A5004323581- Inorganic and Organometallic Chemistry
- Malaria Research and Control
- HIV/AIDS drug development and treatment
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Sensors
- Computational Drug Discovery Methods
University of Health and Allied Sciences
2022-2024
Antimalarial resistance has hampered the effective treatment of malaria, a parasitic disease caused by Plasmodium species. As part our campaign on phenotypic screening phenylhydrazones, library six phenylhydrazones was reconstructed and evaluated for their in vitro antimalarial silico receptor binding pharmacokinetic properties. The structures phenylhydrazone hybrids were largely confirmed using nuclear magnetic resonance techniques. We identified two compounds which exhibited significant...
4-(2-(2,4-Dinitrophenyl) hydrazone) methyl)-2 methoxy phenol (IND-X) and 4-(2-(2, 4-dinitrophenylhydrazono) methyl) benzene-1,3-diol (IND-Y) were synthesised by condensation reactions with 2,4-dinitrinophenylhydrazine observed to possess acid-base indicator properties. The study was conducted explore verify their use in different analytical situations and, consequently, validate them. Analysis of titrations between strong acids/strong bases weak as well pharmaceutical applications the assay...