A5028983415- Natural Antidiabetic Agents Studies
- Ethnobotanical and Medicinal Plants Studies
- African Botany and Ecology Studies
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Pharmacology and Obesity Treatment
- Traditional and Medicinal Uses of Annonaceae
- Food Chemistry and Fat Analysis
- Malaria Research and Control
- Morinda citrifolia extract uses
- Complementary and Alternative Medicine Studies
- Diverse Scientific Research Studies
- Phytochemistry Medicinal Plant Applications
- Advances in Cucurbitaceae Research
- Hydrogels: synthesis, properties, applications
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Medicinal Plants
- Animal Nutrition and Physiology
- Pain Mechanisms and Treatments
- Lichen and fungal ecology
- Bioactive natural compounds
- Antioxidant Activity and Oxidative Stress
- Phytochemistry and Bioactive Compounds
- Biocrusts and Microbial Ecology
- Phytochemistry and biological activity of medicinal plants
University of Ghana
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Kwame Nkrumah University of Science and Technology
2013
Nymphaea lotus L. (N. lotus) is an aquatic plant with anecdotal reports suggesting its use in the traditional management of cancer. However, there a paucity data on antioxidant, anti-inflammatory and cytotoxic properties N. relation to phytochemical elemental contents. This study aimed at determining hydro-ethanolic extract leaves (NLE), phenolic, flavonoid constituents.The antioxidant property NLE was determined using total phenolic flavonoid, DPPH radical scavenging, lipid peroxidation...
Obesity and overweight are metabolic disorders associated with oxidative stress, risk factors for many chronic diseases. We sought to investigate the effects of Metaswitch dietary supplement on weight gain acute alterations in a high-fat diet-induced rat model.Female Sprague Dawley (SD) rats were put into 6 groups. Control groups fed normal (NCD) or diet (HFD). Treatment HFD receieved 3 different daily doses weeks. Another group received Slimrite® (phenylpropanolamine), standard drug. Rats...
Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract whole plant has demonstrated antinociceptive effect various animal models This study investigated potential benefit a rat model paclitaxel-induced neuropathic Neuropathy was induced rats continuous intraperitoneal administration paclitaxel (2 mg/kg) 5 days. Baseline latencies to thermal pain were recorded before first injection during day induction period....
Hypertension is a highly prevalent public health problem among Africans, including Ghanaians, and it major risk factor for cardiovascular diseases such as congestive heart failure, kidney disease, coronary artery disease.Hypertension occurs at rate of 19% to 48% across Ghana; because about 70% the patients are believed be using herbs manage this condition, important know kind plants that used in management condition.The aim study was therefore conduct an ethnomedicinal survey document...
In Ghana, majority of the people patronize herbal medicines for treatment both chronic and acute ailments as well infectious non-infectious diseases.As such, use herbs in enteric (typhoid) fever is very widespread.Aims: This study therefore investigates anti-typhoidal medicinal formulations that are sale on Ghanaian market with regards to contents product labels assesses various active plant components light documented evidence their typhoid.
We developed and validated a new analytical method for the simultaneous quantification of artemether lumefantrine in fixed-dose tablets powders reconstitution into pediatric suspensions (PSs). The showed linearity (r(2) > 0.9947), precision (coefficient variation < 2%), accuracy (deviation mean from actual concentrations 4%), specificity (peak purities 99%). was used to analyze 24 batches PSs lumefantrine. Of samples, 23 were obtained using convenience sampling commonly available brands...
Background: Borassus aethiopum Mart (Family Arecaceae), commonly known as the African Fan Palm, is a tropical plant species found widely across Africa, and used globally for both medicinal non-medicinal purposes. In this study, anti-oxidant, anti-microbial anti-inflammatory activities of an ethanolic extract fruit was investigated. Methods: The Carrageenan induced foot edema model in chicks to investigate activity seed endocarp cotyledon. For anti-oxidant determination, three assays were...
Some local communities in Cote d'Ivoire use the mushroom Termitomyces schimperi combined with kaolin (TSK) to manage various cancers patients. However, there is a paucity of data on toxicity, mutagenicity and trace metal constituent TSK. We sought investigate acute sub-chronic toxicities, mutagenic potential, constituents To assess single doses (1000, 3000 5000 mg/kg) aqueous extract TSK were administrated per os Sprague Dawley (SD) rats Day 1. The then monitored for 13 consecutive days....
