A5028474648- Synthesis and bioactivity of alkaloids
- Drug-Induced Hepatotoxicity and Protection
- Ethnobotanical and Medicinal Plants Studies
- Malaria Research and Control
- Traditional and Medicinal Uses of Annonaceae
- Complementary and Alternative Medicine Studies
- Synthesis and pharmacology of benzodiazepine derivatives
- Parasites and Host Interactions
- Berberine and alkaloids research
- Helminth infection and control
- Plant-derived Lignans Synthesis and Bioactivity
- X-ray Diffraction in Crystallography
- Moringa oleifera research and applications
- Parasite Biology and Host Interactions
- Essential Oils and Antimicrobial Activity
- Crystallization and Solubility Studies
- Synthesis and Reactivity of Heterocycles
- Insect Pest Control Strategies
- Pharmacogenetics and Drug Metabolism
- Signaling Pathways in Disease
- Computational Drug Discovery Methods
- Immune Response and Inflammation
- Toxoplasma gondii Research Studies
- Plant chemical constituents analysis
- Heavy Metal Exposure and Toxicity
Kwame Nkrumah University of Science and Technology
2016-2025
The therapeutic potential of stigmasterol, a natural steroid alcohol with established immune-modulatory properties, was assessed on allergic cutaneous responses. We examined its suppressive effect immunoglobulin E (IgE)-mediated active anaphylaxis (ACA), compound 48/80 (C48/80)-induced pruritus, and irritant dermatitis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Stigmasterol at 10-100 mg/kg significantly inhibited ACA reduction in reaction area concentration the extravasated Evans...
Cryptolepine (CPE) is the major indoloquinoline isolated from popular West African anti-malarial plant, Cryptolepis sanguinolenta. CPE possesses various pharmacological activities with potent activity against both chloroquine (CQ)-resistant and -sensitive strains. The search for safe novel agents combinations to delay resistance development Plasmodium falciparum directed this work aimed at evaluating interaction safety of in combination some artemisinin derivatives. vitro SYBR Green I,...
Discovery of novel gametocytocidal molecules is a major pharmacological strategy in the elimination and eradication malaria. The high patronage aqueous root extract popular West African anti-malarial plant Cryptolepis sanguinolenta (Periplocaceae) traditional hospital settings Ghana has directed this study investigating activity its alkaloid, cryptolepine. This also investigates interaction cryptolepine with standard anti-malarials, as search for new combinations continues.The...
Abstract Alpha-onocerin is a triterpenoid derived from Huperzia phlegmaria which used in ethnomedicine for the treatment of fever, headaches, pains and malaria. This study was conducted to evaluate safety, antipyretic anti-plasmodial activity alpha-onocerin artesunate (ART) co-administration ICR mice use traditional medicine. The effects (10, 30, 100, 300 mg/kg) ART (1, 2, 4, 8, 16 were assessed P. berghei -infected mice. /ART administered with fixed dose combination their median effective...
The emergence and resurgence of P. falciparum resistance to generations antimalarial drugs have prompted the search for new, effective, safe agents. This study aimed at investigating in vivo antiplasmodial activity 70% hydroethanolic extract constituents stem bark Myrianthus libericus based on its ethnomedicinal use as an agent. was assessed Swiss albino mice employing 4‐day suppressive Rane’s tests. MLB significantly ( p < 0.0001) suppressed parasitaemia by 52.26%, 65.40%, 77.11% 50,...
Tenofovir-based highly active antiretroviral therapy (HAART) is one of the preferred first-line therapies in management HIV 1 infection. Ghana has since 2014 adopted this recommendation; however there paucity scientific data that reflects safety and efficacy tenofovir-based compared to zidovudine Ghanaian health system. This study sought assess comparative immune reconstitution potential between tenofovir zidovudine-based HAART regimens, which includes lamivudine efavirenz combination...
Effective long-term management is the key to treatment of diabetes mellitus (DM) and its complications.To ascertain ability cryptolepine (CRP) in managing DM some associated complications.Changes fasting blood sugar (FBS), body weight, response thermally-induced pain, semen quality were assessed normal alloxan-induced diabetic rats treated with CRP (10, 30, or 100 mg/kg), glibenclamide (10 saline (2 ml/kg) per os. Hematological profile, liver kidney function tests, lipid as well liver,...
The prospect of eradicating malaria continues to be challenging in the face increasing parasite resistance antimalarial drugs so that novel antimalarials active against asexual, sexual, and liver-stage parasites are urgently needed. In addition, new need affordable available those most and, bearing mind climate change, should ideally sustainable. West African climbing shrub Cryptolepis sanguinolenta is used traditionally for treatment malaria; its principal alkaloid, cryptolepine (1), has...
