A5005797869- Click Chemistry and Applications
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Computational Drug Discovery Methods
- Analytical Methods in Pharmaceuticals
- Pituitary Gland Disorders and Treatments
- Catalysis for Biomass Conversion
- Analytical Chemistry and Chromatography
- Ion channel regulation and function
- Drug Solubulity and Delivery Systems
- Moringa oleifera research and applications
- Microbial Metabolic Engineering and Bioproduction
- Antimicrobial agents and applications
- HIV/AIDS drug development and treatment
- Neuroscience and Neuropharmacology Research
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Epilepsy research and treatment
- Hormonal Regulation and Hypertension
- Analytical Chemistry and Sensors
- Bacteriophages and microbial interactions
- Inorganic and Organometallic Chemistry
- Adrenal Hormones and Disorders
- Biofuel production and bioconversion
University of North Texas
2024
University of North Texas System
2024
University of North Texas Health Science Center
2024
University of Health and Allied Sciences
2017-2022
Kwame Nkrumah University of Science and Technology
2017
Gain-of-function mutations in the KCNT1 gene, which encodes sodium-activated potassium channel known as SLACK, are associated with rare but devastating developmental and epileptic encephalopathy epilepsy of infancy migrating focal seizures (EIMFS). The design small molecule inhibitors SLACK channels represents a potential therapeutic approach to treatment EIMFS, other childhood epilepsies, disorders. Herein, we describe hit optimization effort centered on xanthine inhibitor (8) discovered...
An isocratic sensitive and precise reverse phase high-performance liquid chromatography (RP-HPLC) method was developed validated for the determination quantification of hydrocortisone in controlled-release conventional (tablets injections) pharmaceutical preparations. Chromatographic separation achieved on an ODS (C18), 5 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>μ</mml:mi></mml:mrow></mml:math>m, 4.6 × 150 mm, with elution using a freshly prepared...
The challenges concerning the control of malaria remain due to continuous emergence drug resistant strains. Over years, use, misuse, and abuse antimalarials have created a conducive environment for development Plasmodium falciparum We herein report on synthesis, characterization antimalarial activity library seven novel 1,2,3-triazoles as part discovery campaign against drug-resistant falciparum. interactions triazoles with plasmepsin II, IV, falcipain-2 heme detoxifying protein-all key...
The use of herbal therapy is a common practice in Africa. One the commonly used herbs Vernonia amygdalina. Processing plant for leads to loss phytochemical principles like saponin which has been shown possess bioactivity. This study was evaluate and characterize principles, using chromatographic spectroscopic techniques. Standard antipyretic procedure Saccharomyces cerevisiae induced pyrexia rats evaluation aqueous extract, as well as, crude its fraction. separation chromatogram development...
A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however, used synthesize 1-, 2-, and 3-triazole intermediates as tether for hybrid salts. Their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus Enterococcus faecalis), Gram-negative (Escherichia coli Pseudomonas aeruginosa), Mycobacterium smegmatis mc2155 determined using HT-SPOTi assay. Compound 2 showed most...
Common cold medicines usually present as multi-component products and constitute one of the largest groups 'over-the-counter' marketed in Ghana. Due to their wide patronage easy accessibility, quality control is utmost importance medicine consumers. In this study, Design Experiment (DOE) concept adopted develop a chromatographic method for simultaneous assay pseudoephedrine hydrochloride chlorphenamine maleate commercially available products. The separation drugs was achieved on an Agilent...
A hybrid of six (6) 4-hydroxyindole azo compounds was synthesised by the diazotization and coupling strategy via electrophilic aromatic substitution reaction. Characterisation Infrared UV-Vis spectroscopic studies carried out antimicrobial activity structure-activity relationship were explored. Amongst compounds, 4d most active against Pseudomonas aeruginosa than other organisms from high-throughput spot culture growth inhibition (HTSPOTi) assay. According to resistant modulation study, did...
4-(2-(2,4-Dinitrophenyl) hydrazone) methyl)-2 methoxy phenol (IND-X) and 4-(2-(2, 4-dinitrophenylhydrazono) methyl) benzene-1,3-diol (IND-Y) were synthesised by condensation reactions with 2,4-dinitrinophenylhydrazine observed to possess acid-base indicator properties. The study was conducted explore verify their use in different analytical situations and, consequently, validate them. Analysis of titrations between strong acids/strong bases weak as well pharmaceutical applications the assay...
Processing of food products makes them palatable, edible, provides options to consumers and prolong their life spans. Irrespective these benefits, some processes have also shown increase the build-up potential toxic metabolites, for example, 5-hydroxymethylfurfural (5-HMF). 5-HMF production results from caramelization and/or Maillard reactions involving carbohydrates proteins. Its levels are thus used as an indicator thermal treatment suitability storage conditions. At significantly, higher...
Introduction: Antimicrobial resistance has increasingly been a global health concern over the past decades and that necessitated quest to increase pool of antibiotics.
 Methods: Five (5) azo compounds were synthesised by diazotization coupling procedures with yields 60 – 92%. They characterized melting point determination, Ultra-Violet Visible, Infra-red spectroscopy. High-throughput spot culture growth inhibition (HT-SPOTi) antimicrobial assay was used evaluate compounds. Computational...