A5060709761- Pharmacogenetics and Drug Metabolism
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Malaria Research and Control
- Congenital Heart Disease Studies
- Pharmacological Effects of Natural Compounds
- Ethnobotanical and Medicinal Plants Studies
- COVID-19 epidemiological studies
- Berberine and alkaloids research
- Global Maternal and Child Health
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Gut microbiota and health
- Tissue Engineering and Regenerative Medicine
- Hepatitis C virus research
- Tracheal and airway disorders
- HIV/AIDS drug development and treatment
- Electrospun Nanofibers in Biomedical Applications
- HIV/AIDS Research and Interventions
- Bioinformatics and Genomic Networks
- HIV-related health complications and treatments
University of Cape Coast
2015-2024
University of Cape Town
2015-2023
International Centre for Genetic Engineering and Biotechnology
2020
Background: The functional interplay between tumor cells and their adjacent stroma has been suggested to play crucial roles in the initiation progression of tumors effectiveness chemotherapy. extracellular matrix (ECM), a complex network proteins, provides both physical chemicals cues necessary for cell proliferation, survival, migration. Understanding how ECM composition biomechanical properties affect cancer response chemotherapeutic drugs is vital development targeted treatments. Methods:...
The most accessible points of call for African populations with respect to primary health care are traditional systems that include spiritual, religious, and herbal medicine. This review focusses only on the use medicines. Most people accept medicines as generally safe no serious adverse effects. However, overlap between conventional medicine is a reality among countries in transition. Patients often simultaneously seek treatment from both same condition. Commonly encountered...
Mesenchymal stromal/stem cells (MSCs) represent an area being intensively researched for tissue engineering and regenerative medicine applications. MSCs may provide the opportunity to treat diseases injuries that currently have limited therapeutic options, as well enhance present strategies repair. The cellular environment has a significant role in development differentiation through cell–matrix interactions. aim of this study was investigate behavior adipose-derived (ad-MSCs) context...
Clinical oncology is in need of therapeutic innovation. New hypotheses and concepts for translation basic research to novel diagnostics therapeutics are called for. In this context, the cancer stem cell (CSC) hypothesis rests on premise that tumors comprise tumor cells a subset tumor-initiating cells, CSCs, quiescent state characterized by slow cycling expression specific surface markers with capability maintain vivo. The CSCs have unlimited self-renewal abilities propagate through division...
In sub-Saharan Africa, the reasons for low rates of COVID-19 vaccination and unwillingness to accept vaccine vary, so country-specific solutions are needed.1Lazarus JV Ratzan SC Palayew A et al.A global survey potential acceptance a vaccine.Nat Med. 2021; 27: 225-228Crossref PubMed Scopus (1075) Google Scholar Public health action that is humane, culturally relevant, recognises contribution historical, structural, other system dynamics has been called for.2Mutombo PN Fallah MP Munodawafa D...
Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature HAART administration. For populations in transition, dual use medicinal plant extracts and conventional medicine poses a significant challenge. There is need to evaluate interactions between commonly used drugs against HIV/AIDS. Efavirenz (EFV) nevirapine (NVP) major components both metabolized by CYP2B6, an...
This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on CYP450 enzyme activity. Recombinant fluorogenic substrates were used for evaluating inhibition, allowing assessment herb-drug interactions (HDI). Phytochemical fingerprinting was performed using UPLC-MS. The herbal risk ranked HDI based IC50 values determined each CYP enzyme. inhibited CYP1A2, CYP2C9, CYP2C19 activities with Ki 2.84 µg/mL, 1.55 1.23 respectively. N. exhibited a TDI (4.17) effect CYP1A2...
The tumour microenvironment plays a crucial role in progression and comprises stroma which is made up of different cell types the extracellular matrix (ECM). Mesenchymal stromal cells (MSCs) are part may have conflicting effects on growth. In this study we investigated effect Wharton’s Jelly‐derived MSCs (WJ‐MSCs) fibroblast‐derived ECM (fd‐ECM) esophageal (WHCO1) breast (MDA MB 231) cancer vitro . Both WJ‐MSCs fd‐ECM, alone or combination, downregulate PCNA, cyclin D1, Bcl‐2, Bcl‐xL, MMPs...
Researchers have long been presented with the challenge imposed by role of genetic heterogeneity in drug response. For many years, Pharmacogenomics and pharmacomicrobiomics has investigating influence an individual's background to response disposition. More recently, human gut microbiome proven play a crucial way patients respond different therapeutic drugs it shown that understanding composition microbiome, we can improve efficacy effectively identify targets. However, our knowledge on...
Background High-risk human papillomavirus HPV (HR-HPV) modifies cervical cancer risk in people living with HIV, yet African populations are under-represented. We aimed to compare the frequency, multiplicity and consanguinity of HR-HPVs HIV-negative HIV-positive Zimbabwean women. Methods This was a cross-sectional study consisting women histologically confirmed attending Parirenyatwa Group Hospitals Harare, Zimbabwe. Information on HIV status also collected for comparative analysis. Genomic...
Solid tumors display a complex biology that requires multipronged treatment strategy. Most anticancer interventions, including chemotherapy, are currently unable to prevent resistance and relapse. In general, therapeutics target cancer cells overlook the tumor microenvironment (TME) presence of stem (CSCs) with self-renewal tumorigenic abilities. CSCs have been postulated play key roles in initiation, progression, therapy resistance, metastasis. Hence, CSC markers suggested as diagnostics...
Despite great strides being achieved in improving cancer patients’ outcomes through better therapies and combinatorial treatment, several hurdles still remain due to therapy resistance, recurrence metastasis. Drug culminating relapse metastatic disease continue be associated with fatal disease. Cancer stem cells (CSCs) are a subpopulation of known resistant cause Whilst the debate on whether CSCs origins primary tumor rages on, have been further characterised many cancers data...