This study focused on documenting and evaluating the cercaricidal activity of medicinal plants used for schistosomiasis treatment in an endemic area Ghana. Through semistructured questionnaires, personal interviews with herbalists communities surrounding Barekese dam Atwima-Nwabiagya district, where disease is endemic, were carried out. Thirty distributed 19 families reported to be survey. Information plants, including scientific names, common families, plant part recorded. The Apocynaceae...
Increasing resistance to current anti-malarial therapies requires a renewed effort in searching for alternative combat this challenge, and combination therapy is the preferred approach address this. The present study confirms anti-plasmodial effects of two compounds, cryptolepine xylopic acid relationship that exists their combined administration determined. Anti-plasmodial effect (CYP) (3, 10, 30 mg kg−1) (XA) was evaluated Plasmodium berghei-infected male mice after 6-day drug treatment....
This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites plasma urine after a single dose, evaluating single-dose oral intravenous pharmacokinetics male Sprague Dawley (SD) rats. The metabolic profiles were determined by LC-MS/MS following incubation with hepatocytes. vivo profile was samples from rats administration cryptolepine. Pharmacokinetic parameters administration. Nine identified resulting pathways involving...
Previous studies on cryptolepine, the antimalarial and cytotoxic alkaloid of Cryptolepis sanguinolenta, showed that it preferentially accumulates in rapidly proliferating cells melanin-containing tissues. Subsequently, we demonstrated cryptolepine was toxic to murine embryos vivo but no signs teratogenicity. developmental can be confounded by maternal effects. Here, hypothesized cryptolepine-induced embryo toxicity occurs at least partly through direct inhibition embryogenesis rather than...
The increasing mortality and morbidity of malaria in Africa coupled with the recent reports antimalarial drug resistance reinforces need for novel agents from natural plant products folkloric use disease. Murraya exotica (L.) (Rutaceae) is widely used as an ornamental indigenously to treat fever, cough, infectious wounds eliminate pain injury trauma. This study was conducted evaluate extracts leaves its safety antipyretic activity rodent models.In this study, Peters 4-day suppressive...
Justiciaflava (Acanthaceae) is utilized in folk medicine for treating malaria, inflammatory conditions, and respiratory infections. In this study, the antiplasmodial anti-inflammatory activities of 70% hydroalcoholic leaf extract J. flava (JFE) were investigated. The activity was assessed by suppressive test Rane’s curative test. carrageenan-induced paw oedema assay chicks used to assess activity. test, JFE significantly suppressed parasitaemia level ( <math...
The plant Terminalia ivorensis is used in traditional medicine as a diuretic and the management of renal failure. We reported previously that ethanol stem bark extract protects against gentamicin-induced hepatic damage rats. To further elucidate mechanism its renoprotective activity, we studied effects on Potassium dichromate–induced nephrotoxicity present study assessed effectiveness - oxidative injury evoked by potassium dichromate. Adult Sprague Dawley rats pre-treated with (100–1000...
Malaria is a serious infection affecting millions of people in Africa. Our study investigated the personal preferences and applications antimalarial medicines Ghana. Based on over 1000 questionnaires distributed Ghana from January to May 2019, we noticed that although Western medications fight this disease are widely available, most patients prefer treatment with locally produced herbal remedies. This preference appears be due combination traditional venues for obtaining “on street” rather...
The leaf of Theobroma cacao L. is used in traditional medicine Ghana for the treatment malaria, yet, with no scientific evidence its antimalarial property animals. It was, therefore, studied to validate Plasmodium berghei-infected mice. Infected mice were treated an aqueous extract T. at different doses 100, 200, and 400 mg/kg daily four days. Parasitaemia was determined before 24 hours following last dose extract. % reduction parasitaemia ED50 ED90 determined. Body weight, rectal...
Malaria is a serious infection affecting millions of people in Africa. Our study investigated the personal preferences and applications antimalarial medicines Ghana. Based on over 1000 questionnaires distributed Ghana from January to May 2019, we noticed that although Western medications fight this disease are widely available, most patients prefer treatment with locally produced herbal remedies. This preference appears be due combination traditional venues for obtaining “on street” rather...
Xylopic acid (XA), the major constituent of fruit
Malaria is a serious infection affecting millions of people in Africa. Our study investigated the personal preferences and applications antimalarial medicines Ghana. Based on over 1000 questionnaires distributed Ghana from January to May 2019, we noticed that although Western medications fight this disease are widely available, most patients prefer treatment with locally produced herbal remedies. This preference appears be due combination traditional venues for obtaining “on street” rather...
Aqueous root extract of Cryptolepis sanguinolenta has been used traditionally to treat many upper respiratory tract disorders. Besides its well-known broad spectrum antimicrobial activity, we had reasoned that cryptolepine can directly attenuate the symptoms asthma. Therefore, this study evaluates cryptolepine, main compound aqueous sanguinolenta, on early and late-phase asthma attack. In phase study, isolated was evaluated ability reverse histamine-induced bronchoconstriction reduce...