A5009137451- Ethnobotanical and Medicinal Plants Studies
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Malaria Research and Control
- Essential Oils and Antimicrobial Activity
- Moringa oleifera research and applications
- Phytochemistry and biological activities of Ficus species
- Liver Disease Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Bioactivity Studies
- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Mycobacterium research and diagnosis
- Natural product bioactivities and synthesis
- Pharmacogenetics and Drug Metabolism
- Morinda citrifolia extract uses
- Parasites and Host Interactions
- Pharmacology and Obesity Treatment
- Bioactive natural compounds
- Trypanosoma species research and implications
- Heavy metals in environment
- Medicinal Plants and Neuroprotection
- Metabolism, Diabetes, and Cancer
- Phytochemistry and biological activity of medicinal plants
University of Ghana
2015-2025
University of Ibadan
2024
Duke University
2024
University of Ilorin
2024
University of Nigeria
2024
Wake Forest University
2024
University of Kentucky
2024
Noguchi Memorial Institute for Medical Research
2013-2023
ORCID
2021
University of Bahrain
2014
In a continuing study of curcumin analogues as potential drug candidates to treat prostate cancer at both androgen-dependent and androgen-refractory stages, we designed synthesized over 40 new classified into four series: monophenyl (series A), heterocycle-containing B), bearing various substituents on the phenyl rings C), with linkers D). These compounds were tested for cytotoxicity against two human cell lines, LNCaP androgen-independent PC-3. Antiandrogenic activity was also evaluated in...
Peptic ulcer is among the most serious gastrointestinal diseases in world. Several orthodox drugs are employed for treatment of disease. Although these effective, they produce many adverse effects thus limiting their use. In recent years, there has been a growing interest alternative therapies, especially those from plants due to perceived relative lower side effects, ease accessibility, and affordability. Plant medicines with ethnomedicinal use peptic management need be screened...
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Aims: The current study was designed to document medicinal plant species that are traditionally used treat tuberculosis (TB) by Ghanaian communities.Methods: plants against TB or its signs and symptoms were selected using library online published data searches. A guided questionnaire interview also conducted with a botanist involved in collection at the Centre for Scientific Research into Plant Medicine (CSRPM) Mampong. Data obtained entered Excel summarized means frequencies SPSS 12.0.1...
Moringa oleifera is a multipurpose plant used in Ghana and most parts of Africa. Its high mineral, protein, vitamins content has enabled its use as nutraceutical panacea for various diseases. This study aimed at measuring the micro- macroelements dried leaves using energy dispersive X-ray fluorescence spectroscopic (EDXRF) assessing toxicological effect rats. Acute toxicity (5000 mg/kg) subacute studies leaf (40 mg/kg to 1000 extract were conducted Blood samples assessed biochemical...
Stress among pharmacy students could greatly affect their learning activities and general well-being. It is therefore necessary to investigate how stress relates with the quality of life maintain and/or improve personal satisfaction academic performance. A school-based longitudinal study was used relationship between undergraduate students. The 10-item perceived scale shorter version WHO were administered same participants at two time points i.e. Time 1 (4 weeks into semester) 2 (8...
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains an ongoing threat to human health. Several medicinal plants are used traditionally treat in Ghana. The current study was designed investigate the antimycobacterial activity and cytotoxicity of crude extracts from five selected plants.The microplate alamar blue assay (MABA) for studies while CellTiter 96® AQueous Assay, which is composed solutions a novel tetrazolium compound...
Acute toxicity studies of aqueous leaf extract Phyllanthus niruri is a plant with medicinal properties. It often used to treat mild malaria and the elimination renal stones. However, on its are scarce. The study was carried out determine if P. administered female Sprague-Dawley rats would illicit evidence toxicity. Fifteen weighing 150-200 g were divided into 3 groups. Rats in Group 1 given single low dose (LD) 2 000 mg/kg b.w. by oral gavage within 24 hrs. high (HD) 5 not any but drinking...
