Most developing countries resort to medicinal plants for treating diseases, but few of these have scientific backing their use. The aim the study was validate traditional use Morinda lucida leaves in inflammation and determine mechanism action.Effect hydroethanolic leaf extract M. (HEML) on localized evaluated using rat paw edema presented by sub-planter injections λ-carrageenan, histamine or serotonin separate experiments. Systemic lipopolysaccharide (LPS)-induced hyperthermia. Antioxidant...

There is a growing need to develop new drugs for type II diabetes mellitus (DM) from plant sources due the high cost and adverse side effects of current drug therapies. To this end, antidiabetic activity aqueous stem-bark extract A. polycarpa (APE) in alloxan-induced diabetic ICR mice was investigated.The effect APE (20, 100 500 mg/kg), glibenclamide metformin as positive controls, were determined over 4 weeks on fasting blood glucose (FBG). An oral tolerance test (OGTT) also conducted. The...

Abstract Theobromine exerts deleterious effects on animal physiology. Removal of theobromine from the millions metric tons cocoa pod husks (CPH) discarded annually could allow for production cheap, CPH-based feed. The aim this study was to evaluate safety and nutritional value bio-detheobrominated CPH in Sprague–Dawley rats. removed by treatment with an isolate Talaromyces verruculosus (TvTD). Substituted feeds containing were formulated replacing 30% or 50% maize content regular rat feed...

In Ghana, the encapsulated blend of powdered stem and root bark Cassia sieberiana is prescribed dispensed to patients at Centre for Plant Medicine Research (CPMR), management dysmenorrhea gastric ulcer pain. This current formulation has significant challenges in manufacturing optimization therapeutic outcomes due lack standardization actual quantities extracts obtained from ingestion product. The study sought formulate evaluate capsules using bark. Extraction was undertaken with different...

Introduction: The root bark powder of the medicinal plant Capparis erythrocarpus is used at Centre for Plant Medicine Research (In Ghana) against inflammatory pain disorders. whole destroyed to obtain which constitutes only 11.1 % plant. Hence, going extinct. We therefore sought evaluate anti-inflammatory and analgesic activities bark, stem leaf C. in order explore them as substitute(s) agent bark. Methods: Carrageenan induced paw oedema assay was activity. Hot plate acetic acid writhing...

IJMBR is a highly brandable 5 letter .com name representing site about health and research. It served as an online platform for the International Journal of Medicine Biomedical Research, open-access journal meant to promote quality research publication in medical sciences.

Background: Scoparia dulcis is used in Ghanaian folkloric medicine for the management of asthma and its related complications. This study was therefore aimed at evaluating anti-tussive, muco-suppressant expectorant properties hydroethanolic extract S. (SDE), to ascertain safety use obstructive pulmonary disease management. Methods: The number coughs induced guinea pigs using citric acid concentration phenol red secreted tracheae mice were measured. Preliminary phytochemical analysis...

Mist Antiaris is a herbal decoction for treatment of nervous disorders. Safety and efficacy were evaluated in Sprague-Dawley rats human patients, respectively. Acute toxicity was assessed by administration single 5000 mg/kg oral dose to group six rats. For subchronic toxicity, four groups each received water (control) or 10, 100, 200 doses daily eight weeks. Body weight, serum, urine, hematological profile the animals monitored over period. Effects on pentobarbital-induced sleeping time...

Background. In Ghana, Cymbopogon citratus leaves together with guava, pawpaw, and lime are processed into a decoction to treat fever. To encourage its usage, preclinical validation of the safety profile plant is required. The acute subchronic toxicities conventional Soxhlet ethanolic extract in Sprague–Dawley rats were investigated. Methods. Pulverized extracted 98% ethanol using extraction (CSE) method dried. toxicity study, single dose 5000 mg/kg body weight was administered six female 1...