Unsweetened natural cocoa has antimalarial properties. powder (UNCP), obtained as a result of the removal butter from bean protects against malaria episodes. Cocoa powder, which is prepared after butter, contains about 1.9 % theobromine and 0.21 caffeine. Concomitant consumption artemether/lumefantrine (A/L) common practice in Ghana, West Africa. This study seeks to determine elemental composition UNCP its protective effect on heart kidney administration.Energy dispersive x-ray fluorescence...
Introduction: This work was conducted in order to investigate the hypoglycaemic and antioxidant activity of stem bark Morinda lucida Benth (Rubiaceae), which has traditionally been used Ghana for management diabetes mellitus. Methods: The powdered successively Soxhlet-extracted with petroleum ether 70% v / ethanol, respectively, were then evaporated dryness produce crude (PML) ethanolic (EML) extracts. PML EML determined streptozotocin-induced diabetic rats. Five groups six rats received...
The leaves of Pergularia daemia Forsk (family Asclepidaceae) provide alternative plant-based treatments for the management diabetes mellitus and diarrhoea in both humans indigenous poultry species like Guinea fowls (Numida meleagris). However, no scientific investigations to validate its usefulness Ghana have been established. This study therefore sought investigate anti-hyperglycaemic activity 70 % ethanolic extract P. using streptozotocin (STZ)-induced diabetic male Sprague-Dawley rats....
Unsweetened natural cocoa powder (UNCP), prepared after removal of the butter, is a common beverage in Ghana. It possesses antimalarial prophylactic property and has beneficial effect on blood components.The aim this study was to determine whether regular dietary supplement UNCP mitigates high-dose (HD) artemether-lumefantrine (A-L)-induced hematological disorders nitric oxide (NO) levels.Adult male guinea pigs (300 g - 350 g) were randomly divided into 5 groups 6 each. Among groups, 3...
Abstract Background Diabetes Mellitus (DM) is a major health problem, with global prevalence of 9.3%, 4.7% in Africa, and 2.5% Ghana. Despite the availability classic anti-diabetic medications, many patients have not benefited from them due to their poor glycemic controls, high costs, inability halt disease progression, untoward side effects. Some thus resort plant-based medicines such as those obtained L. taraxacifolia etc., which little empirical evidence efficacy. Therefore, this study...
Adansonia digitata L. is a tree indigenous to Ghana and West Africa. It traditionally used for medicinal, religious nutritional purposes. Different parts of the plant are treatment diseases such as anaemia, malaria, asthma diarrhoea among others. therefore necessary provide standard parameters identification purpose quality control. This study thus sought investigate pharmacognostic characteristics elemental properties leaves stem bark A. grown in Ghana. The macroscopic microscopic...
Herbal medicinal products play a significant role in the management of diabetes and other chronic diseases either as monotherapy or combination with allopathic treatments. The hypoglycemic activity Ghanaian herbal antidiabetic product (Bridelia Tea) prepared from dried leaves Bridelia ferrugenia [BRD] was reevaluated this study view improving, its explore possible benefit using metformin (MET). Male female Sprague-Dawley rats (210-220 g) were rendered hyperglycemic by single intraperitoneal...
Aims: This work aims to investigate the phytochemical composition and antioxidant potential of leaves Macaranga heterophylla. Methodology: For this purpose, screening by detection tests thin layer chromatography (TLC), determination total phenols content, flavonoids content condensed tannins assessment DPPH reducing power were carried out on aqueous crude extracts, ethanolic extracts selective M. Results: The percentage yields obtained with ethanol (70%) (28.90 24.70% for decoction macerate...
Information available on the various forms of Complementary and Alternative Medicine (CAM) used in management hypertension is inadequate conflicting. The primary objective this study was to assess use CAM by practition-ers. A qualitative utilizing semi-structured interview guides elicited responses prac-tices from practitioners who were involved management. All interviews audio recorded manually transcribed. final text processed content thematically analyzed. Out thirteen interviewed, there...
Millingtonia hortensis Linn. (Bignoniaceae) is a medicinal plant used for the treatment of various diseases such as fever, asthma, and microbial infections. This study aimed to investigate quality control parameters leaf stem bark proper authentication prevent adulteration. The macroscopic microscopic characteristics, phytochemical, physicochemical, fluorescence properties, heavy metal content M. w