A5078896700- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Viral Infections and Vectors
- Phytochemical compounds biological activities
- Vector-Borne Animal Diseases
- Pharmacological Effects of Natural Compounds
- Morinda citrifolia extract uses
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Infections and bacterial resistance
- Insect and Pesticide Research
- Malaria Research and Control
- Synthesis and biological activity
- Antibiotic Resistance in Bacteria
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Plant Pathogenic Bacteria Studies
- Bacterial biofilms and quorum sensing
- Insect symbiosis and bacterial influences
- Genetics, Bioinformatics, and Biomedical Research
- Microbial Natural Products and Biosynthesis
- Drug Transport and Resistance Mechanisms
Tokyo Medical and Dental University
2017-2021
Noguchi Memorial Institute for Medical Research
2016-2021
University of Ghana
2016-2021
Trypanosomiasis, leishmaniasis, and malaria are protozoan infections of public health importance with thousands new cases recorded annually. Control these infection(s) existing chemotherapy is limited by drug toxicity, lengthy parenteral treatment, affordability, and/or the emergence resistant strains. Medicinal plants on other hand used in treatment various infectious diseases although their chemical properties not fully evaluated. In this study, we screened 112 crude extracts from 72...
Entomological surveillance is one of the tools used in monitoring and controlling vector-borne diseases. However, use entomological for arboviral infection vector control often dependent on finding infected individuals. Although this method may suffice highly endemic areas, it not as effective spread diseases low non-endemic areas. In study, we examined efficiency using markers to assess status risk arbovirus Ghana, which considered a country, by combining mosquito with virus isolation...
A new alkaloid paenidigyamycin (1) was obtained from the novel Ghanaian Paenibacillus sp. isolated mangrove rhizosphere soils of Pterocarpus santalinoides tree growing in wetlands Digya National Park, Ghana. Compound 1 on HPLC at tR = 37.0 min and its structure determined by MS, 1D, 2D-NMR data. When tested against L. major, (IC50 0.75 µM) just as effective amphotericin B 0.31 µM). Against donovani, 7.02 twenty-two times less active than 0.32 µM), reinforcing unique effectiveness major. For...
Abstract Background Dengue virus (DENV) is a mosquito-borne arbovirus transmitted by Aedes mosquitoes, but not endemic in all areas where this vector found. For example, the relatively sparse distribution of cases West Africa generally attributed to refractory nature African aegypti ( Ae. ) DENV infection, and particularly forest-dwelling Ae . formosus However, recent studies have shown these mosquitoes be competent vectors within some countries that suffered outbreaks past, such as Senegal....
Global dissemination of New Delhi metallo-β-lactamase (NDM)-producing bacteria has become a major health threat. However, there are few reports regarding the identification and characterisation NDM-producing from West Africa, including Ghana. An Escherichia coli strain with resistance to meropenem was isolated Tamale Teaching Hospital in Its determination antibiotic susceptibility profile were carried out using commercial systems. The mechanism analysed by phenotypic detection kits, PCR, DNA...
Leishmaniasis is an infectious disease transmitted by the sand fly. It caused over 20 different species of Leishmania and has affected 14 million people worldwide. One main forms control leishmaniasis chemotherapy, but this limited high cost and/or toxicity available drugs. We previously found three novel compounds with iridoid tetracyclic skeleton to have activity against trypanosome parasites. In study, we determined anti-trypanosome using field strain, 010, lab strain hertigi. The minimum...
African trypanosomiasis is a disease caused by the parasitic protozoa of
In the absence of vaccines, there is a need for alternative sources effective chemotherapy African trypanosomiasis (AT). The increasing rate resistance and toxicity commercially available antitrypanosomal drugs also necessitates an investigation into mode action new antitrypanosomals AT. this study, furoquinoline 4, 7, 8-trimethoxyfuro (2, 3-b) quinoline (compound 1) oxylipin 9-oxo-10, 12-octadecadienoic acid 2) were isolated from plant species Zanthoxylum zanthoxyloides (Lam) Zepern Timler...
The plant Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler is one of the most important medicinal species genus on African continent. It used in treatment and management parasitic diseases sub-Saharan Africa. These properties have inspired scientists to investigate within for bioactive compounds. However, a study, which details spectroscopic, spectrometric bioactivity guided extraction isolation antiparasitic compounds from currently non-existent. Tortozanthoxylamide (1), derivative...
Visceral leishmaniasis (VL) is a major problem worldwide and causes significant morbidity mortality. Existing drugs against VL have limitations, including their invasive means of administration long duration treatment regimens. There are also concerns regarding increasing relapses as well the identification resistant clinical strains with use miltefosine, sole oral drug for VL. is, therefore, an urgent need new alternative In present study, we show leishmanicidal effect novel, antimalarial...
The compounds quinolactacin A2 (2) and citrinadin A (13) which are originally considered to be the of fungi genus Penicillium, were co-isolated for first time from new fungal strain Cladosporium oxysporum BRS2A-AR2F (Genebank number KX257257) is an endophyte Ghanaian mangrove plant Rhizophora racemosa.A derivative A, was named butrecitrinadin (12) also isolated fermentation cultures this strain.The structures (2), determined using a combination mass spectrometry with 1D 2D NMR data...
African trypanosomiasis poses serious health and economic concerns to humans livestock in several sub-Saharan countries. The aim of the present study was identify antitrypanosomal compounds from