A5043223366- Mosquito-borne diseases and control
- Malaria Research and Control
- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Parasite Biology and Host Interactions
- Viral Infections and Vectors
- Oral microbiology and periodontitis research
- SARS-CoV-2 detection and testing
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Insect symbiosis and bacterial influences
- Digital Imaging for Blood Diseases
- Vector-borne infectious diseases
- Immune responses and vaccinations
- Insect Resistance and Genetics
- Hepatitis C virus research
- Oral Health Pathology and Treatment
- HIV/AIDS Research and Interventions
- Computational Drug Discovery Methods
- Infection Control and Ventilation
- Vector-Borne Animal Diseases
- HIV, Drug Use, Sexual Risk
Noguchi Memorial Institute for Medical Research
2017-2025
University of Ghana
2017-2025
La Trobe University
2023-2024
University of Glasgow
2023
University of Science and Technology
2020
Kwame Nkrumah University of Science and Technology
2020
Komfo Anokye Teaching Hospital
2020
Kwame Nkrumah University
2020
Liverpool School of Tropical Medicine
2018
Asymptomatic Plasmodium infections significantly drive malaria transmission and impact control elimination strategies, but are largely uncharacterized. We investigated the prevalence risk factors of asymptomatic to inform strategies in Ghana.Five cross-sectional surveys were conducted at end peak season (August-September) on 4892 school children aged between 6 14 years two distinct ecological settings Ghana 2013 2017. The study sites Begoro (forest ecology) Cape Coast (coastal ecology)....
Despite years of preventive interventions, Mother-to-child transmission (MTCT) HIV remains high in low- and middle-income countries. This study aimed to identify risk factors associated with MTCT Ghana. A 1:1 unmatched case-control was conducted among HIV-infected mothers their exposed children (184 cases 184 controls) using data from the 2021–2022 HIV-Positive Babies Audit by National AIDS/STI Control Programme Only variables missing values ≤ 5% were included univariable logistic regression...
A significant proportion of SARS-CoV-2 infections in Africa were identified as asymptomatic. With the surge Omicron variant, asymptomatic participants epidemiological surveys key to accurately estimating seroprevalence and true population. This study assessed seroprevalence, active infections, circulating variants Accra, Ghana, during wave. Secondary objectives included assessing association between sociodemographic factors, vaccination, adherence recommended prevention control measures. We...
A key drawback to monitoring the emergence and spread of antimalarial drug resistance in sub-Saharan Africa is early detection containment. Next-generation sequencing methods offer resolution, sensitivity, scale required fill this gap by surveilling for molecular markers resistance. We performed targeted using inversion probes interrogate five Plasmodium falciparum genes ( pfcrt , pfmdr1 pfdhps pfdhfr pfk13 ) implicated chloroquine, sulfadoxine-pyrimethamine (SP), artemisinin two sites Ghana.
Abstract A vertically transmitted microsporidian, Microsporidia MB , with the ability to disrupt Plasmodium development was reported in Anopheles arabiensis from Kenya, East Africa. To demonstrate its range of incidence, archived DNA samples 7575 mosquitoes collected Ghana were screened. prevalence observed at 1.8%. An. gambiae s.s constituted 87% positive while remaining coluzzii . Both sibling species had similar positivity rates (24% and 19%; p = 0.42) despite significantly higher number...
Although malaria and Anopheles mosquito vectors are highly prevalent in Côte d'Ivoire, limited data available to help understand the vector density transmission dynamics areas bordering country. To address this gap, species diversity, members of gambiae complex were assessed four health districts along borders d'Ivoire.From July 2016 through December 2017 2017, adult mosquitoes collected d'Ivoire (Aboisso, Bloléquin, Odienné Ouangolodougou) using standardized window exit trap (WET) pyrethrum...
Abstract The most widespread arboviral diseases such as Dengue, Chikungunya, and Zika are transmitted mainly by Aedes mosquitoes. Due to the lack of effective therapeutics for these diseases, vector control remains preventative measure. This study investigated compared species composition, insecticide susceptibility, resistance mechanisms in mosquito populations from a forest reserve converted an eco-park peri-domestic sites urban Accra, Ghana. Immature were sampled sites, raised adults,...
Abstract Monitoring vectors is relevant to ascertain transmission of lymphatic filariasis (LF). This may require the best sampling method that can capture high numbers specific species give indication transmission. Gravid anophelines are good indicators for assessing due close contact with humans through blood meals. study compared efficiency an Anopheles gravid trap (AGT) other mosquito collection methods including box and Centres Disease Control Prevention gravid, light, exit...
The Global Programme to Eliminate Lymphatic Filariasis (GPELF), launched in 2000, has the target of eliminating disease as a public health problem by year 2020. strategy adopted is mass drug administration (MDA) all eligible individuals endemic communities and implementation measures reduce morbidity those suffering from chronic disease. Success been recorded many rural which elimination efforts have centered. However, challenging several urban African cities. large cities West Africa,...
