A5034601669- Mycobacterium research and diagnosis
- Antimicrobial Resistance in Staphylococcus
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Bacterial biofilms and quorum sensing
- Wound Healing and Treatments
- Systemic Sclerosis and Related Diseases
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antibiotic Resistance in Bacteria
- Burn Injury Management and Outcomes
- Legionella and Acanthamoeba research
- Antibiotic Use and Resistance
- Computational Drug Discovery Methods
- Pharmaceutical and Antibiotic Environmental Impacts
- Veterinary medicine and infectious diseases
- Humic Substances and Bio-Organic Studies
- Medical Research and Treatments
- Antimicrobial Peptides and Activities
- Fungal Infections and Studies
- Vasculitis and related conditions
- Cerebral Venous Sinus Thrombosis
- Synthesis and biological activity
Noguchi Memorial Institute for Medical Research
2014-2024
University of Ghana
2015-2024
University Medical Center Groningen
2015-2017
University of Groningen
2015-2017
ABSTRACT The spread of hypervirulent (hv) and carbapenem-/multidrug-resistant Klebsiella pneumoniae is an emerging problem in healthcare settings. New Delhi metallo-β-lactamase-1 ( bla NDM-1 ) found Enterobacteriaceae including K. pneumoniae. capable hydrolyzing β-lactam antibiotics which are used for treatment severe infections caused by multidrug-resistant Gram-negative bacteria. This associated with the unacceptably high mortality rate immunocompromised burn injury patients. study reports...
Efforts to control the spread of Buruli ulcer – an emerging ulcerative skin infection caused by Mycobacterium ulcerans - have been hampered our poor understanding reservoirs and transmission. To help address this issue, we compared whole genomes from 18 clinical M. isolates a 30km2 region within Asante Akim North District, Ashanti region, Ghana, with 15 other elsewhere in Ghana surrounding countries Ivory Coast, Togo, Benin Nigeria. Contrary expectations finding minor DNA sequence variations...
The reservoir and mode of transmission Mycobacterium ulcerans, the causative agent Buruli ulcer, still remain a mystery. It has been suggested that M. ulcerans persists with difficulty as free-living organism due to its natural fragility inability withstand exposure direct sunlight, thus probably within protective host environment.We investigated role amoebae by screening bacterium in (FLA) cultures isolated from environmental specimens using real-time PCR. We also followed survival...
Background In developing countries, hospitalized burn victims are at high risk of nosocomial infections caused by Staphylococcus aureus. Risk factors include poor infection control practices, prolonged hospitalisation and limited capacity for laboratory microbiological analyses. These problems compounded widespread use antibiotics that drives the spread multi-drug resistant bacteria. Methods During study period (November 2014-June 2015), nasal invasive S. aureus isolates were collected...
Background Buruli ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans. Previous studies have shown that wounds of BU patients are colonized with M. ulcerans and several other microorganisms, including Staphylococcus aureus, which may interfere wound healing. The present study was therefore aimed at investigating the diversity topography S. aureus colonizing during treatment. Methodology We investigated presence, diversity, spatio-temporal distribution in 30 confirmed...
Background Buruli ulcer (BU) is a skin infection caused by Mycobacterium ulcerans. The wounds of most BU patients are colonized with different microorganisms, including Staphylococcus aureus. Methodology This study investigated possible patient-to-patient transmission events S. aureus during wound care in health center. isolates from overlapping visits to the clinic were whole-genome sequenced and analyzed gene-by-gene approach using SeqSphere+ software. In addition, sequence data screened...
Buruli ulcer (BU) is a necrotizing infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. BU wounds may also be colonized with other microorganisms including Staphylococcus aureus. This study aimed to characterize virulence factors S. aureus isolated from patients. Previously sequenced genomes 21 isolates patients were screened for presence genes. The results show that all harbored on their core genes known like α-hemolysin, α- β-phenol soluble modulins. Besides...
Objectives: Staphylococcus aureus infections in burn patients can lead to serious complications and death. The frequency of S. infection is high low- middle-income countries presumably due limited resources, misuse antibiotics poor control. objective the present study was apply population genomics precisely define, for first time, transmission antibiotic resistant a resource-limited setting sub-Saharan Africa. Methods: surveillance performed amongst healthcare workers during seven-months...
Background: Antimicrobial resistance has rendered several anti-infective agents ineffective, necessitating the need to intensify efforts identify and develop novel drugs against microbial infection. Structural modification of existing antibiotics continues be one areas intense research focus in recent times. Objective: This study assessed antibacterial synergistic activity fifteen pyrazolyl sulphonamide derivatives Staphylococcus haemolyticus. Methods: Antibacterial was determined using...