A5078963651- Ethnobotanical and Medicinal Plants Studies
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Cholesterol and Lipid Metabolism
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Mangiferin and Mango Extracts
- Pharmacological Effects of Natural Compounds
- Wound Healing and Treatments
- NF-κB Signaling Pathways
- Phytochemistry and Bioactivity Studies
- Malaria Research and Control
- Head and Neck Cancer Studies
- Pharmacogenetics and Drug Metabolism
- Psidium guajava Extracts and Applications
- Pharmaceutical Quality and Counterfeiting
- Phytochemistry and biological activities of Ficus species
- Analytical Methods in Pharmaceuticals
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Ziziphus Jujuba Studies and Applications
- HIV/AIDS drug development and treatment
- RNA regulation and disease
- Bioactive Natural Diterpenoids Research
- Zoonotic diseases and public health
University of Cape Coast
2015-2025
University of Pretoria
2017-2020
University of Ghana
2012
Phyllanthus niruri is a medicinal plant (commonly known as stone breaker) found in the tropics and other parts of world. It for its capacity to block formation calcium oxalate crystals kidney urolithiasis. This has been used treat hyperglycemia, hypertension, pain, mild cases malaria. We examined geno-, cyto- overall toxicity P. whole ethanolic extract. The extract was administered single dose 30 or 300 mg/kg laboratory rats by gavage, accompanied negative (0.9% saline) positive (10 mg/mL...
The inhibition of reactive oxygen species (ROS) and the migration fibroblasts are key processes involved in wound healing. In this study, ability aqueous ethnomedicinal plant extracts prepared from Aspilia africana CD Adams, Boerhavia diffusa L. Erythrina senegalensis DC. to mediate fibroblast ROS release was determined. Phytochemical composition assessed using thin-layer chromatography (TLC), whereas phytochemical markers were detected ultra-performance liquid coupled time flight mass...
Abstract Objectives Whole plants of Boerhavia diffusa L. are widely used medicine in Ghana and other tropical countries, for the treatment wounds ailments. The aim study was to determine ability sequential extracts B. influence oxidation wound closure myoblast cells vitro. Methods Sequential were prepared from whole plant using four solvents increasing polarity (hexane, ethyl acetate, methanol water). Cytotoxicity determined sulforhodamine B staining assay, phase-contrast microscopy, plasDIC...
Abstract Objectives Ziziphus abyssinica (ZA) is employed in managing several ailments Traditional African Medicine. Scientific evaluations are necessary to ascertain the medicinal potential of ZA as a source new drug molecules. This study investigated possible therapeutic benefit leaf (ZAL) and root bark (ZARB) extracts an experimental model multi-organ injuries induced by phenylhydrazine (PHZ). Methods Hyperbilirubinaemia, hepatotoxicity, nephrotoxicity splenic were pretreating albino rats...
Background: Antimicrobial resistance has rendered several anti-infective agents ineffective, necessitating the need to intensify efforts identify and develop novel drugs against microbial infection. Structural modification of existing antibiotics continues be one areas intense research focus in recent times. Objective: This study assessed antibacterial synergistic activity fifteen pyrazolyl sulphonamide derivatives Staphylococcus haemolyticus. Methods: Antibacterial was determined using...
What would it take in terms of the structural reforms science, technology, and culture to cultivate sustainable therapeutic preventive medicine innovations against zoonotic infections such as coronavirus disease 2019 (COVID-19) 21st century? In May 2019, Intergovernmental Science-Policy Platform on Biodiversity Ecosystem Services warned that "around one million animal plant species are now threatened with extinction." is essential for drug discovery development. We currently facing a dual...
Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolaemia associated with CCl 4 -induced hepatic injury in rats without improving liver function our previous study. This present study investigated lipid lowering potential celecoxib normal fed coconut oil subjected to five deep-frying episodes. Male Sprague Dawley were randomly assigned groups (n = 6 rats/group) which received physiological saline (10...
Context: Erythrina senegalensis (ES) DC. is used traditionally in the management of various free radical-related diseases, including wound healing. Aims: To evaluate sequentially prepared leaf extracts ES for ability to protect against oxidative stress fibroblasts and macrophages. Methods: Sequential were using hexane, ethyl acetate, methanol water increasing polarity. Chemical profiling was done with ultra-performance liquid chromatography coupled mass spectrometry (UPLC-MS). Cytotoxic...
An onsite technique for determining drug integrity in sub-Saharan Africa is needed ensuring and enhancing public health.
<h3>Background</h3> Malaria/HIV co-infection (MHC) is a public health challenge which may present with worse outcomes due to interactions. Coadministration of artemether lumefantrine (ALU) and antiretroviral therapy have potential drug-drug interactions that can affect the course treatment for both diseases. Generic ALU medications are used in Ghana malaria after RDT or microscopy diagnosis. metabolized by enzymes CYP2B6, CYP3A4/5, CYP2A6 UGTs be affected pharmacogenetics. A better...
Background: Ethnomedicinal preparations have for many years served as medication treatment of diverse diseases. These possess various pharmacologically-active phytochemicals which may be harnessed the diseases such wounds. This study investigated ability ethnomedicinal extracts prepared from Aspilia africana CD Adams, Boerhavia diffusa L. and Erythrina senegalensis DC. to alter reactive oxygen species (ROS) release cellular migration in SC-1 fibroblasts surrogate markers wound healing.
Background: Guiera senegalensis (Ghibaish) is a medicinal plant extensively used in central and west Africa for the management of various diseases.Aim: This study aimed to determine antioxidant activity ethanol leaf extract plant.Method: The was sequentially sub-fractionated using liquid–liquid extraction, vacuum-liquid chromatography preparative thin layer chromatography. Ultra-performance liquid with accurate mass spectrometry nuclear magnetic resonance were employed isolate confirm...
Abstract Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolemia associated with CCl 4 -induced hepatic injury in rats without improving liver function our previous study. This present study investigated lipid lowering potential celecoxib normal fed coconut oil subjected to five deep-frying episodes. Male Sprague Dawley were randomly assigned groups (n=6 rats/group) which received physiological saline...