The physicochemical and antimicrobial properties of cocoa pod husk (CPH) pectin intended as a versatile pharmaceutical excipient nutraceutical were studied. Properties investigated include pH, moisture content, ash values, swelling index, viscosity, degree esterification (DE), flow properties, SEM, FTIR, NMR, elemental content. Antimicrobial screening determination MICs against test microorganisms undertaken using agar diffusion broth dilution methods, respectively. CPH had DE 26.8%...

Purpose: This study presents a novel and sustainable approach to cancer therapy by combining halloysite nanotubes (HNTs), green‐synthesized copper oxide (CuO) nanoparticles, curcumin (CUR). We demonstrate that the green synthesis of CuO when combined with CUR incorporated into HNTs, enhances delivery anticancer effects CUR. innovative complex could address some critical limitations current therapies such as poor pharmacokinetics drug resistance providing controlled release mechanism...

The quality of 68 samples 15 different essential children’s medicines sold in licensed medicine outlets the Ashanti Region, Ghana, was evaluated. Thirty-two (47.1%) were imported, mainly from India (65.6%) and United Kingdom (28.1%), while 36 (52.9%) locally manufactured. assessed using content active pharmaceutical ingredient (API), pH, microbial limit tests, results compared with pharmacopoeial standards. Twenty-six (38.2%) studied passed official API test 42 (61.8%) failed. Forty-nine...

Research indicates an increased use of hand sanitizers globally, and in particular developing countries where bacterial epidemics such as cholera are common. While there is evidence availability, high demand sanitizers, the incidence remains unabated. Several reasons have been put forward, cost dominant. It response to this contradictory situation availability but limited access, that study was conducted present alternative option formulating a quality effective ethanol-based sanitizer from...

Obesity and overweight are metabolic disorders associated with oxidative stress, risk factors for many chronic diseases. We sought to investigate the effects of Metaswitch dietary supplement on weight gain acute alterations in a high-fat diet-induced rat model.Female Sprague Dawley (SD) rats were put into 6 groups. Control groups fed normal (NCD) or diet (HFD). Treatment HFD receieved 3 different daily doses weeks. Another group received Slimrite® (phenylpropanolamine), standard drug. Rats...

An isocratic sensitive and precise reverse phase high-performance liquid chromatography (RP-HPLC) method was developed validated for the determination quantification of hydrocortisone in controlled-release conventional (tablets injections) pharmaceutical preparations. Chromatographic separation achieved on an ODS (C18), 5 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>μ</mml:mi></mml:mrow></mml:math>m, 4.6 × 150 mm, with elution using a freshly prepared...

Management of diarrhea has evolved over the years from relatively inadequate interventions in early to more successful physiological approaches. The use herbal medicinal products and supplements grown significantly past three decades, with than half global population depending on it for some aspect their primary health care needs. This study is aimed at formulating solid liquid oral dosage forms ethanolic extract Cola nitida seeds treatment diarrhea. flow property dried was determined...

Elimination of microorganisms from herbal products has been a major concern due to its implicated health risk consumers. Drying materials employed for centuries reduce the contamination and spoilage. The present study adopted three drying approaches in an attempt eliminate Lippia multiflora tea bag formulation. This also evaluated bags optimized extraction procedure. L. leaves bagging were air-dried milled (A), oven-dried (B), microwaved (the leaves) (C). moisture contents determined at...

Herbal medicines are currently being adopted as alternatives to orthodox for the management of drug-resistant and emerging multidrug-resistant microbial strains various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by Centre Plant Medicine Research (CPMR), has been used treatment fever at least two decades in Ghana with desirable outcomes. 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium...

Postpartum depression is a mood disorder that affects about 9-20% of women after child birth. Reports suggest gestational iron deficiency can cause deficit in behavioral, cognitive and affective functions precipitate depressive symptoms mothers during the postpartum period. The present study examined effect supplementation on behavior period rat model.Female Sprague-Dawley rats were crossed. Pregnant received iron, fluoxetine, desferrioxamine or vehicle throughout gestation. During period,...

Background/Aim: Depression-related aggression is linked to serotonin (5-HT) and dendritic spine alterations. Although Mallotus oppositifolius extract (MOE) has potential for reducing this effect, its specific role remains uncertain. Herein, we evaluated associated alterations in the brain. Methods: A standard resident-intruder model of para-chlorophenylalanine (pCPA)-induced depression-associated male ICR mice was used. The resident received pCPA (300 mg/kg, i. p.) 3 consecutive days while...

