SCFA are produced in the gut by bacterial fermentation of undigested carbohydrates. Activation Gα i -protein-coupled receptor GPR41 β-cells and sympathetic ganglia inhibits insulin secretion increases outflow, respectively. A possible role stimulating leptin adipocytes is disputed. In present study, we investigated energy balance glucose homoeostasis knockout mice fed on a standard low-fat or high-fat diet. When diet, body fat mass was raised tolerance impaired male but not female compared...

Background The study was aimed at determining the effect of plasma chromium concentration on metabolism glucose, and lipids their subsequent cardiovascular risk in patients with type 2 diabetes Bolgatanga district Ghana. Material methods Fasting blood glucose profile were determined by enzymatic assay using BT 5000® Random Access Chemistry Analyzer. serum insulin High sensitive C-reactive protein ELISA, a solid phase direct sandwich immunoassay method. HOMA-IR, which is based fasting sample...

Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community George A Asare,1 Sheila Santa,1 Robert Ngala,2 Bernice Asiedu,1 Daniel Afriyie,3 Albert GB Amoah4 1Department Medical Laboratory Sciences, University Ghana School Allied Health Sciences (SAHS), Korle-bu, Ghana; 2Department Molecular Medicine, Kwame Nkrumah Science Technology, Kumasi, 3Department Pharmacology, 4Department School, Background: Hormonal (HCs) have been shown...

The etiology of benign prostatic hyperplasia (BPH) remains a mystery to scientists; estrogen/androgen imbalance in aged men has been implicated.Thirty (30) apparently healthy and newly diagnosed BPH patients were recruited from the Ghana Police Hospital. Lower urinary tract syndrome (LUTS) prostate volume assessed via symptom score sheet (IPSS) abdominopelvic scan, respectively. Laboratory assays for total specific antigen (tPSA) hormones [androstenedione (AED), testosterone (T),...

Background: The safety of combining tamsulosin (an allopathic drug) and Croton membranaceus aqueous extract, a medicinal plant for managing benign prostatic hyperplasia (BPH), was investigated. Methods: roots CM were used processed into water extract by maceration decoction. Thirty‐five Sprague Dawley rats divided seven groups five each. Groups 2–7 orchidectomy/testosterone injections BPH‐induced. Group 1 designated as the control group. 2 model group (untreated). 3 treated with 0.03 mg/kg...

Annona muricata L. has been reported to possess antitumor and antiproliferative properties. Not much work done on its effect BPH-1 cell lines, no in vivo studies targeting the prostate organ exist. The study determined of A human cells organ.The MTT assay was performed using aqueous leaf extract muricata. Cells (1 × 10(5) per well) were challenged with 0.5, 1.0, 1.5 mg/mL for 24, 48, 72 hours. Cell proliferation morphology examined microscopically. 10(4) seeded into 6-well plates incubated...

Gestational diabetes is a risk factor for perinatal complications; include shoulder dystocia, birth injuries such as bone fractures and nerve palsies. It associated with later development of type 2 diabetes, the macrosomia other long-term health effects infants born to diabetic mothers. The study assesses placental peptides maternal factors potential predictors gestational among pregnant women.A total 200 women were recruited study, 150 without pre including 50 low controls pregestational...

Leptin levels start increasing from the early stages of pregnancy, irrespective maternal body mass index. are increased in pregnant women with preeclampsia (PE) and may precede clinical onset disease, peaks occurring around 28 weeks gestation. This study was aimed at determining whether serum leptin concentration fat percentage significantly altered during first trimester pregnancies that subsequently develop PE such changes useful predicting disease.This a prospective longitudinal conducted...

This study was aimed at evaluating effect of Gestational diabetes mellitus (GDM) and maternal characteristics on pregnancy outcome. GDM has several risk factors including; advanced age, ethnic background, obesity family history mellitus. These complications are associated with fetal morbidity mortality may lead to macrosomia shoulder dystocia. Others stillbirth, miscarriages, preterm small for gestational age babies.This a retrospective case-case control which compared outcome among pregnant...

Picomolar concentrations of the beta3-adrenoceptor agonist BRL37344 stimulate 2-deoxyglucose uptake in soleus muscle via undefined receptors. Higher alter uptake, apparently beta2-adrenoceptors. Effects and beta2-adrenoceptor agonists are compared.Mouse muscles were incubated with 2-deoxy[1-(14)C]-glucose, [1-(14)C]-palmitate or [2-(14)C]-pyruvate, BRL37344, selective beta-adrenoceptor antagonists. Formation 2-deoxy[1-(14)C]-glucose-6-phosphate (14)CO2 was measured. 2-Deoxy[1-(14)C]-glucose...

