The dissemination these was accomplished pulsed-field gel electrophoresis (PFGE). All submitted to antimicrobial susceptibility testing...
This investigation aimed to isolate enteric rods from subgingival sites of patients presenting chronic periodontitis lesions, and assess antimicrobial resistance expression hydrolytic enzymes.Enterobacteriaceae were isolated 20% patients, assayed for susceptibility enzymes with specificity different substrates. Isolates comprised seven Enterobacter cloacae (43.75%), five Serratia marcescens (31.25%), one Klebsiella pneumoniae (6.25%), aerogenes Pantoea agglomerans Citrobacter freundii...
Invasive diseases caused by Corynebacterium diphtheriae have been described increasingly. Several reports indicate the destructive feature of endocarditis attributable to nontoxigenic strains. However, few dealt with pathogenicity invasive The present investigation demonstrates a phenotypic trait that may be used identify potentially study also draws attention clinical and microbiological aspects observed in 5 cases due C. occurred outside Europe. Four female school-age children (7-14 years)...
Background Nocardia sp. causes a variety of clinical presentations. The incidence nocardiosis varies geographically according to several factors, such as the prevalence HIV infections, transplants, neoplastic and rheumatic diseases, well climate, socio-economic conditions laboratory procedures for detection identification. In Brazil paucity reports infections suggests that this genus may be underestimated cause human diseases and/or either neglected or misidentified in specimens. Accurate...
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen able to survive and multiply within macrophages. Several mechanisms allow this bacterium escape macrophage microbicidal activity. Mtb may interfere with the ability of mouse macrophages produce antibactericidal nitric oxide, by inducing expression arginase 1 (Arg1). It remains unclear whether pathway has a role in humans infected Mtb. In study, we investigated Arg1 granulomas human lung tissues from patients tuberculosis. We show...
Corynebacterium diphtheriae, ulcerans and pseudotuberculosis constitute a group of potentially toxigenic microorganisms that are related to different infectious processes in animal human hosts. Currently, there is lack information on the prevalence disease caused by these pathogens, which partially due reduction frequency routine laboratory testing. In this study, multiplex polymerase chain reaction (mPCR) assay can simultaneously identify determine toxigenicity corynebacterial species with...
Coronavirus disease 2019 (COVID-19) is caused by the new coronavirus 2 (severe acute respiratory syndrome - SARS-CoV-2). Long COVID a condition associated with persistent COVID-19 symptoms and/or emerging symptoms. Telomeres are specialised structures for genome protection at end of chromosomes and telomerase enzyme that synthesises telomere DNA. Patients were recruited Pedro Ernesto University Hospital (HUPE) in Rio de Janeiro, Brazil, main purpose investigating association between length...
Corynebacterium diphtheriae still represents a global medical challenge, particularly due to the significant number of individuals susceptible diphtheria and emergence non-toxigenic strains as causative agents invasive infections. In this study, we characterized clinical microbiological features what believe be first case C. infection percutaneous nephrostomy catheter insertion site in an elderly patient with fatal bladder cancer. Moreover, demonstrated potential role adherence, biofilm...
The increasing problems with multidrug resistance in relation to Corynebacterium, including C. diphtheriae, are examples of challenges confronting many countries. For this reason, Brazilian diphtheriae strains were evaluated by the E-Test for their susceptibility nine antibacterial drugs used therapy. Resistance (MIC < 0.002; 0.38 µg/ml) penicillin G was found 14.8% tested. Although erythromycin (MIC90 0.75 and azithromycin 0.064 active against study, 4.2% showed decreased 1.0 erythromycin....
ABSTRACT Iron limitation may cause bacterial pathogens to grow more slowly; however, it also stimulate these microorganisms produce greater tissue damage, given that many virulence factors are controlled by the iron supply in environment. The present study investigated influence of low availability on expression proteins and surface sugar residues two toxigenic strains Corynebacterium diphtheriae subsp. mitis evaluated their adherence human group B erythrocytes HEp-2 cells. A comparison was...