A5102779890- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Alcohol Consumption and Health Effects
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Brucella: diagnosis, epidemiology, treatment
- Immune Cell Function and Interaction
- Eicosanoids and Hypertension Pharmacology
- Diabetes and associated disorders
- HIV Research and Treatment
- Hippo pathway signaling and YAP/TAZ
- Salmonella and Campylobacter epidemiology
- Cancer Immunotherapy and Biomarkers
- Botulinum Toxin and Related Neurological Disorders
- Deception detection and forensic psychology
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Anesthesia and Neurotoxicity Research
- Fatty Acid Research and Health
- Cancer Mechanisms and Therapy
- Burkholderia infections and melioidosis
- CRISPR and Genetic Engineering
- Anesthesia and Sedative Agents
Sahlgrenska University Hospital
2021-2025
University of Gothenburg
2021-2025
Zhejiang Normal University
2024-2025
First Affiliated Hospital of Nanchang University
2025
Alibaba Group (Cayman Islands)
2025
Nanchang University
2025
China University of Mining and Technology
2024
Indiana University School of Medicine
2020-2024
Indiana University – Purdue University Indianapolis
2020-2024
Ningbo University
2023
Objectives: Although systemic chemotherapy (SC) is the mainstay for treating unresectable intrahepatic cholangiocarcinoma (ICC), its efficacy limited and it causes severe side effects. This study focuses on evaluating effectiveness safety of hepatic arterial infusion (HAIC) in combination with lenvatinib plus programmed death-1 (PD-1) inhibitors (HLP), compared to SC PD-1 (SCLP) ICC. Methods: We analyzed patients initially diagnosed ICC at our center between March 2021 December 2023,...
<title>Abstract</title> The prevalence of steatotic liver disease (SLD) is rising globally, presenting a significant public health challenge. While non-contrast computed tomography (CT) scans hold promise for the opportunistic detection SLD, their full potential has not been systematically explored. Clinical indicators, such as serum data, are crucial monitoring progression SLD. We introduce novel Multimodal AI Opportunistic Steatotic Liver Disease Screening (MAOSS), which integrates...
Abstract Human mpox is a zoonotic disease, similar to smallpox, caused by the virus, which further subdivided into Congo Basin and West African clades with different pathogenicity. In this study, novel diagnostic protocol utilizing clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated 12a nuclease (CRISPR/Cas12a)‐mediated recombinase polymerase amplification (RPA) was developed identify in Africa (CRISPR‐RPA). Specific RPA primers targeting D14L ATI were...
Magnetite nanoparticles were coated with poly(propylene glycol) and β-cyclodextrin. Encapsulation of curcumin into the β-cyclodextrin functionalization folic acid afforded a targeted delivery system.
Background: NAFLD has become the leading cause of chronic liver disease worldwide afflicting about one quarter adult population. NASH is a severe subtype NAFLD, which in addition to hepatic steatosis connotes inflammation and hepatocyte ballooning. In light exponentially increasing prevalence it imperative gain better understanding its molecular pathogenesis. The aim this study was examine potential role STE20-type kinase TAOK1 —a hepatocellular lipid droplet-associated protein—in regulation...
Tuberculosis (TB) is a chronic infectious disease with high mortality caused by the Mycobacterium tuberculosis complex (MTC). Its clinical symptoms include prolonged cough mucus, pleuritic chest pain, hemoptysis, etc., and predominant complications such as tuberculous meningitis pleural effusion. Thus, developing rapid, ultrasensitive, highly specific detection techniques plays an important role in controlling TB. Here, we devised CRISPR/CRISPR-associated 12b nuclease (CRISPR/Cas12b)-based...
Alcoholic hepatitis (AH) is a severe inflammatory liver disease that develops in some heavy drinkers. The immune system patients with AH hyperactive and yet dysfunctional. Here, we investigated whether this immune‐dysregulated state related to the alcoholic impact on checkpoints (ICPs). We used multiplex immunoassays enzyme‐linked immunosorbent assay quantify plasma levels of 18 soluble ICPs (sICPs) from 81 AH, 65 drinkers without diseases (HDCs), 39 healthy controls (HCs) at baseline, 33 32...