In previous work, 10 pM BRL37344 and clenbuterol stimulated glucose uptake in mouse soleus muscle. Ten nM also but 100 inhibited uptake. Antagonist studies suggested that the opposite effects of are mediated by beta(2)-adrenoceptor. have been studied muscles lack beta(3)-, beta(2)- or all three beta-adrenoceptors. Effects beta-adrenoceptor antagonists on responses to agonists further using from wild-type mice.Soleus knockout mice were incubated with 2-deoxy[1-(14)C]-glucose, ligands....

We investigated how GW800644, the first pharmacologically selective murine peroxisome proliferator-activated receptor δ (PPARδ) agonist, affects energy balance, glucose homeostasis and fuel utilization by muscle in obese mice.Potencies were determined transactivation assays. Oral tolerance was after 14 22 days' administration (10 mg/kg body weight, twice daily) to Lep(ob)/Lep(ob) mice. Food intake expenditure measured during a 26-day experiment, plasma metabolites 2-deoxyglucose uptake vivo...

Benign prostatic hyperplasia (BPH) is an enlargement of the prostate. The study aimed at validating use freeze-dried Croton membranaceus ethanolic root extract for BPH management. Thirty-three patients were observed before and after 3-month administration 20 mg t.i.d orally. International Prostate Symptom Score (IPSS), Index Erectile Function (IIEF) questionnaires used. Total/free PSA (tPSA, fPSA), renal, liver function, lipid tests, ultrasonographic imaging performed. Thirty (30) (66 ± 11...

This study aimed at determining diabetes status of homeless people in Nima and Agbogbloshie, Accra, Ghana to evaluate the association between socio-demographic characteristics prevalence.A total 130 slum dwellers took part out which 7 (5.4%) participants were diagnosed with while 13 (10%) considered as having prediabetes. is slightly lower than what had been reported two decades ago but similar overall estimates prevalence Africa (5.7%). Diagnosis normoglycemia, prediabetes was based on...

WHO recommends HBV-negative babies in high-prevalence (8%) countries receive anti-HBV vaccination. Ghana initiated mass immunization 2002, but concerns remain about vaccine effectiveness and long-term protection. We evaluated immune characteristics factors following hepatitis B vaccination among Ghanaian adolescents who received HBV vaccines.

Abstract Background This study was aimed at determining the levels of serum adiponectin, leptin, resistin, visfatin and lipids during first trimester in pregnant women to evaluate relationship between these biochemical markers preeclampsia (PE). Available evidence point changes adipokines PE hence this examined potential using biomarkers prediction disease. Methods a case-control which compared anthropometric parameters who subsequently developed those did not. Blood pressure urine protein...

Free fatty acids have been reported to impair insulin action; Dietary fat composition has implicated in the development of resistance as well fasting glycaemia and type 2 diabetes mellitus. This work was designed determine benefits consuming vegetable oils on management diabetic mice. Forty eight (48) maledb/db mice were randomly divided into groups six. The first four fed chow (control), 10 % Red palm oil feed, groundnut coconut feed. second similar but addition administered glibenclamide...

Failure to achieve adequate glycemic control can lead debilitating complications for diabetics. Strict compliance prescribed diet, lifestyle, and medication prevent complications.In order examine factors accompanying noncompliance behavior diabetes in a rapidly urbanizing region of Ghana, mixed approach was adopted. Study subjects (N: 160, mean age: 58.3) were interviewed at the diabetic clinic Brong-Ahafo Regional Hospital, Sunyani. Compliance treatment evaluated with an adapted Morisky...

Kv1 channels are shaker-related potassium that influence insulin sensitivity. Kv1.3(-/-) mice protected from diet-induced resistance and some studies suggest Kv1.3 inhibitors provide similar protection. However, it is unclear whether blockade of in adipocytes or skeletal muscle increases glucose uptake. There no evidence the related channel Kv1.5 has any on sensitivity its expression adipose tissue not been reported. PAP-1 a selective inhibitor Kv1.3, with 23-fold, 32-fold 125-fold lower...

Calcium (Ca)- magnesium (Mg) imbalance is implicated in prostate cancer. Ca/Mg ratio increases or decreases with proliferation apoptosis, respectively. The study examined whether this exists BPH patients and the effect of a phytotherapeutic drug on ratio.Thirty (30) who used ethanolic root extract Croton membranaceus (60 mg/day) for 3 months were serum Ca, Mg, phosphate, parathyroid hormone (PTH), vitamin D, specific antigen (PSA) levels renal function tests (RFT) before (BT) after treatment...