A5028713082- Urinary Bladder and Prostate Research
- Plant Toxicity and Pharmacological Properties
- Endoplasmic Reticulum Stress and Disease
- Blood Pressure and Hypertension Studies
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac, Anesthesia and Surgical Outcomes
- Birth, Development, and Health
- Prenatal Substance Exposure Effects
- Hormonal and reproductive studies
- Cannabis and Cannabinoid Research
- Cancer Mechanisms and Therapy
- Aluminum toxicity and tolerance in plants and animals
- Oil Palm Production and Sustainability
- Liver physiology and pathology
- Lipid Membrane Structure and Behavior
- Prostate Cancer Treatment and Research
- Heavy Metal Exposure and Toxicity
- Cancer-related Molecular Pathways
- Reproductive Health and Contraception
- Fatty Acid Research and Health
- Coconut Research and Applications
- Bioactive Natural Diterpenoids Research
- Medicinal Plants and Bioactive Compounds
Sahlgrenska University Hospital
2024-2025
University of Gothenburg
2024-2025
University of Health and Allied Sciences
2016-2024
University of Ghana
2014-2024
University of the Witwatersrand
2021-2023
Korle Bu Teaching Hospital
2015-2021
University of Bahrain
2013
Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community George A Asare,1 Sheila Santa,1 Robert Ngala,2 Bernice Asiedu,1 Daniel Afriyie,3 Albert GB Amoah4 1Department Medical Laboratory Sciences, University Ghana School Allied Health Sciences (SAHS), Korle-bu, Ghana; 2Department Molecular Medicine, Kwame Nkrumah Science Technology, Kumasi, 3Department Pharmacology, 4Department School, Background: Hormonal (HCs) have been shown...
The etiology of benign prostatic hyperplasia (BPH) remains a mystery to scientists; estrogen/androgen imbalance in aged men has been implicated.Thirty (30) apparently healthy and newly diagnosed BPH patients were recruited from the Ghana Police Hospital. Lower urinary tract syndrome (LUTS) prostate volume assessed via symptom score sheet (IPSS) abdominopelvic scan, respectively. Laboratory assays for total specific antigen (tPSA) hormones [androstenedione (AED), testosterone (T),...
Background: The safety of combining tamsulosin (an allopathic drug) and Croton membranaceus aqueous extract, a medicinal plant for managing benign prostatic hyperplasia (BPH), was investigated. Methods: roots CM were used processed into water extract by maceration decoction. Thirty‐five Sprague Dawley rats divided seven groups five each. Groups 2–7 orchidectomy/testosterone injections BPH‐induced. Group 1 designated as the control group. 2 model group (untreated). 3 treated with 0.03 mg/kg...
Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) share common conditions such as lower urinary tract symptoms (LUTS) dyslipidaemia. Whether an extensive lipid profile analysis could discriminate between BPH PCa was the objective. Thirty-six (36) twenty (20) outpatients of a urology clinic plus forty (40) controls without LUTS, but normal PSA, were recruited. Body mass index (BMI), (total cholesterol [CHOL], triglycerides [TG], high-density lipoprotein [HDL], very-low-density...
AIM: The purpose of the study was to determine levels Copper (Cu), selenium (Se), Zinc (Zn), Lead (Pb) and Lithium (Li) in patients Accra Pantang Psychiatric Hospitals Ghana since no data exist.SUBJECTS AND METHODS: Simple random sampling age-matched subjects used recruit 81 schizophrenics 25 mentally healthy controls 2012. Serum Cu, Se, Zn, Pb Li were determined by flame atomic absorption spectroscopy (FAAS). RESULTS: Mean as follows: Cut 766 ± 250 µg/L Cuc 855 270 (p = 0.168). Set 149...
Calcium (Ca)- magnesium (Mg) imbalance is implicated in prostate cancer. Ca/Mg ratio increases or decreases with proliferation apoptosis, respectively. The study examined whether this exists BPH patients and the effect of a phytotherapeutic drug on ratio.Thirty (30) who used ethanolic root extract Croton membranaceus (60 mg/day) for 3 months were serum Ca, Mg, phosphate, parathyroid hormone (PTH), vitamin D, specific antigen (PSA) levels renal function tests (RFT) before (BT) after treatment...
Cardiovascular disease (CVD) accounts for 17.3 million deaths per year globally. In Ghana, CVD 22.2% of deaths. Croton membranaceus (CM) Mull. Arg. (Euphorbiaceae), a medicinal plant in Ghana is mainly used traditionally the treatment benign prostatic hyperplasia and measles. However, some hypoglycaemic hypotensive effects have recently been reported but not scientifically examined.The study aimed at establishing whether prostatitis had any effect on markers.In experiment 1, lipid profile...
Benign Prostatic hyperplasia (BPH) is one of the age-related conditions that reduce quality life in aging men. Treatment modalities range from surgical, use allopathic drugs, to phytotherapy. Allopathic drugs such as Finasteride and Tamsulosin are often considered have adverse side effects reduced libido erectile dysfunction. In some countries finasteride recommended for BPH although prefer Croton membranaceus (CM). However, indigenes combine two. The study therefore sought determine impact...
Red palm oil produced in Ghana largely by village folks has never been tested for its mutagenic potential. The study aimed at determining the mutagenicity of high-energy heated red (RRPO) and refined, bleached imported (PO) on Ghanaian market. Samples RRPO PO were 1× 5× 10 min 180 °C with a cooling period 5 h in-between. Unheated, together samples, using Salmonella typhimurium TA 98 100 tester stains. Unheated was negative Ames test strain. However, (P = 0.05, each). Testing PO, strain...
Alcohol intake at different developmental stages can lead to the development of alcohol-induced fatty liver disease (AFLD). Zingerone (ZO) possess hepato-protective properties; thus, when administered neonatally, it could render protection against AFLD. This study aimed evaluate potential long-term protective effect ZO One hundred and twenty-three 10-day-old Sprague–Dawley rat pups (60 males; 63 females) were randomly assigned four groups orally following treatment regimens daily during...
Neonatal alcohol exposure (NAE) can induce oxidative stress. We determined whether zingerone (ZO), a phytochemical with anti-oxidant activity, mitigate the negative impact of neonatal alcohol-induced Seventy ten-day-old Sprague-Dawley rat pups (35 male, 35 female) were randomly assigned and administered following treatment regimens daily from postnatal day (PND) 12–21: group 1 – nutritive milk (NM), 2 NM +1 g/kg ethanol (Eth), 3 + 40 mg/kg ZO, 4 Eth ZO. Growth performance, blood glucose...
Changing voiding patterns, volume and frequency, may sometimes be mistaken for anxiety, stress or increase in fluid consumption. In the aging male population, commencement of lower urinary tract symptoms (LUTS) silent perceived as "normal" unrelated to Benign prostatic enlargement (BPE). The purpose study was determine prevalence apparently "silent LUTS" (perceived asymptomatic LUTS) men a Ghanaian Community well its underlying risk factors.One hundred eleven (111) (40-70 years) were...
Background: Croton membranaceus extract has apoptotic effects on BPH-1 cells. This study determined if the were created through ceramide pathway. Methods: The was a follow-up to previous observational of 30 histologically confirmed patients with benign prostatic hyperplasia (BPH) who C. ethanolic at 20 mg t.i.d orally for 3 mo. Thereafter, total and free prostate-specific antigen (PSA), lipid profile plus Apo lipoprotein A B, ceramide/Sphingophospho-kinase 1 (SphK1) 2 (SphK2), sphingosine...