A5072988639- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- Adolescent Sexual and Reproductive Health
- Dialysis and Renal Disease Management
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Kidney Disease and Diabetes
- Adolescent and Pediatric Healthcare
- Child Nutrition and Water Access
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Global Maternal and Child Health
- Malaria Research and Control
- Mosquito-borne diseases and control
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Impact on Reproduction
- Muscle and Compartmental Disorders
- Healthcare Systems and Reforms
- COVID-19 Clinical Research Studies
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
Kwame Nkrumah University of Science and Technology
2016-2025
Komfo Anokye Teaching Hospital
2016-2025
University of Ibadan
2024
Duke University
2024
University of Ilorin
2024
University of Nigeria
2024
Wake Forest University
2024
University of Florida
2017
Bernhard Nocht Institute for Tropical Medicine
2006
Kumasi Centre for Collaborative Research in Tropical Medicine
2006
Background. Equations for estimating glomerular filtration rate (GFR) have not been validated in Sub-Saharan African populations, and data on GFR are few. Methods. by creatinine clearance (Ccr) using 24-hour urine collections estimated (eGFR) the four-variable Modification of Diet Renal Disease (MDRD-4)[creatinine calibrated to isotope dilution mass spectrometry (IDMS) standard], Chronic Kidney Epidemiology Collaboration (CKD-EPI) Cockcroft–Gault equations were obtained Ghanaians aged 40–75....
Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function red blood cells-and risk for severe Plasmodium falciparum and its specific phenotypes, including cerebral malaria, anaemia, respiratory distress.
Peritoneal dialysis (PD) for acute kidney injury (AKI) in children has a long track record and shows similar outcomes when compared to extracorporeal therapies. It is still used extensively low resource settings as well some high regions especially Europe. In these regions, there particular interest the use of PD AKI post cardiac surgery neonates birthweight neonates. Here, we present update International Society Dialysis guidelines paediatrics. These review available literature updated...
Apolipoprotein L1 gene (
The target delivery channel of RTS,S candidate malaria vaccines in malaria-endemic countries Africa is the World Health Organisation Expanded Program on Immunization. As an Adjuvant System, age de-escalation and schedule selection step, this study assessed 3 schedules RTS,S/AS01(E) RTS,S/AS02(D) infants young children 5-17 months Ghana.A Phase II, partially-blind randomized controlled (blind to vaccine, not schedule), 19 duration was conducted two (2) centres Ghana between August 2006 May...
Background The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. formulated with the liposome based adjuvant AS01E or oil-in-water AS02D induces P. circumsporozoite (CSP) antigen-specific antibody and T cell responses which have been associated experimental challenge model adults. Methods This study was designed to evaluate safety immunogenicity induced over a 19 month period by...
In Sub-Saharan Africa, increasing numbers of children with perinatally acquired HIV (PAHIV) are living into adolescence. These adolescents face numerous unique challenges such as parent illness/death and years medication use. Optimizing care for these youth requires an understanding the factors that contribute to physical health, psychological well-being, social relationships, quality life (QOL). This mixed methods study collected quantitative questionnaire data from 40 Ghanaian PAHIV (50%...
Pharmacokinetic data on the first-line antituberculosis drugs using World Health Organization (WHO) revised dosages for children are limited. We investigated pharmacokinetics of these in who were mostly treated with dosages. Children tuberculosis therapy at least 4 weeks had blood samples collected predose, 1, 2, 4, and 8 hours postdose. Drug concentrations determined by validated liquid chromatography mass spectrometry methods, pharmacokinetic parameters calculated noncompartmental...
Although human immunodeficiency virus (HIV) coinfection is the most important risk factor for a poor antituberculosis (anti-TB) treatment response, its effect on pharmacokinetics of first-line drugs in children understudied. This study examined four anti-TB with TB and without HIV coinfection. Ghanaian isoniazid, rifampin, pyrazinamide, ethambutol at least 4 weeks had blood samples collected predose 1, 2, 4, 8 hours postdose. Drug concentrations were determined by validated liquid...
Malnutrition is a serious public health problem particularly in developing countries where it responsible for 54% of under 5s mortality. Anthropometric measurements are key tools the assessment nutritional status and diagnosis malnutrition. Height weight not routinely done most clinics hospitals Ghana. Children therefore miss opportunity accurate detection malnutrition.To determine prevalence wasting among children <5 years to document extent under-diagnosis.From June August 2004, aged >3...
The Human Immunodeficiency Virus (HIV) epidemic has adversely affected the nutritional status and mortality of children in Africa. This study assessed disease burden, predictive clinical features outcomes for with severe acute malnutrition (SAM) concomitant HIV infection. was a cross-sectional prospective SAM aged between 3 months 13 years admitted to rehabilitation unit (NRU) Komfo Anokye Teaching Hospital. Socio-demographic, anthropometric data were documented serostatus established 2...
The majority of HIV-infected children in sub-Saharan Africa have not been informed their HIV status. Caregivers are reluctant to disclose status because concern about the child's ability understand, parental sense guilt, and fear social rejection isolation. We hypothesized that low prevalence pediatric disclosure Ghana is due lack accurate information high stigma among caregivers. This a preliminary analysis baseline data an intervention study ("Sankofa"). "Sankofa" – two-arm randomized...
ABSTRACT Isoniazid and rifampin are essential components of first-line antituberculosis (anti-TB) therapy. Understanding the relationship between genetic factors pharmacokinetics these drugs could be useful in optimizing treatment outcomes, but this is understudied children. We investigated N-acetyltransferase type 2 ( NAT2 ) genotypes isoniazid pharmacokinetics, as well that solute carrier organic anion transporter family member 1B1 (encoded by SLCO1B1 carboxylesterase CES2 single...
Chronic kidney disease (CKD) is an important global health challenge with increasing burden worldwide. CKD and acute injury (AKI) may require renal replacement therapy (RRT) at some stages of the disease. Ghana currently has no transplant program. Dialysis services still remain a mirage to many chronic patients in due cost paucity hemodialysis machines. This survey highlights geographical distribution dialysis Ghana. A cross-sectional situational centers ten regions was conducted by...
Optimal doses for antituberculosis (anti-TB) drugs in children have yet to be established. In 2010, the World Health Organization (WHO) recommended revised dosages of first-line anti-TB children.
Developing sustainable treatment programs for kidney failure in most countries of sub-Saharan Africa continues to remain an imposing challenge. While long-term renal replacement therapies end-stage disease appear beyond national financial capabilities, there exist opportunities a short-term and affordable acute injury (AKI). Peritoneal dialysis (PD) is effective simpler modality compared hemodialysis (HD) can be performed without the need machinery or electricity, making it ideal choice...
Adherence to antiretroviral therapy (ART) remains one of the greatest obstacles in pediatric HIV care. We sought determine prevalence adherence ART among undisclosed HIV-infected children and adolescents Ghana. analyzed baseline data from aged 7-18 years old enrolled SANKOFA Pediatric disclosure intervention study Antiretroviral medication was measured using caregiver 3-day recall; child pharmacy records for time-to-refill. Four hundred twenty child-caregiver dyads were January 2013 June...