Abstract Background A hydro ethanol extract of the stem bark Holarrhena floribunda (HFE) has been shown to be effective in management acute inflammation. This study was evaluate usefulness for chronic inflammation a murine model. Methods Arthritis induced Sprague-Dawley rats using Complete Freund’s Adjuvant. Anti-arthritic effect evaluated prophylactic and therapeutic treatment models at doses 50, 200 500 mg/kg. Parameters assessed included oedema, serology inflammatory response, bone tissue...

Abstract Background : Holarrhena floribunda stem bark has anecdotal use in Ghanaian folk medicine for management of inflammatory conditions. This study was conducted to investigate the vivo anti-inflammatory activity extract using models acute inflammation male Sprague Dawley rats, C57BL/6 mice and 36 ICR mice. Methods A 70 % hydro-ethanol (HFE) evaluated at doses 5–500 mg/kg bw. Local anaphylaxis modelled by pinnal cutaneous anaphylactic test. Systemic or sepsis were modeled compound 48/80...

Knowledge, Attitude and Practice of Malaysian Public University Students on Risk Factors for Cardiovascular DiseasesMardhiah Mahada Ibrahim, Nor Azlina A. Rahman, Iza Mainul Haque

Background: Phyllanthus fraternus is a tropical plant that has numerous pharmacological activities such as blennorrhagia, colic, diabetes, dysentery, fever, flu, tumours, jaundice, vaginitis, dyspepsia, anti-inflammatory, antioxidant, anticoagulant, anti-diabetic, antiviral and analgesic. The study evaluated in vivo anti-plasmodial activity of aqueous ethanol crude extracts using Plasmodium berghei infected Balb/c mice.
 Methodology: preparation the extract was done by boiling 195 g...

Abstract Background Holarrhena floribunda (G.Don) T.Durand & Schinz stem bark has anecdotal use in Ghanaian folk medicine for the management of inflammatory conditions. This study was conducted to investigate vivo anti-inflammatory activity extract using models acute inflammation male Sprague Dawley rats, C57BL/6 mice and ICR mice. Methods A 70% hydro-ethanol (HFE) evaluated at doses 5–500 mg/kg bw. Local anaphylaxis modelled by pinnal cutaneous anaphylactic test. Systemic or sepsis were...

ABSTRACT Background and aim The lack of standardization scientific validation the use most plant extracts leads to toxicity problems. stem bark extract Annickia polycarpa has been shown possess antioxidant, antidiabetic, analgesic, anti-colitis effects. However, nothing is known about effects prolonged extract. Thus, we investigated acute sub-chronic aqueous (APE) in Sprague-Dawley rats. Experimental procedure LD50 APE (20 mg/kg, 100 500 mg/kg) was studied over 3 months Serum alkaline...

The present study was designed to investigate some biochemical parameters associated with acetaminophen induced liver injury on rats treated ethanolic stem-bark extract of Anacardium occidentale (EBAO). Qualitative studies EBAO showed the presence phytochemicals such as polyuronides, phenolic compounds and reducing sugars. Thirty (30) Wistar weighing 168.98 g 292.91 were grouped into five (I, II, III, IV V) six each. curative model applied. Liver Enzyme levels measured prior induction in...

Background: Pain is a major symptom usually associated with most disease states. Despite the existence of many therapies, management pain remains unsatisfactory globally. Medicinal plants have been used since medieval times and are still being today for treating some ailments. Desmodiumadscendens traditionally treatment epilepsy, pain, inflammatory conditions. However, data on its effect very scanty. Objective: This study sought to investigate antinociceptive an ethanolic extract...

Abstract Ethnopharmacological relevance In Ghanaian folk medicine, Holarrhena floribunda has anecdotal use for the treatment of inflammatory conditions. A hydro ethanol extract stem bark previously been shown to be effective in management acute inflammation and anaphylaxis rodents. Aim study This was aimed at evaluating usefulness H. (HFE) chronic a murine model. Materials Methods Anti-arthritic effect evaluated using Complete Freund’s Adjuvant-induced arthritis male Sprague-Dawley rats....