A5022352214- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- Parasites and Host Interactions
- Dengue and Mosquito Control Research
- Iron Metabolism and Disorders
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Child Nutrition and Water Access
- Parasite Biology and Host Interactions
- Viral Infections and Vectors
- Hemoglobinopathies and Related Disorders
- COVID-19 epidemiological studies
- Zoonotic diseases and public health
Centre National de Recherche et de Formation sur le Paludisme
2012-2024
Université Joseph Ki-Zerbo
2021-2024
Joseph Ayo Babalola University
2023-2024
Liverpool School of Tropical Medicine
2012-2015
Centre Muraz
2009-2014
Institut de Recherche en Sciences de la Santé
2010-2014
Malaria control is dependent on insecticides. Increases in prevalence of insecticide resistance malaria vectors across Africa are well-documented. However, few attempts have been made to quantify the strength this and link it effectiveness tools. Using quantitative bioassays, we show that Burkina Faso pyrethroid Anopheles gambiae mosquitoes has increased intensity recent years now exceeds 1,000-fold. In laboratory assays, level renders insecticides used impregnate bed nets ineffective. Thus,...
Since 2011, the level of pyrethroid resistance in major malaria mosquito, Anopheles coluzzi, has increased to such an extent Burkina Faso that none long lasting insecticide treated nets (LLINs) currently use throughout country kill local mosquito vectors. We investigated whether this observed increase was associated with transcriptional changes field-caught coluzzi using two independent whole-genome microarray studies, performed 2011 and 2012. Mosquitoes were collected from south-west 2012...
Western Africa is vulnerable to arboviral disease transmission, having recently experienced major outbreaks of chikungunya, dengue, yellow fever and Zika. However, there have been relatively few studies on the natural history two human arbovirus vectors in this region, Aedes aegypti Ae. albopictus, potentially limiting implementation effective vector control. We systematically searched for reviewed relevant behaviour ecology albopictus Africa, published over last 40 years. identified 73...
This study reports on the distribution of pyrethroid and DDT resistance L1014F knockdown (kdr) mutation in Anopheles gambiae s.l. populations from 21 localities three different climatic zones Burkina Faso August to October 2006. The susceptibility these was assessed by bioassay using (4%), permethrin (1%) deltamethrin (0.05%). Anophelesgambiae were resistant both Sudanian regions but susceptible central sahelian areas at all sites except Orodara, although mortality values some close...
In the city of Bobo-Dioulasso in Burkina Faso, Anopheles arabiensis has superseded gambiae s.s. as major malaria vector and larvae are found highly polluted habitats normally considered unsuitable for mosquitoes. Here we show that An. s.l. adults emerging from a site centre (Dioulassoba) have high prevalence DDT resistance (percentage mortality after exposure to diagnostic dose=65.8% dry season 70.4% rainy season, respectively). An investigation into mechanisms responsible an unexpectedly...
An entomological survey was carried out at 15 sites dispersed throughout the three eco-climatic regions of Burkina Faso (West Africa) in order to assess current distribution and frequency mutations that confer resistance insecticides An. gambiae s.l. populations country. Both knockdown (kdr) mutation variants (L1014F L1014S), pyrethroid insecticides, were identified concomitant with ace-1 G119S confirming presence multiple mechanisms complex Faso. Compared last survey, L1014F kdr appears...
The efficacy of long-lasting insecticidal nets (LLINs) in preventing malaria Africa is threatened by insecticide resistance. Bioassays assessing 24-hour mortality post-LLIN exposure have established that resistance to the concentration pyrethroids used LLINs widespread. However, although mosquitoes may no longer be rapidly killed LLIN exposure, a delayed effect has been shown reduce transmission potential exposed nets. This postulated partially explain continued against pyrethroid-resistant...
Abstract Background Historical studies have indicated that An. gambiae s.s. is the predominant malaria vector species in Bobo-Dioulasso second biggest city of Burkina Faso (West Africa). However, over last decade, arabiensis appears to be replacing as most prevalent this urban setting. To investigate transition more detail present study aims provide an update on composition Bobo-Dioulasso, and also Plasmodium infection rates susceptibility insecticides local s.l. population. Methods An...
Before the release of genetically-modified or sterile male mosquitoes in an attempt to control local populations malaria vectors, it is crucial determine traits involved mating success. The effects size and age as determinants success Anopheles gambiae s.s. were measured field under laboratory conditions Burkina Faso. First, body sizes (estimated by wing length) mating, swarming, indoor-resting compared over a 3-yr period (2006–2009) from July October Soumousso Vallée du Kou, two villages...
Abstract Malaria control is dependent on the use of longlasting insecticidal nets (LLINs) containing pyrethroids. A new generation LLINs both pyrethroids and synergist piperonyl butoxide (PBO) has been developed in response to increasing pyrethroid resistance African malaria vectors, but questions remain about performance these areas where levels are very high. This study was conducted two settings southwest Burkina Faso, Vallée du Kou 5 Tengrela, Anopheles gambiae s.l. (Diptera: Culicidae)...