Modern advances in dosage forms require innovative excipients that make them more efficient than conventional forms. Natural like gums are known to be cheap, biodegradable, and readily available. However several natural yet fully characterized utilized. This study sought determine the physicochemical properties of Piptadiniastrum africana (Hook. F.) gum establish a basis for its pharmaceutical application. The crude (CPAG) was collected as exudates from tree bark observed macroscopic...

is a monoherbal decoction produced by the Centre for Plant Medicine Research (CPMR), Mampong-Akuapem, Ghana. It prepared from stem bark of

Conventionally, the microorganisms in liquid herbal mixtures are curtailed due to fresh preparation before administration patients. Prolonged storage of preparations (due commercialization) coupled with primeval routine production processes may increase potential microbial contamination preparations. This study aims analyze quality 15 selected commercial on Ghanaian market. The samples were obtained from accredited pharmacies and outlets Greater Accra region Ghana, specifically Central...

Natural polymer research has recently become the focus of intensive in quest for new enabling excipients novel drugs pharmaceutical formulation optimal treatment outcomes. Evaluations some have shown deleterious haematological effects varying extents on safety profile these excipients. A 90-day subchronic toxicity study was conducted to evaluate influence cocoa pod husk (CPH) pectin indicators haematotoxicity. Male and female Sprague Dawley rats (SDRs) were fed with CPH doses up 71.4 mg/kg....

Formulation and evaluation of Salbutamol sulphate microspheres by solvent evaporation methodV.V Prasanth, Akashmoy Chakraborty, Sam T Mathew, Rinku Mathappan, V. Kamalakkannan

Carbamazepine is a drug used in the treatment of neurological disorders such as epilepsy. However, due to its erratic absorption, oral bioavailability often poor. There is, therefore, need develop alternative formulations for carbamazepine with better pharmacokinetic characteristics.The aim this study was formulate an modified-release multiparticulate matrix from cocoa pod husk (CPH) pectin and evaluate profile formulation using vitro vivo models.CPH extracted husks hot aqueous citric acid...

This study evaluated the

Context: Excipients play a key role in the quality of medicines and contribute to viable delivery systems. This has intensified search for new natural polymer pharmaceutical excipients. Cocoa pod husks (CPHs) are rich source pectin. A study CPH pectin showed that it possesses requisite physicochemical properties be employed as multi-functional excipient. However, safety this not been evaluated. Aims: To conduct sub-chronic toxic effects Sprague Dawley rats assess its grade Methods: at doses...

Abstract Background Diabetes Mellitus (DM) is a major health problem, with global prevalence of 9.3%, 4.7% in Africa, and 2.5% Ghana. Despite the availability classic anti-diabetic medications, many patients have not benefited from them due to their poor glycemic controls, high costs, inability halt disease progression, untoward side effects. Some thus resort plant-based medicines such as those obtained L. taraxacifolia etc., which little empirical evidence efficacy. Therefore, this study...

The potential of cocoa pod husk (CPH) pectin-based modified release (MR) capsules as a carrier for chronodelivery hydrocortisone in Sprague-Dawley rats was assessed. Extemporaneously formulated CPH (10 mg) crosslinked with calcium chloride (Formulation A) or zinc B) and commercial immediate formulation were administered orally to the pharmacokinetic parameters evaluated using noncompartmental analysis. Formulation A had 2 h lag phase followed by an increase serum drug concentration treated...

Aim: To assess the quality and in vitro efficacy of five brands amoxicillin/clavulanic acid tablet, suspension injectable preparations selected from pharmacies Central Region Ghana. Method: Using a Stratified Representation Sampling method, forty (tablets, suspensions powders) containing amoxicillin clavulanic were sampled nine different locations within determine drug quality, several procedures, namely, content assay, disintegration dissolution testing employed. In was determined by...

Aim: To evaluate in vitro the effectiveness of several anti-infective agents alone or combination against Mycobacterium smegmatis. Method: A convenient stratified sampling method was used to obtain selected agents. For individual drug samples, Minimum Inhibitory Concentrations (MIC) were obtained using agar-well plate diffusion technique. Fractional Concentration Indices (FICI) calculated for combinations their MIC as from broth dilution method. Results: Of thirty (30) analyzed, ten (10) had...