A5005494141- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Malaria Research and Control
- Viral Infections and Vectors
- Insect Utilization and Effects
- Insect and Pesticide Research
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- Parasitic Infections and Diagnostics
Noguchi Memorial Institute for Medical Research
2020-2025
University of Ghana
2020-2024
University of Glasgow
2022
<title>Abstract</title> Background Malaria remains a significant public health challenge, necessitating innovative strategies to break transmission, such as interrupting successful <italic>Plasmodium falciparum</italic> development in the vector using microbiota. While this transmission-blocking has been demonstrated experimentally low ookinete or oocyst intensity mosquito, little is known about effect of these microbes on gametocytes, which are first stages parasite that mosquito host...
Abstract A vertically transmitted microsporidian, Microsporidia MB , with the ability to disrupt Plasmodium development was reported in Anopheles arabiensis from Kenya, East Africa. To demonstrate its range of incidence, archived DNA samples 7575 mosquitoes collected Ghana were screened. prevalence observed at 1.8%. An. gambiae s.s constituted 87% positive while remaining coluzzii . Both sibling species had similar positivity rates (24% and 19%; p = 0.42) despite significantly higher number...
Some bacteria species found in the mosquito midgut have demonstrated their role interrupting development of Plasmodium within Anopheles and been identified as potential candidates for novel bacteria-mediated disease control. However, to use these successfully biocontrol mechanisms effect on fitness vector into which they introduced has be evaluated. This study investigated two such candidates, Enterobacter cloacae Serratia marcescens, gambiae s.l. fitness. Pupae larvae mosquitoes were...
Abstract The most widespread arboviral diseases such as Dengue, Chikungunya, and Zika are transmitted mainly by Aedes mosquitoes. Due to the lack of effective therapeutics for these diseases, vector control remains preventative measure. This study investigated compared species composition, insecticide susceptibility, resistance mechanisms in mosquito populations from a forest reserve converted an eco-park peri-domestic sites urban Accra, Ghana. Immature were sampled sites, raised adults,...
Dengue, Zika and chikungunya are Aedes -borne viral diseases that have become great global health concerns in the past years. Several countries Africa reported outbreaks of these despite Ghana sharing borders with some countries, such yet to be detected. Viral RNA antibodies against dengue serotype-2 recently been among individuals localities regional capital Ghana. This is an indication a possible silent transmission ongoing population. study, therefore, investigated entomological risk...
Novel ideas for control of mosquito-borne disease include the use bacterial symbionts to reduce transmission. Bacteria belonging family Enterobacteriaceae isolated from mosquito midgut have shown promise in limiting Plasmodium intensity Anopheles vector. However, mechanism interaction between bacteria and parasite remains unclear. This study aimed at screening bio-products two candidates their anti-Plasmodial effects on stages P. falciparum. Enterobacter cloacae Serratia marcescens were...
<title>Abstract</title> The fungus, <italic>Microsporidia MB</italic> disrupts <italic>Plasmodium</italic> development in <italic>Anopheles</italic> mosquitoes. It has been associated with <italic>An. gambiae</italic> and coluzzii</italic> (Ghana), arabiensis</italic> (Kenya) from rice fields. As a tool for vector/disease control, its ecological distribution factors that determine their occurrence must be defined. We investigated the prevalence of mosquitoes across selected sites Ghana,...
Abstract Background Microsporidia MB disrupts Plasmodium development in Anopheles mosquitoes, making it a possible biocontrol tool for malaria. As vector/disease control, its ecological distribution and the factors that determine their occurrence must be defined. We investigated frequency of mosquitoes across selected sites northern southern Ghana, as well physicochemical parameters mosquito breeding water are associated with fungus, by fitting regression models. Methods A non-column...
Abstract A vertically transmitted microsporidian, Microsporidia MB, with the ability to disrupt Plasmodium development was reported in Anopheles arabiensis from Kenya, East Africa. To demonstrate its range of incidence, archived DNA samples 7575 mosquitoes collected Ghana were screened. MB prevalence observed at 1.8%. An. gambiae s.s constituted 87% positive while remaining coluzzii. Both sibling species had similar positivity rates (24% and 19%; p= 0.42) despite significantly higher number...
Abstract Background Dengue, Zika and Chikungunya are Aedes-borne viral diseases that have risen to become great global health concerns in the past years. Several countries Africa reported outbreaks of these despite Ghana sharing borders with some such countries, it remains free outbreaks. Recent studies revealed there antibodies RNA Dengue virus serotype-2 among individuals localities Greater Accra Region. This is an indication a possible silent transmission ongoing population, hence need...