A5025503039- Phytochemical Studies and Bioactivities
- Identification and Quantification in Food
- Computational Drug Discovery Methods
- Proteoglycans and glycosaminoglycans research
- Natural product bioactivities and synthesis
- Bee Products Chemical Analysis
- Synthesis and bioactivity of alkaloids
- Malaria Research and Control
- Healthcare and Venom Research
- Click Chemistry and Applications
- Drug-Induced Hepatotoxicity and Protection
- Herbal Medicine Research Studies
- Dye analysis and toxicity
- Phytochemistry and Bioactivity Studies
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Phenothiazines and Benzothiazines Synthesis and Activities
- Carbohydrate Chemistry and Synthesis
- Chromatography in Natural Products
- Bioactive natural compounds
- Synthesis and biological activity
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Berberine and alkaloids research
- Food Safety and Hygiene
Kwame Nkrumah University of Science and Technology
2013-2025
Kwame Nkrumah University
2019-2023
University of Münster
2017-2019
Abstract Alpha-onocerin is a triterpenoid derived from Huperzia phlegmaria which used in ethnomedicine for the treatment of fever, headaches, pains and malaria. This study was conducted to evaluate safety, antipyretic anti-plasmodial activity alpha-onocerin artesunate (ART) co-administration ICR mice use traditional medicine. The effects (10, 30, 100, 300 mg/kg) ART (1, 2, 4, 8, 16 were assessed P. berghei -infected mice. /ART administered with fixed dose combination their median effective...
Extracts from the roots of Ononis spinosa L. (restharrow roots) are traditionally used for treatment patients with urinary tract infections due to its mild diuretic activity, caused by inhibition renal human hyaluronidase-1 isoflavonoids. Preliminary studies also indicated antiinflammatory effects. The following study aimed at investigating potential anti-inflammatory effects restharrow extracts, prepared solvents different polarity. A dichloromethane extract (OS1), mainly composed...
The challenges concerning the control of malaria remain due to continuous emergence drug resistant strains. Over years, use, misuse, and abuse antimalarials have created a conducive environment for development Plasmodium falciparum We herein report on synthesis, characterization antimalarial activity library seven novel 1,2,3-triazoles as part discovery campaign against drug-resistant falciparum. interactions triazoles with plasmepsin II, IV, falcipain-2 heme detoxifying protein-all key...
Background: Ischuria is a health and social problem, having negative impact on sufferers. This study therefore was preliminary investigation of the ischuretic property safety for use hydro-ethanolic extract Amaranthus spinosus used traditionally in managing ischuria.Methods: Phytochemical screening, thin layer chromatography high performance liquid were performed to establish fingerprints identification. Acetylcholine, Nicotine, applied an isolated rat urinary bladder ascertain contractile...
Tomato paste is the most consumed tomato product on Ghanaian market, majority of which are imported into country. This food easily adulterated, and thus, routine quality checks necessary. Therefore, current study aimed at assessing eight products market checking for presence starch artificial colourant erythrosine as possible adulterants. Routine metrics such pH, titratable acidity, total solids, soluble solids were assessed using standard methods. An HPLC method was employed to detect...
Abstract Background Herbal medicines used for male sexual disorders are widespread across the globe and have been noted as likely candidates adulteration. To assure access to safe quality herbal products, this study aimed at sampling some capsules indicated vitality analytical checks. Methods sampled from two regions were subjected physicochemical assessment, using pharmacopeial regulatory standards. Microbial analysis was also performed on selected products. A validated HPLC method...
Diabetes is a disease characterized by high post-prandial glucose levels, which lead to other complications such as peripheral end organ damage. The use of enzyme inhibitors in the management Type-2 diabetes ensure control blood levels via carbohydrate metabolism. standard agents acarbose associated with unwanted side effects hence need investigate sources antihyperglycemic agents. Propolis, natural substance from bees, possesses diverse biological activities including antioxidant,...
Alstonia boonei De Wild is a common plant in West Africa used traditional medicine for various indications. While the stem bark has frequently been investigated, not much known about phytochemistry and bioactivity of leaves. Within current study, major alkaloids hydroethanolic leaf extract were therefore isolated characterized by MS, NMR, ECD. This led to identification alstoboonine 1, new ulean-type alkaloid, along with eight previously reported indole alkaloids, 15-hydroxyangustilobine A...
To meet the growing demand for complementary and alternative treatment malaria, manufacturers produce several antimalarial herbal medicinal products. Herbal products regulation is difficult due to their complex chemical nature, requiring cumbersome, expensive, time-consuming methods of analysis. The aim this study was develop a simple spectroscopic method together with chemometric model classification identification expired liquid Principal component analysis successfully used distinguish...
A hybrid of six (6) 4-hydroxyindole azo compounds was synthesised by the diazotization and coupling strategy via electrophilic aromatic substitution reaction. Characterisation Infrared UV-Vis spectroscopic studies carried out antimicrobial activity structure-activity relationship were explored. Amongst compounds, 4d most active against Pseudomonas aeruginosa than other organisms from high-throughput spot culture growth inhibition (HTSPOTi) assay. According to resistant modulation study, did...
In this study, we investigate the effect of solvent and source Ghanaian propolis on parameters such as total phenolic flavonoid contents, chromatographic profile, antioxidant α-amylase inhibitory effects with aim identifying characterising most promising extract which could be direct or indirect benefit in management type-2-diabetes.Combinations water, ethanol-water ethanol extracts were prepared from three regions. Physicochemical characterization was perfomed using standard methods....
Humane Hyaluronidase-1 (Hyal-1) ist ein Enzym, das an der Regulation extrazellulären Matrix beteiligt ist, indem es in Gleichgewicht zwischen Ablagerung und Abbau von Hyaluronsäure (HA) im Gewebe eingreift. Inhibitoren Hyal-1 werden als aussichtsreiche Verbindungen zur Geweberegeneration gesehen, können aber auch Niere Induktion diuretischen Effekten geprüft werden. Durch Verwendung oberflächenpräsentierter humaner auf E. coli-F470-Zellen [1], HA Substrat Stains-all-Verfahren Quantifizierung...
Wurzelextrakte aus Hauhechel (Ononis spinosa L.) werden traditionell bei Infektionen der ableitenden Harnwege eingesetzt. Eine verringerte Ödembildung im Carrageenan-induzierten Rattenpfotenödemtest deutete außerdem auf eine antiinflammatorische Wirkung in vivo hin [1]. Neuere Untersuchungen zeigten, dass es sich beim Isoflavon Sativanon um einen potenten Inhibitor humanen Hyualuronidase-1 handelt, einem Enzym, das eng mit einer Induktion inflammatorischen Zellantwort Zusammenhang steht [2]....
Extracts from the roots of Ononis spinosa L. are traditionally used for urinary tract infections and rheumatic conditions. A reduction oedema in carrageenan-induced rat paw test suggested an anti-inflammatory activity vivo [1]. Recent investigations indicated isoflavone sativanone to be a potent inhibitor human hyaluronidase-1, enzyme strongly related induction inflammatory cellular response [2]. During further investigations, dichloromethane extract fully characterized by LC-MS studies...
Isolation and identification of secondary metabolites from medicinal plants could be tedious time consuming. Therefore, any technique that used to confirm the identity plant constituents without isolating them will save resources. Chlorophora similar many genera in Moraceae family have been demonstrated rich sources polyphenolic compounds with important biological activities. The current study was designed employ HRESI-MSn analyses qualitatively examine isolated stem bark regia. Based on...