Abstract The response to recent dengue outbreaks in Burkina Faso was insecticide‐based, despite poor knowledge of the vector population's susceptibility insecticides used. Here, we report on main insecticide classes and identify important underlying mechanisms Aedes aegypti populations Ouagadougou Banfora, 2019 2020. Wild Ae. were tested as adults WHO bioassays then screened real time melting curve qPCR analyses genotype F1534C, V1016I, V410L kdr mutations. showed moderate resistance 0.1%...
Pyrethroid resistance in the Anopheles vectors of malaria is driving an urgent search for new insecticides that can be used proven vector control tools such as insecticide treated nets (ITNs). Screening potential requires access to stable colonies predominant species contain major pyrethroid mechanisms circulating wild populations. Southwest Burkina Faso apparent hotspot emergence gambiae complex. We established from larval collections across this region and characterised phenotype...
Abstract Background Long-lasting insecticidal nets (LLINs) treated with pyrethroids are the foundation of malaria control in sub-Saharan Africa. Rising pyrethroid resistance vectors, however, has driven development alternative net formulations. Here durability polyethylene a novel combination pyrethroid, permethrin, and insect juvenile hormone mimic, pyriproxyfen (PPF), compared to standard permethrin LLIN, was assessed rural Burkina Faso. Methods A compound-randomized controlled trial...
The molecular form composition of Anopheles gambiae Giles s.s. (Diptera: Culicidae) mating swarms and the associated pairs (copulae) were investigated during two rainy seasons (July to October, 2005 July November, 2006) in villages Soumousso Vallée du Kou (VK7). Although habitats these differ markedly, sympatric populations M S forms An. occur both places periodically. main aim was assess degree which mate assortatively. In Soumousso, a wooded savannah habitat, majority swarm samples...
Abstract Background Outbreaks of dengue fever caused by viruses transmitted Aedes aegypti mosquitoes are repeated occurrences in West Africa. In recent years, Burkina Faso has experienced major outbreaks, most notably 2016 and 2017 when 80% cases were recorded Ouagadougou City (Central Health Region). order to better understand the ecology this vector provide information for use developing control measures, a study on characteristics container breeding sites productivity such sites, as...
Experimental hut trials (EHTs) are used to evaluate indoor vector control interventions against malaria vectors in a controlled setting. The level of variability present the assay will influence whether given study is well powered answer research question being considered. We utilised disaggregated data from 15 previous EHTs gain insight into behaviour typically observed. Using simulations generalised linear mixed models obtain power estimates for EHTs, we show how factors such as number...
Abstract Background Several cases of malaria are frequently recorded during the dry period in Ouagadougou town (Burkina Faso). This has led to design a series studies focusing on both parasitological and entomological investigations intended provide relevant health data risk local transmission according way urbanisation. Methods A cross-sectional survey was carried out various districts April October 2006. Adult vectors were collected using CDC traps indoor insecticide spraying performed...
The Anopheles gambiae complex consists of multiple morphologically indistinguishable mosquito species including the most important vectors malaria parasite Plasmodium falciparum in sub-Saharan Africa. Nine cryptic have been described so far within complex. ecological, immunological and reproductive differences among these will critically impact population responses to disease control strategies environmental changes. Here, we examine whole-genome sequencing data from a longitudinal study...
A three-year longitudinal study was conducted in four sentinel sites from different ecological settings Burkina Faso, between 2008 and 2010 to identify changes insecticide resistance within Anopheles gambiae complex species based on larval collection. During this study, adult mosquitoes were also collected indoor outdoor using several methods of The present reports the diversity malaria vectors 1014F-genotype collection investigates association sporozoite rate. Adult July August...
One of the greatest challenges in reducing malaria transmission sub-Saharan Africa is high degree plasticity behaviour and ecology members Anopheles gambiae complex, which includes most efficient vectors globally. For example, areas West Africa, sympatric populations M S molecular forms An. s.s. have diverged into recognized species (An. coluzzii Coetzee & Wilkerson sp.n. nominative species, s.s., respectively) through ecological speciation. Whereas main breeding sites for continue to be...
Abstract Arboviral diseases such as dengue, Zika and chikungunya transmitted by Aedes mosquitoes have been reported in 34 African countries. Available data indicate that recent years there dengue outbreaks the West Africa subregion, countries including Côte d’Ivoire, Burkina Faso, Gabon, Senegal, Benin. These viral are causing an increased public health burden, which impedes poverty reduction sustainable development. surveillance control capacity, key to reducing prevalence of arboviral...
Abstract Background Progress in controlling malaria has stalled recent years. Today the burden is increasingly concentrated a few countries, including Burkina Faso, where not declining. A cohort study was conducted to identify risk factors for infection children southwest an area with high insecticide-treated net (ITN) coverage and insecticide-resistant vectors. Methods Incidence of Plasmodium falciparum measured 252 aged 5 15 years, using active passive detection, during 2017 transmission...