A5076522576- Heavy metals in environment
- Seaweed-derived Bioactive Compounds
- Geochemistry and Geologic Mapping
- Traditional and Medicinal Uses of Annonaceae
- Mycotoxins in Agriculture and Food
- Selenium in Biological Systems
- Malaria Research and Control
- Drug-Induced Hepatotoxicity and Protection
- Fatty Acid Research and Health
- Click Chemistry and Applications
- Pharmacological Effects of Natural Compounds
- Biosensors and Analytical Detection
- Therapeutic Uses of Natural Elements
- Lichen and fungal ecology
- Heavy Metals in Plants
- Insect Pest Control Strategies
- Nanocomposite Films for Food Packaging
- Municipal Solid Waste Management
- HIV/AIDS drug development and treatment
- Advanced Drug Delivery Systems
- Genetics, Bioinformatics, and Biomedical Research
- Wheat and Barley Genetics and Pathology
- Moringa oleifera research and applications
- Bioactive natural compounds
- Natural Compound Pharmacology Studies
Noguchi Memorial Institute for Medical Research
2020-2024
University of Ghana
2016-2024
Sojo University
2024
ORCID
2021
Abstract The concentration of seven heavy metals in water samples was analyzed along the southwest coast Ghana wet and dry seasons using atomic absorption spectrophotometer. Some physicochemical properties were also determined to assess quality water. ranges metal season were; As (1.23–7.84 µg/L), Cu (4.10–24.09 Pb (4.08–57.98 Se (BDL-0.38 Zn (2.86–17.75 µg/L) Hg (0.023–0.068 whereas (2.30–5.78 (25.47–70.73 (0.081–0.158 (0.79–22.80 (0.004–0.047 µg/L). results pH (6.83 7.52), EC...
Purpose: This study presents a novel and sustainable approach to cancer therapy by combining halloysite nanotubes (HNTs), green‐synthesized copper oxide (CuO) nanoparticles, curcumin (CUR). We demonstrate that the green synthesis of CuO when combined with CUR incorporated into HNTs, enhances delivery anticancer effects CUR. innovative complex could address some critical limitations current therapies such as poor pharmacokinetics drug resistance providing controlled release mechanism...
Most developing countries resort to medicinal plants for treating diseases, but few of these have scientific backing their use. The aim the study was validate traditional use Morinda lucida leaves in inflammation and determine mechanism action.Effect hydroethanolic leaf extract M. (HEML) on localized evaluated using rat paw edema presented by sub-planter injections λ-carrageenan, histamine or serotonin separate experiments. Systemic lipopolysaccharide (LPS)-induced hyperthermia. Antioxidant...
<title>Abstract</title> Background The global call for malaria eradication rested on finding drugs that not only act against asexual but also sexual forms of the parasite. drawbacks in disease control and prevention due to drug-resistant clones parasite piqued our interest exploring alternative antimalarial from mangrove resources. Aims This study evaluates stage-specific anti-malarial cytotoxic activities fractions crude alkaloidal extracts <italic>Avicennia africana</italic> leaves....
While metal exposures are generally high among informal electronic waste (e-waste) recyclers, the joint effect of metals and dietary macronutrients on their metabolic health is unknown. Therefore, we investigated relationship between exposures, intake, blood glucose levels e-waste recyclers at Agbogbloshie using information (48-h recall survey), (Pb & Cd), HbA1C 151 participants (100 51 controls from Accra, Ghana) in March 2017. A linear regression model was used to estimate macronutrient...
Some local communities in Cote d'Ivoire use the mushroom Termitomyces schimperi combined with kaolin (TSK) to manage various cancers patients. However, there is a paucity of data on toxicity, mutagenicity and trace metal constituent TSK. We sought investigate acute sub-chronic toxicities, mutagenic potential, constituents To assess single doses (1000, 3000 5000 mg/kg) aqueous extract TSK were administrated per os Sprague Dawley (SD) rats Day 1. The then monitored for 13 consecutive days....
The challenges concerning the control of malaria remain due to continuous emergence drug resistant strains. Over years, use, misuse, and abuse antimalarials have created a conducive environment for development Plasmodium falciparum We herein report on synthesis, characterization antimalarial activity library seven novel 1,2,3-triazoles as part discovery campaign against drug-resistant falciparum. interactions triazoles with plasmepsin II, IV, falcipain-2 heme detoxifying protein-all key...
Objective: Nitric oxide (NO) is a signaling molecule that plays key role in the pathogenesis of inflammation. Inhibitors NO may be useful candidates for treatment inflammatory diseases. The study aimed to determine antioxidant and inhibitory effect commonly used Ghanaian vegetables, namely Corchorus olitorius (CO), Solanum melongena (SM), torvum (ST), Xanthosoma sagittifolia (XS) Abelmoschus esculentus (AE) on expression Lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cell line....
Background. The emergence of drug-resistant parasites impedes disease management and eradication efforts. Hence, a reinvigorated attempt to search for potent lead compounds in the mangroves is imperative. Aim. This study evaluates vitro antiplasmodial activity, antioxidant properties, cytotoxicity A. africana leaf alkaloidal extracts. Methods. leaves were macerated with 70% ethanol obtain total crude extract. Dichloromethane chloroform-isopropanol (3 : 1, v/v) used extract alkaloids...
Drug interactions are key reasons for adverse drug reactions and attrition from market. Major infectious diseases causing morbidity/mortality in Ghana malaria, tuberculosis, HIV/AIDS. In this study, plant medicines commonly used to treat/manage these were investigated their potential modulate rat cytochrome P450 enzyme activities. Fluorescence high-performance liquid chromatography–based assays assess effects of antimalarial medicines, Fever (FEV), Mal-TF (MAL), Kantinka terric (KT); anti-TB...
Levodopa is routinely co-administered with carbidopa in the management of Parkinson’s disease. Although aforementioned combination therapy effective, there may be fluctuating plasma levels levodopa after oral administration. We formulated and evaluated kinetic characteristics chitosan-pectin-based multiparticulate matrix carbidopa. Pectin was extracted from cocoa husk, prepared by wet granulation. Formulations were for drug-excipient compatibility, drug content, precompression properties...
The main aim of this study was to investigate levels total aflatoxin and M
Abstract Objective Dietary selenium (Se) deficiency is associated adverse pregnancy outcomes. We sought to determine the feasibility of: (1) assessing dietary Se consumption via administration of a food frequency questionnaire (FFQ) pregnant women attending antenatal clinic Korle Bu Teaching Hospital (KBTH) in Accra, Ghana and (2) quantifying total intake. Methods In this prospective observational cohort study, participants were recruited purposive sampling face-to-face data collection was...
Routine instrument failures incur extra costs that can be avoided if the is properly and consistently maintained. Due to poor maintenance cultures, scarce service engineers, lengthy shipment procedures for spare parts, other factors in developing countries, most equipment, specifically HPLC, does not work at full capacity. This short communication highlighted three challenges way forward handling issue countries.
Fish is an important source of protein, however as human impacts on the environment through industrialization, mining and farming among others resulting in increased concentration toxic metals them.The levels copper (Cu), arsenic (As), zinc (Zn), lead (Pb), cadmium (Cd), mercury (Hg), selenium (Se) were analysed fish samples from southwestern coast Ghana using acid digestion atomic absorption spectrophotometer method.A total 71 species sampled where 35 collected wet season (October, 2014)...