A5055761012- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Tryptophan and brain disorders
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Birth, Development, and Health
- Advanced Chemical Sensor Technologies
- Coconut Research and Applications
- Sperm and Testicular Function
- Education and Technology Integration
- Cholesterol and Lipid Metabolism
- African Education and Politics
- Sphingolipid Metabolism and Signaling
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Traditional Chinese Medicine Studies
- Endoplasmic Reticulum Stress and Disease
- Cardiac Fibrosis and Remodeling
- Analytical Chemistry and Chromatography
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
Wake Forest University
2022-2023
Cleveland Clinic Lerner College of Medicine
2023
Atrium Health Wake Forest Baptist
2022
University of Surrey
2019-2021
Aston University
2021
Kwame Nkrumah University of Science and Technology
2016
Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They oxidation products may be differentially metabolised subcellular compartments biological fluids. New analytical methods needed to improve our understanding oxysterol trafficking the molecular interplay between cellular required maintain cholesterol/oxysterol homeostasis. Here we describe a method for isolation oxysterols using solid phase extraction quantification by liquid chromatography-mass...
Epidemiological studies show that higher circulating levels of odd chain saturated fatty acids (FA: C15:0 and C17:0) are associated with lower risk metabolic disease. These (OCSFA) produced by α-oxidation in peroxisomes, de novo lipogenesis, from the diet gut microbiota. Although present at low concentrations, they interest as potential targets to reduce disease risk. To determine whether OCSFA affected obesogenic diets, we have investigated high dietary fat intake affects frequency...
Free fatty acids have been reported to impair insulin action; Dietary fat composition has implicated in the development of resistance as well fasting glycaemia and type 2 diabetes mellitus. This work was designed determine benefits consuming vegetable oils on management diabetic mice. Forty eight (48) maledb/db mice were randomly divided into groups six. The first four fed chow (control), 10 % Red palm oil feed, groundnut coconut feed. second similar but addition administered glibenclamide...
The link between male diet and sperm quality has received significant investigation. However, the impact dietary supplements have on testicular environment been examined to a lesser extent. Here, we establish of sub-optimal low protein (LPD) morphology, apoptosis serum fatty acid profiles. Furthermore, define whether supplementing LPD with specific methyl donors abrogates any detrimental effects LPD. Male C57BL6 mice were fed either control normal (NPD; 18% protein; n = 8), an isocaloric...
Gas chromatography-coupled mass spectrometry (GC-MS) has been used in biomedical research to analyze volatile, non-polar, and polar metabolites a wide array of sample types. Despite advances technology, missing values are still common metabolomics datasets must be properly handled. We evaluated the performance ten commonly value imputation methods with analyzed on an HR GC-MS instrument. By introducing into complete (i.e., data without any values) National Institute Standards Technology...
Gas chromatography-coupled mass spectrometry (GC-MS) has been used in biomedical research to analyze volatile, non-polar, and polar metabolites a wide array of sample types. Despite advances technology, missing values are still common metabolomics datasets must be properly handled. We evaluated the performance ten commonly value imputation methods with analyzed on an HR GC-MS instrument. By introducing into complete (i.e., data without any values) NIST plasma dataset we demonstrate that...
Maternal obesity (MO) during pregnancy is linked to increased and premature risk of age-related metabolic diseases in the offspring. However, underlying molecular mechanisms still remain not fully understood. Using a well-established nonhuman primate model MO, we analyzed tissue biopsies plasma samples obtained from post-pubertal offspring (3-6.5 y) MO mothers (n = 19) control animals born fed standard diet (CON, n 13). All ate healthy chow after weaning. untargeted gas chromatography-mass...
Cardiovascular disease and heart failure are a major health challenge, with sex differences in pathophysiology treatment responses critically influencing patient outcomes. G protein-coupled receptor (GPCR) kinase 2 (GRK2) is pivotal regulator of cellular signaling whose elevation hallmark progression. Its complex network protein interactions impact wide range physiological pathophysiological processes including cardiac function. In this study, we examined the effects cardiac-restricted...
The study was carried out to assess the role of career development through Open and Distance Learning (ODL) on job performance basic school teachers in Kpando Municipal North Dayi Districts Ghana. target population includes all five hundred twenty two junior high eleven circuits area but using simple random sampling techniques, sixty drawn from four modes open distance learning (Sandwich, Dis- tance Learning, Evening/Part-Time Studies On-line/e-Learning) were selected. same technique also...
The liver is critical for functions that support metabolism, immunity, digestion, detoxification, and vitamin storage. Aging associated with severity poor prognosis of various diseases such as nonalcoholic fatty disease (NAFLD). Previous studies have used multi-omic approaches to study or examine the effects aging on liver. However, date, no an integrated omics approach investigate aging-associated molecular changes in livers healthy female nonhuman primates. goal this was identify baboons (
Abstract Nonalcoholic fatty liver disease (NAFLD) and Metabolic syndrome (MS) have become a global health concern as incidence of these metabolic disorders is growing rapidly in developing countries particularly the Middle East, South America Africa. Studies shown that protein restriction associated with increased risk diseases, possibly through effects on acid (FA) metabolism. In present study, we investigated whether low diet modulates FA metabolism methyl donor supplementation can...
Abstract The prefrontal cortex (PFC) has been implicated as a key brain region responsible for age-related cognitive decline. Little is known about aging-related molecular changes in PFC that may mediate these effects. To date, no studies have used untargeted discovery methods with integrated analyses to determine healthy female primates. We quantified associated aging baboons by integrating multiple omics data types (transcriptomics, proteomics, metabolomics) from samples across the adult...