Background Lymphatic filariasis (LF) is widely endemic in Côte d'Ivoire, and elimination as public health problem (EPHP) based on annual mass drug administration (MDA) using ivermectin albendazole. To guide EPHP efforts, we evaluated Wuchereria bancrofti infection indices among humans, mosquito vectors after four rounds of MDA cross-border districts d'Ivoire. Methodology We monitored people mosquitoes for W. infections the Aboisso, Bloléquin, Odienné Ouangolodougou, circulating filarial...
Estimates of SARS-CoV-2 transmission rates have significant public health policy implications since they shed light on the severity illness in various groups and aid strategic deployment diagnostics, treatment vaccination. Population-based investigations not been conducted Ghana to identify seroprevalence SARS-CoV-2. We an age stratified nationally representative household study determine risk factors between February December 2021. Study participants, 5 years older regardless prior or...
Dengue, Zika and chikungunya are Aedes -borne viral diseases that have become great global health concerns in the past years. Several countries Africa reported outbreaks of these despite Ghana sharing borders with some countries, such yet to be detected. Viral RNA antibodies against dengue serotype-2 recently been among individuals localities regional capital Ghana. This is an indication a possible silent transmission ongoing population. study, therefore, investigated entomological risk...
Nose masks are widely worn for protection against respiratory pathogens, including SARS-CoV-2. They have been reported as possible substrates viral sampling and testing COVID-19 but, evaluations so far purposive; involving individuals known to the infection using improved materials on nose trap virus. We investigated feasibility of regular 3-ply surgical and, voluntary coughing a mode particle expulsion detecting SARS-CoV-2 infections in cross-sectional study at Ghana's first reference...
Mansonella perstans is a filarial parasite that causes mansonellosis in humans. Unlike other parasitic diseases, rarely symptomatic and hence poorly studied. This protocol describes the detection of M. blood. Firstly, DNA was extracted from dried blood blots (DBS). The were screened by nested PCR subsequently sanger sequencing done on excised gels. sequences then compared to reference deposited NCBI.
Mansonella spp . have been reported to a wide global distribution. Despite the distribution and co-occurrence with other filarial parasites like Wuchereria bancrofti , Onchocerca volvulus Loa loa it is given little attention. There are few surveillance programmes for assessing of mansonellosis, due associated mild no symptoms experienced by infected people. However, addressing this infection critical onchocerciasis control program as current rapid diagnostic tools targeting O tendency cross...
A significant proportion of SARS-CoV-2 infections in Africa are identified as asymptomatic, facilitating the silent spread virus especially populated urban cities. With surge highly transmissible Omicron variant, inclusion asymptomatics epidemiological surveys is key estimating true and seroprevalence population. The aim study was to determine seroprevalence, active infection circulating variants Accra, capital city Ghana during wave. a cross-sectional survey conducted 22 municipalities...
Abstract Effective control of helminth infections requires the application mathematical models to inform efforts and policy, development product profiles for new drugs, monitoring existing drugs resistance. Key success these approaches is accurately estimating number worms within a host, as well distinguishing, in drug efficacy trials monitoring, between adults surviving treatment who have reinfected host following treatment. In practice, observing adult often extremely challenging patient,...
Abstract Background : Microbiome dysbiosis is associated with various diseases, including COVID-19. The association of the oral microbiome SARS-CoV-2 infections and disease progression has been documented in European, Asian, American populations but not Africa. Methods We conducted a study Ghana to evaluate compare naso-oropharyngeal SARS-CoV-2-infected noninfected persons before after vaccination. 16S rDNA was sequenced analysed from DNA extracted swabs consenting participants. Results...
Abstract Mansonella spp . have been reported to a wide global distribution. Despite the distribution and occurrence with other filarial parasites like Wuchereria bancrofti, Onchocerca volvulus Lao loa , it is given little attention. Hence, there no surveillance programme for assessing or mansonellosis, mild symptoms experienced by infected people. However, addressing this infection critical onchocerciasis control program as current rapid diagnostic tools targeting O. tendency cross react...
Abstract Background Although malaria and Anopheles mosquito vectors are highly prevalent in Côte d'Ivoire, data still lacking on disease transmission dynamics cross-border areas. To address this lack of information, we assessed the vector species diversity, An. gambiae complex members four areas d'Ivoire. Method From July 2016 to December 2017, collected adult mosquitoes health districts d’Ivoire (Aboisso, Bloléquin, Odienné Ouangolodougou) using standardized window exit trap (WET) pyrethrum...
Abstract Background Malaria remains an important public health threat claiming many lives particularly in Sub-Saharan Africa. Light microscopy which is a blood-based test the Gold standard for laboratory diagnosis of malaria clinical settings. The lack sensitivity Microscopy coupled with challenges associated blood sampling necessitates exploring alternative methods identifying cases. Aims and Objectives aim this study was to detect presence Plasmodium Lactate Dehydrogenase (pLDH) falciparum...
Abstract Objective: Light microscopy which is a blood-based test the Gold standard for malaria diagnosis in clinical settings. The low sensitivity of Microscopy coupled with challenges associated blood sampling necessitates exploring alternative methods identifying cases. aim this study was to detect presence Plasmodium Lactate Dehydrogenase (pLDH) and falciparum Histidine-Rich Protein 2 (PfHRP2) saliva suspected patients compare diagnostic accuracy these saliva-borne biomarkers results film...