Nonalcoholic fatty liver disease (NAFLD), defined by excessive lipid storage in hepatocytes, has recently emerged as a leading global cause of chronic disease. The aim this study was to examine the role STE20-type protein kinase TAOK3, which previously been shown associate with hepatic droplets, initiation and aggravation human NAFLD.The correlation between TAOK3 mRNA expression severity NAFLD investigated biopsies from 62 individuals. In immortalized intracellular fat deposition,...
The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD), affecting about 25% the global adult population. Non-alcoholic steatohepatitis (NASH) a severe form NAFLD characterized by lipid accumulation, inflammation, and hepatocyte ballooning, with different degree fibrosis. In light rapidly increasing prevalence NASH, there an urgent need for improved understanding molecular pathogenesis these diseases. aim this study was to decipher possible role STE20-type...
Introduction Brucellosis was made statutorily notifiable in 1955, China, while Guizhou Province, the pathogen of human brucellosis isolated for first time 2011. However, currently, epidemic is becoming more and severe Province. The type distribution genetic characteristics Brucella as well its evolutionary relationship with domestic foreign strains, are still unclear. Methods MLST, MLVA, rpoB typing techniques were used molecular epidemiological study 83 isolates province. Results Among MLST...
Abstract Hepatocellular carcinoma (HCC) is one of the most fatal and fastest growing malignancies. Recently, nonalcoholic steatohepatitis (NASH), characterized by liver steatosis, inflammation, cell injury (hepatocyte ballooning), different stages fibrosis, has emerged as a major catalyst for HCC. Because STE20‐type kinases, MST3 MST4, have been described critical molecular regulators NASH pathophysiology, we here focused on determining relevance these proteins in human By analyzing public...
Abstract Background The serum alanine aminotransferase (ALT) level is a critical parameter for evaluating liver injury in non‐alcoholic fatty disease (NAFLD). However, the currently accepted upper limits of normal (ULN) ALT (ULN‐ALT) are debated, as they may be excessively high. Methods A total 1638 children aged 6‐16 years, comprising 507 with BMI (500 healthy and 7 NAFLD), 199 overweight children, 932 obese were included analysis. We re‐evaluated ULN‐ALT 500 Chinese using 95th percentiles...
Hepatocellular carcinoma (HCC) is one of the most fatal and fastest-growing cancers. Recently, nonalcoholic steatohepatitis (NASH) has been recognized as a major catalyst for HCC. Thus, additional research critically needed to identify mechanisms involved in NASH-induced hepatocarcinogenesis, advance prevention treatment NASH-driven Because sterile 20-type kinase serine/threonine 25 (STK25) exacerbates NASH-related phenotypes, we investigated its role HCC development aggravation this study.
Alcoholic hepatitis (AH) is a severe inflammatory liver disease that develops in some heavy drinkers. AH patients have intense hepatic infiltration of leukocytes. Up-regulation cell adhesion molecules (CAMs) upon endothelial (EC) activation plays an important role leukocyte transendothelial migration. CAMs can shed from EC surface and accumulate the blood, serving as soluble markers for activation. In this study, we examined impact drinking on expression forms (CD146, ICAM-1, VCAM-1, VEGF-A)...
Heavy alcohol consumption disrupts gut epithelial integrity, leading to increased permeability of the gastrointestinal tract and subsequent translocation microbes. Regenerating islet-derived protein 3α (REG3α) Trefoil factor 3 (TFF3) are mainly secreted lumen by Paneth Goblet cells, respectively, functionally linked barrier integrity. Circulating levels REG3α TFF3 have been identified as biomarkers for damage in several human diseases. We examined whether plasma were dysregulated correlated...
Abstract Recent studies highlight the importance of lipotoxic damage in aortic cells as major pathogenetic contributor to atherosclerotic disease. Since STE20-type kinase STK25 has been shown exacerbate ectopic lipid storage and associated cell injury several metabolic organs, we here investigate its role main types vasculature. We depleted by small interfering RNA human endothelial smooth muscle exposed oleic acid oxidized LDL. In both types, silencing reduces accumulation suppresses...
Brucella abortus (B. abortus) as an important infectious agent of bovine brucellosis cannot be ignored, especially in countries/regions dominated by animal husbandry. Thus, the development ultrasensitive and highly specific identification technique is ideal strategy to control transmission brucellosis. In this report, a novel detection protocol, which utilizes multiple cross displacement amplification (MCDA) combined with gold nanoparticles-based lateral flow biosensor (AuNPs-LFB) targeting...