A5103157864- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Cassava research and cyanide
- Lymphoma Diagnosis and Treatment
- NF-κB Signaling Pathways
- Diabetes Treatment and Management
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- COVID-19 and healthcare impacts
- Cancer-related gene regulation
- Phytochemistry and Bioactivity Studies
- Heavy Metal Exposure and Toxicity
- Blood Pressure and Hypertension Studies
- Iron Metabolism and Disorders
- Nitric Oxide and Endothelin Effects
- Phytochemical compounds biological activities
- Parasite Biology and Host Interactions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Glutathione Transferases and Polymorphisms
- Parasites and Host Interactions
- Trace Elements in Health
University of Cape Coast
2020-2024
Heavy metal toxicity contributes to liver and kidney dysfunction damage through oxidative stress mechanisms; however, from previous studies, extracts the Vernonia amygdalina plant have shown possess potent antioxidant properties. This study was aimed at uncovering potential ameliorative effects of ethanolic extract in heavy toxicity-induced dysfunction. For this study, 44 Sprague Dawley rats were divided into three groups. The control group received a basal diet water only while treatment...
Head and neck tumors (HNT) are that normally occur at the head region of body. Epidermal growth factor receptor (EGFR) has been found to be highly expressed in breast other tumors; therefore, there is need investigate level EGFR expression among patients with Ghana.The was determined tumor control tissues quantitative real-time PCR immunohistochemistry analysis.The expressions high than tissues. There a significant difference p value 0.025 ages >40 ≤ 40 when low compared malignant tumor. The...
Background Head and neck tumors (HNT) are of the paranasal sinuses, salivary glands upper aerodigestive tract. RIN1 is a Ras effector protein regulating epithelial cell properties has been implicated in number cancers. Method The aim this study was to investigate expression head tumors. assessed using quantitative real-time PCR (qRT-PCR) immunohistochemical staining on archival tissue samples between 2014 2020. Results low as compared with normal tissues. High levels were ages ≤40, >40...
Abstract Head and neck tumors (HNT) are of paranasal sinuses origin (the salivary glands the upper aerodigestive tract). It constitutes sixth most common tumors. Studies have shown that, factors such as tobacco alcohol intake viral infections may increase relative risk to tumor. Notch1 pathways frequently altered in many tumors, however, clinical significance NOTCH1dysregulation head is poorly understood. METHOD: The aim this study was investigate expression NOTCH1 tumor also elucidate...
Abstract Background Plasmodium falciparum and Hookworm infections are prevalent in West Africa they cause iron deficiency anemia protein malnutrition Children. Immune response of these parasites interact their interactions could have repercussions on vaccine development efficacy. The current goal hookworm eradication lies vaccination. We evaluated the effect P. coinfection albendazole treatment naturally acquired antibody profile against L3 stage larvae antigen. Methods In a longitudinal...
Abstract Nrf2/BACH1/HO-1 signals have been implicated in the development and progression of tumors. However, there has no comprehensive analysis their expressions breast cancer. This study evaluated expression its clinical significance 114 female cancer different pathologic parameters non-cancerous tissues were for using immunohistochemistry western blot. The relationship connecting clinicopathologic factors assessed chi-square test. Nrf2 protein cancerous (74%) was significantly higher than...
Background: Growth hormone-releasing peptides (GHRP) have been reported to possess cardioprotective properties; nonetheless, their mechanisms of action are still not very clear. Objectives: Some studies suggested that modulation endothelial nitric oxide synthase (eNOS) and the upregulation (NO) cardioprotective. Therefore, present study strived test hypothesis a potent GHRP analog (hexarelin) could increase serum level regulate myocardial eNOS alleviate development heart failure. Methods:...