A5009109819- Malaria Research and Control
- Mosquito-borne diseases and control
- Hemoglobinopathies and Related Disorders
- Digital Imaging for Blood Diseases
- Blood groups and transfusion
- SARS-CoV-2 and COVID-19 Research
- Invertebrate Immune Response Mechanisms
- Imbalanced Data Classification Techniques
- Evolution and Genetic Dynamics
- Viral Infections and Vectors
- HIV Research and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Parasitic Diseases Research and Treatment
- Respiratory viral infections research
- Plant Virus Research Studies
- vaccines and immunoinformatics approaches
- Erythrocyte Function and Pathophysiology
- Viral Infections and Outbreaks Research
- Parasitic Infections and Diagnostics
- Trypanosoma species research and implications
- Travel-related health issues
- Insect Pest Control Strategies
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- Ophthalmology and Visual Health Research
University of Ghana
2018-2022
Kintampo Health Research Centre
2013-2022
Ghana Health Service
2013-2018
West End Hospital
2018
Tokyo Medical and Dental University
2018
University of Virginia
2018
Centers for Disease Control and Prevention
2018
Abstract The COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 genomes from patient isolates (121 arriving travellers and 1002 communities) track molecular spatio-temporal dynamics variants Ghana. data show that initial local transmission was dominated by B.1.1 lineage, but second wave overwhelmingly driven Alpha variant. Subsequently, an unheralded variant under...
We report new molecular evidence of locally acquired dengue virus infections in Ghana. detected viral RNA among children with suspected malaria by using a multipathogen real-time PCR. Subsequent sequence analysis revealed close relationship serotype 2, which was implicated 2016 outbreak Burkina Faso.
Background. Whether the risk of malaria is increased in infants born to mothers who experience during pregnancy uncertain. Methods. We investigated incidence among an infant cohort 355 primigravidae and 1500 multigravidae with or without placental (PM) a high transmission area Ghana. PM was assessed using histology. Results. The all episodes parasitemia clinical very similar 3 groups infants: those PM, PM. Infants experienced lower than other groups: adjusted hazard ratio, 0.64 (95%...
Genome wide sequence analyses of malaria parasites from widely separated areas the world have identified contrasting population structures and signatures selection. To compare relatively closely situated but ecologically regions within an endemic African country, samples Plasmodium falciparum clinical isolates were collected in Ghana Kintampo central forest-savannah area, Navrongo a drier savannah area ~350 km to north with more seasonally-restricted transmission. Parasite DNA was sequenced...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most widespread enzyme defect that can result in red cell breakdown under oxidative stress when exposed to certain medicines including antimalarials. We evaluated diagnostic accuracy of CareStart G6PD Rapid Diagnostic Test (RDT) as a point-of-care tool for screening deficiency.A cross-sectional study was conducted among 206 randomly selected and consented participants from group with known status between February 2013 June 2013. A...
Plasmodium falciparum invades human erythrocytes by using an array of ligands that interact with several receptors, including sialic acid (SA), complement receptor 1 (CR1), and basigin. We hypothesized in malaria-endemic areas, parasites vary invasion pathways under immune pressure. Therefore, mechanisms clinical isolates collected from 3 zones Ghana different levels endemicity (from lowest to highest, Accra, Navrongo, Kintampo) were compared standardized methods.Blood samples children aged...
Abstract Background Malaria is still a major global health burden, with more than 3.2 billion people in 91 countries remaining at risk of the disease. Accurately distinguishing malaria from other diseases, especially uncomplicated (UM) non-malarial infections (nMI), remains challenge. Furthermore, success rapid diagnostic tests (RDTs) threatened by Pfhrp2/3 deletions and decreased sensitivity low parasitaemia. Analysis haematological indices can be used to support identification possible...
Background Red blood cell (RBC) polymorphisms are common in malaria endemic regions and known to protect against severe forms of the disease. Therefore, it is important screen for these drugs or vaccines efficacy trials. This study was undertaken evaluate associations between clinical RBC assess biological interactions that may be necessary consideration when designing Method In a cross-sectional 341 febrile children less than five years age, including sickle gene G6PD deficiency evaluated...
Background Rapid diagnostic test (RDT) kits have been useful tools to screen for the presence of infection with malaria parasites. Despite improvement, false results from RDTs present a greater challenge. The need quality is desirable. We evaluated accuracy three RDTs. Method team consented and enrolled 754 participants two major public hospitals in Kintampo districts Ghana June 2014 August 2014. Venous blood samples were obtained by trained personnel screened using CareStart SD Bioline HRP2...
Background: An insecticide susceptibility study was carried out on Anopheles gambiae sensu lato vectors in 11 districts Ghana between October 2012 and January 2013. Methods:An. s.l. larvae were collected, bred under standard conditions, 3–5 d postemerged females used for bioassay. Between 22 25 female An. fed only 10% sugar testing. Exposure 1 h (2 fenitrothion). . that knocked down recorded every 10 min mortalities 24 posttest. Eleven insecticides from four chemical classes used:...
Abstract Background Malaria is still a major global health burden, with more than 3.2 billion people in 91 countries remaining at risk of the disease. Accurately distinguishing malaria from other diseases, especially uncomplicated (UM) non-malarial infections (nMI) remains challenge. Furthermore, success rapid diagnostic tests (RDT) threatened by Pfhrp2/3 deletions and decreased sensitivity low parasitemia. Analysis haematological indices can be used to support identification possible cases...
Glycophorins are the most abundant sialoglycoproteins on surface of human erythrocyte membranes. Genetic variation in glycophorin region chromosome 4 (containing GYPA, GYPB, and GYPE genes) is interest because gene products serve as receptors for pathogens major public health interest, including Plasmodium sp., Babesia Influenza virus, Vibrio cholerae El Tor Hemolysin, Escherichia coli. A large structural rearrangement hybrid variant, known Dantu, which was identified East African...
Abstract This study sequenced 1077 SARS-CoV-2 genomes from patient isolates (106 arriving travellers and 971 communities) to track the molecular evolution spatio-temporal dynamics of variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineages, but second wave Ghana overwhelmingly driven Alpha variant, which detected community cases January 2021, with Eta also contributing reported cases. Subsequently, an unheralded variant under monitoring, B.1.1.318,...
To examine the association between animal contact (primarily dogs and cats) non-malarial fever, as well with secondary symptoms of headache, nausea, vomiting, cough, in 687 children Greater Accra Region, Ghana.Cross-sectional study acute febrile illness among aged 1-15 years old October 2016 August 2017.Ledzokuku-Krowor Municipal Assembly (LEKMA) Hospital, Teshie, Region.The included defined a measured temperature greater than 37.5°C, occurring less seven days before hospital visit, afebrile...