A5043922496- Ethnobotanical and Medicinal Plants Studies
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Mycobacterium research and diagnosis
- Morinda citrifolia extract uses
- Phytochemistry and Biological Activities
- Malaria Research and Control
- Phytochemistry and Bioactivity Studies
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activities of Ficus species
- Synthesis and Characterization of Heterocyclic Compounds
- Research on Leishmaniasis Studies
- Traditional and Medicinal Uses of Annonaceae
- Moringa oleifera research and applications
- Genomics, phytochemicals, and oxidative stress
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Heavy metals in environment
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
Noguchi Memorial Institute for Medical Research
2015-2024
University of Ghana
2015-2024
37 Military Hospital
2022
ORCID
2021
Society of Environmental Toxicology and Chemistry
2009
Vrije Universiteit Amsterdam
2007-2009
Aims: The current study was designed to document medicinal plant species that are traditionally used treat tuberculosis (TB) by Ghanaian communities.Methods: plants against TB or its signs and symptoms were selected using library online published data searches. A guided questionnaire interview also conducted with a botanist involved in collection at the Centre for Scientific Research into Plant Medicine (CSRPM) Mampong. Data obtained entered Excel summarized means frequencies SPSS 12.0.1...
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains an ongoing threat to human health. Several medicinal plants are used traditionally treat in Ghana. The current study was designed investigate the antimycobacterial activity and cytotoxicity of crude extracts from five selected plants.The microplate alamar blue assay (MABA) for studies while CellTiter 96® AQueous Assay, which is composed solutions a novel tetrazolium compound...
Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on single drug, praziquantel, motivation for the search of novel antischistosomal compounds. This study investigated anthelmintic activity stem bark and roots Rauwolfia vomitoria against two life stages Schistosoma mansoni . Both plant parts were found to active cercariae adult worms. Within 2 h exposure all killed at concentration range 62.5–1000 µ g/mL 250–1000 R. roots,...
Trypanosomiasis, leishmaniasis, and malaria are protozoan infections of public health importance with thousands new cases recorded annually. Control these infection(s) existing chemotherapy is limited by drug toxicity, lengthy parenteral treatment, affordability, and/or the emergence resistant strains. Medicinal plants on other hand used in treatment various infectious diseases although their chemical properties not fully evaluated. In this study, we screened 112 crude extracts from 72...
Abstract The concentration of seven heavy metals in water samples was analyzed along the southwest coast Ghana wet and dry seasons using atomic absorption spectrophotometer. Some physicochemical properties were also determined to assess quality water. ranges metal season were; As (1.23–7.84 µg/L), Cu (4.10–24.09 Pb (4.08–57.98 Se (BDL-0.38 Zn (2.86–17.75 µg/L) Hg (0.023–0.068 whereas (2.30–5.78 (25.47–70.73 (0.081–0.158 (0.79–22.80 (0.004–0.047 µg/L). results pH (6.83 7.52), EC...
Purpose: This study presents a novel and sustainable approach to cancer therapy by combining halloysite nanotubes (HNTs), green‐synthesized copper oxide (CuO) nanoparticles, curcumin (CUR). We demonstrate that the green synthesis of CuO when combined with CUR incorporated into HNTs, enhances delivery anticancer effects CUR. innovative complex could address some critical limitations current therapies such as poor pharmacokinetics drug resistance providing controlled release mechanism...
Trypanosoma brucei parasites are kinetoplastid protozoa that devastate the health and economic well-being of millions people in Africa through disease human African trypanosomiasis (HAT). New chemotherapy has been eagerly awaited due to severe side effects drug resistance issues plaguing current drugs. Recently, there an emphasis on use medicinal plants worldwide. Morinda lucida Benth. is a popular plant widely distributed Africa, several research groups have reported antiprotozoal...
Nymphaea lotus L. (N. lotus) is an aquatic plant with anecdotal reports suggesting its use in the traditional management of cancer. However, there a paucity data on antioxidant, anti-inflammatory and cytotoxic properties N. relation to phytochemical elemental contents. This study aimed at determining hydro-ethanolic extract leaves (NLE), phenolic, flavonoid constituents.The antioxidant property NLE was determined using total phenolic flavonoid, DPPH radical scavenging, lipid peroxidation...
Now that highly active antiretroviral therapy (HAART) is being initiated on a large scale in West Africa, it remains controversial whether protease inhibitors (PIs), originally designed and tested against human immunodeficiency virus type 1 (HIV-1) subtype B, are equally effective the non-B subtypes prevalent African countries. In this study, we investigated Ghanaian HIV-1 isolates, as representatives of susceptible to PIs.We first generated an cassette vector proviral DNA carrying...
Glutathione S-transferases (GSTs) are important phase II drug-metabolizing enzymes that play a major role in protecting cells from the toxic insults of electrophilic compounds. Curcumin, promising chemotherapeutic agent, inhibits human GSTA1-1, GSTM1-1, and GSTP1-1 isoenzymes.In present study, effect three series curcumin analogues, 2,6-dibenzylidenecyclohexanone (A series), 2,5-dibenzylidenecyclopentanone (B 1,4-pentadiene-3-one (C series) substituted analogues (n = 34), on these GST...
Malaria is one of the most important life-threatening infectious diseases in tropics. In spite effectiveness artemisinin-based combination therapy, reports on reduced sensitivity parasite to artemisinin Cambodia and Thailand warrants screening for new potential antimalarial drugs future use. Ghanaian herbalists claim that Polyalthia longifolia has activity. Therefore, antiplasmodial activity, cytotoxic effects, antioxidant phytochemical properties P. leaf extract were investigated this...
Most developing countries resort to medicinal plants for treating diseases, but few of these have scientific backing their use. The aim the study was validate traditional use Morinda lucida leaves in inflammation and determine mechanism action.Effect hydroethanolic leaf extract M. (HEML) on localized evaluated using rat paw edema presented by sub-planter injections λ-carrageenan, histamine or serotonin separate experiments. Systemic lipopolysaccharide (LPS)-induced hyperthermia. Antioxidant...
COVID-19 is a disease that caused by pathogen known as coronavirus 2 (SARS-CoV-2). Coronaviruses belong to superfamily of viruses which infect both humans and animals. These are positive-stranded RNA enveloped replicate in the cytoplasm. Their envelope fuses with host cell membrane then nucleocapsid delivered into host. Spike glycoproteins mediate virus entry necessary stage for tropism well pathogenesis.
A tetrazolium-based colorimetric selective assay (MTT-based CSA) was developed to assess the selectivity of antimalarial drugs. This in vitro assay, unlike all others, measures ability drugs indirectly protect red blood cells (RBCs) from Plasmodium-falciparum-induced destruction. Optimum incubation time and number needed were 5 days 23 × 10(6) RBCs per well, respectively. parasitemia range 0.375% 3% found be suitable for this assay. The MTT-based CSA determined anti-P. falciparum strain DD2...