A5065377793- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Malaria Research and Control
- Influenza Virus Research Studies
- Hepatitis C virus research
- Respiratory viral infections research
- Zoonotic diseases and public health
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 detection and testing
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- Leptospirosis research and findings
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- COVID-19 diagnosis using AI
- Global Maternal and Child Health
- African Studies and Geopolitics
- Lung Cancer Diagnosis and Treatment
- Mathematical and Theoretical Epidemiology and Ecology Models
- COVID-19 Digital Contact Tracing
Noguchi Memorial Institute for Medical Research
2013-2024
University of Ghana
2013-2024
Ghana Health Service
2023
United States Naval Medical Research Unit SOUTH
2023
Navrongo Health Research Centre
2015-2022
University of Nebraska Medical Center
2022
United States Army Medical Research Institute of Infectious Diseases
2022
Institut de Recherche en Sciences de la Santé
2022
Centre Hospitalier Universitaire Yalgado Ouédraogo
2022
Kintampo Health Research Centre
2015-2018
Arthropod-borne viruses (arboviruses) are transmitted by arthropod vectors to humans, leading disease outbreaks mainly in tropical regions of the world.1Weaver SC Charlier C Vasilakis N Lecuit M Zika, chikungunya, and other emerging vector-borne viral diseases.Annu Rev Med. 2018; 69: 395-408Crossref PubMed Scopus (234) Google Scholar Although many arboviruses known, three Aedes-spp-borne particularly concerning for humans at a global scale due recurring large expanding epidemic dengue virus,...
Viral disease outbreak remains a key public health concern given its impact on life and livelihood. Historical data suggests Lassa fever is endemic in several West African countries with sporadic cases occurring elsewhere the region. In February 2023, Ghana recorded second of following that 2011. The present study sought to document epidemiology recent Ghana. used from case investigation forms accompanying samples submitted Noguchi Memorial Institute for Medical Research between March 2023...
In late 2019, a novel coronavirus, the SARS-CoV-2 outbreak was identified in Wuhan, China and later spread to every corner of globe. Whilst number infection-induced deaths Ghana, West Africa are minimal when compared with rest world, impact on local health service is still significant. Compartmental models useful framework for investigating transmission diseases societies. To understand how infection will limit outbreak. We have developed modified SEIR compartmental model nine compartments...
We report new molecular evidence of locally acquired dengue virus infections in Ghana. detected viral RNA among children with suspected malaria by using a multipathogen real-time PCR. Subsequent sequence analysis revealed close relationship serotype 2, which was implicated 2016 outbreak Burkina Faso.
Abstract Knowledge of contemporary genetic composition dengue virus (DENV) in Africa is lacking. By using next-generation sequencing samples from the 2017 DENV outbreak Burkina Faso, we isolated 29 genomes (5 serotype 1, 16 2 [DENV-2], and 8 3). Phylogenetic analysis demonstrated endemic nature DENV-2 Faso. We noted discordant diagnostic results, probably related to divergence between these Trioplex PCR. Forward reverse1 primers had a single mismatch when mapped genomes, explaining...
Blood samples of 218 children ages 2–14 years old with confirmed malaria in hospitals across Ghana were tested for dengue virus exposure. We detected dengue-specific immunoglobulin M (IgM) antibodies 3.2% the children, indicating possible coinfection, and IgG 21.6% them, which suggests previous Correlates exposure are discussed.
Background Viral hemorrhagic fevers (VHF) are acute diseases associated with bleeding, organ failure, and shock. VHF may hardly be distinguished clinically from other in the African hospital, including viral hepatitis. This study was conducted to determine if hepatitis contribute hospital morbidity Central Northern parts of Ghana. Methodology/Principal Findings From 2009 2011, blood samples 258 patients symptoms were collected at 18 hospitals Ashanti, Brong-Ahafo, Northern, Upper West, East...
Lassa fever is a potentially fatal acute viral illness caused by virus which carried rodents and endemic in some West African countries. Importation of emerging infections such as fever, Ebola Virus Disease other hemorrhagic fevers into non regions growing threat particularly international travel commitments resolving conflicts countries the Africa sub-region continue.We report first two recorded imported cases among Ghanaian Peace keepers rural Liberia, who became ill while on keeping...
Dengue fever is known to be one of the most common arthropod-borne viral infectious diseases public health importance. The disease now endemic in more than 100 countries Africa, Americas, Eastern Mediterranean, Southeast Asia and Western Pacific with an estimated two fifths world's population being at risk. notable hemorrhagic fevers (VHFs) found West including yellow fever, Lassa Rift Valley dengue until recently Ebola have been responsible for outbreaks fatal consequences. These VHFs...