Moringa oleifera (M. oleifera), a green leafy vegetable, is good source of minerals and vitamins which could be consumed as part diet to improve human health well-being. Drying M. leaves make it readily available for use food fortificant. The objectives the study were determine micromineral β -carotene content dried leaves, leaf-incorporated local dishes, also assess school children's (4-12 yr) acceptability dishes feasibility introducing into lunch menu. solar dried, milled powder, packaged...
Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on single drug, praziquantel, motivation for the search of novel antischistosomal compounds. This study investigated anthelmintic activity stem bark and roots Rauwolfia vomitoria against two life stages Schistosoma mansoni . Both plant parts were found to active cercariae adult worms. Within 2 h exposure all killed at concentration range 62.5–1000 µ g/mL 250–1000 R. roots,...
Trypanosomiasis, leishmaniasis, and malaria are protozoan infections of public health importance with thousands new cases recorded annually. Control these infection(s) existing chemotherapy is limited by drug toxicity, lengthy parenteral treatment, affordability, and/or the emergence resistant strains. Medicinal plants on other hand used in treatment various infectious diseases although their chemical properties not fully evaluated. In this study, we screened 112 crude extracts from 72...
Mental and neurological disorders are a serious public health challenge globally, particularly in developing countries where cultural factors limited access to standard healthcare have led reliance on traditional medicines. However, ethnopharmacological characterization of medicines used treat these diseases is lacking. In this study, an ethnobotanical description plant species treating mental Ghana update their experimentally validated pharmacological relevance provided.Two hundred...
Abstract The concentration of seven heavy metals in water samples was analyzed along the southwest coast Ghana wet and dry seasons using atomic absorption spectrophotometer. Some physicochemical properties were also determined to assess quality water. ranges metal season were; As (1.23–7.84 µg/L), Cu (4.10–24.09 Pb (4.08–57.98 Se (BDL-0.38 Zn (2.86–17.75 µg/L) Hg (0.023–0.068 whereas (2.30–5.78 (25.47–70.73 (0.081–0.158 (0.79–22.80 (0.004–0.047 µg/L). results pH (6.83 7.52), EC...
Trypanosoma brucei parasites are kinetoplastid protozoa that devastate the health and economic well-being of millions people in Africa through disease human African trypanosomiasis (HAT). New chemotherapy has been eagerly awaited due to severe side effects drug resistance issues plaguing current drugs. Recently, there an emphasis on use medicinal plants worldwide. Morinda lucida Benth. is a popular plant widely distributed Africa, several research groups have reported antiprotozoal...
Abstract Resistance of Plasmodium falciparum to chloroquine has been reported in several countries. Other anti‐malarial drugs use are expensive and not readily accessible most people malaria endemic This led renewed interest the development herbal medicines that have potential treat with little or no side effects. study obtained a preliminary information on safety effectiveness plant decoction (AM‐1), used treating malaria. The AM‐1 is formulated from Jatropha curcas , Gossypium hirsutum...
Phyllanthus niruri is a medicinal plant (commonly known as stone breaker) found in the tropics and other parts of world. It for its capacity to block formation calcium oxalate crystals kidney urolithiasis. This has been used treat hyperglycemia, hypertension, pain, mild cases malaria. We examined geno-, cyto- overall toxicity P. whole ethanolic extract. The extract was administered single dose 30 or 300 mg/kg laboratory rats by gavage, accompanied negative (0.9% saline) positive (10 mg/mL...
Since both aflatoxin and the human immunodeficiency virus (HIV) cause immune suppression, chronic exposure to in HIV-positive people could lead higher levels of replication. This study was conducted examine association between B 1 albumin adduct (AF-ALB) HIV viral load. Antiretroviral naive (314) with median CD4 count 574 cells/μl blood (mean ± standard deviation = 630±277) were recruited Kumasi, Ghana. Sociodemographic health data, samples collected from participants. The plasma tested for...