Abstract Background Dengue virus (DENV) is a mosquito-borne arbovirus transmitted by Aedes mosquitoes, but not endemic in all areas where this vector found. For example, the relatively sparse distribution of cases West Africa generally attributed to refractory nature African aegypti ( Ae. ) DENV infection, and particularly forest-dwelling Ae . formosus However, recent studies have shown these mosquitoes be competent vectors within some countries that suffered outbreaks past, such as Senegal....
The global annual attack rate for influenza is estimated to be 10%-20% in children, although limited information exists Africa. In 2007, Ghana initiated surveillance by routine monitoring of acute respiratory illness obtain data on circulating strains. We describe children <11 years old who had influenza-like (ILI) from January 2008 December 2010.Oropharyngeal swabs pediatric outpatients with ILI attending any 22 health facilities across the country were submitted. tested virus using...
Arboviruses, Dengue and Chikungunya have become major international public health concerns due to their epidemics introduction in new areas. In Ghana, little is known about viruses though the country has been listed as part of 34 countries which are endemic. This attributed partly lack diagnostic tools for these several facilities institutions across country. The purpose this study was detect characterize viral pathogens among febrile patients Accra Ghana.This hospital-based cross-sectional...
Viral infections during pregnancy can pose serious threats to mother and fetus from the time of conception delivery. These lead congenital defects, spontaneous abortion even death. The definitive diagnosis management pregnancy-related viral may be challenging especially in less resourced countries. We present clinical laboratory responses three cases fulminant hepatitis secondary Hepatitis E infection pregnancy. Case 1 was a 31-year-old Ghanaian woman who presented with week's history...
In Ghana, Hepatitis B virus (HBV) infection remains a major public health threat as in many parts of the world. Even with an effective vaccine, there are shortfalls low vaccine coverage among adults. To create awareness and encourage vaccination, community engagement public-private partnerships needed endemic settings to help fund campaigns offer screening vaccinations at no cost under privileged people.An exercise was scheduled by University Ghana-based Hepatitis-Malaria (HEPMAL) project...
Hepatitis C virus (HCV) infection is a blood borne that remains potentially transmissible through transfusions. Sickle cell disease (SCD) common inheritable haemoglobinopathy in Ghana requires multiple transfusions as part of its management. The SCD patient therefore at high risk HCV infection; however, data on the occurrence patients has not been documented Ghana. This study sought to determine prevalence and genotypes patients.This was cross-sectional which enrolled 141 sickle-cell from...
Rodents serve as reservoirs and/or vectors for several human infections of high morbidity and mortality in the tropics. Population growth demographic shifts over years have increased contact with these mammals, thereby increasing opportunities disease transmission. In Africa, burden rodent-borne diseases is not well described. To investigate seroprevalence selected pathogens, sera from 657 healthy adults ten rural communities Ghana were analyzed. An in-house enzyme-linked immunosorbent assay...
Viral hemorrhagic fevers (VHFs) belong to a group of viral infectious diseases that interfere with the blood's clotting mechanism. VHF has wide host range, including bats, rodents, or arthropods such as mosquitoes and ticks. Most VHFs emerge suddenly outbreaks, making it difficult predict occurrence. To be responsive Noguchi Memorial Institute for Medical Research (NMIMR) provides high-end molecular genomic diagnostics capability surveillance suspected in samples collected from health...
Background Tuberculosis (TB) and COVID-19 pandemics are both diseases of public health threat globally. Both caused by pathogens that infect mainly the respiratory system, involved in airborne transmission; they also share some clinical signs symptoms. We, therefore, took advantage collected sputum samples at early stage outbreak Ghana to conduct differential diagnoses long-standing endemic illness, particularly tuberculosis. Methodology Sputum through enhanced national surveys from...
Abstract Background Influenza A viruses that cause highly pathogenic avian influenza (HPAI) also infect humans. In many developing countries such as Ghana, poultry and humans live in close proximity both the general military populations, increasing risk for spread of HPAI from birds to Respiratory infections are especially prone rapid among populations living quarters barracks making this a key population targeted surveillance public health education. Method Twelve situated coastal, tropical...
Background: Recent reports have shown an expansion of Lassa virus from the area where it was first isolated in Nigeria to other areas West Africa. Two Ghanaian soldiers on a United Nations peacekeeping mission Liberia were taken ill with viral haemorrhagic fever syndrome following death sick colleague and referred military hospital Accra, Ghana, May 2013. Blood samples five asymptomatic close contacts subjected laboratory investigations.Objective: We report results these investigations...
Complete and accurate information on disease occurrence is crucial for effective public health response to outbreaks. In the 2014 Ebola epidemic in West Africa, Ghana intensified surveillance across country. However, case definition provided by Ministry of Health was not uniformly applied at all reporting facilities.This paper analyses accompanying Case Record Forms (CRFs) submitted Noguchi Memorial Institute Medical Research determine its completeness appropriateness instituting an...