A5101484993- Microstructure and Mechanical Properties of Steels
- Algebraic structures and combinatorial models
- Advanced Algebra and Geometry
- Folate and B Vitamins Research
- Advanced Combinatorial Mathematics
- Magnetic Properties and Applications
- Metallurgy and Material Forming
- Advanced Topics in Algebra
- Microstructure and mechanical properties
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Epilepsy research and treatment
- Infectious Encephalopathies and Encephalitis
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Pancreatitis Pathology and Treatment
- Advanced Welding Techniques Analysis
- Metal Alloys Wear and Properties
- Airway Management and Intubation Techniques
- Barrier Structure and Function Studies
- Insect and Pesticide Research
- Animal Disease Management and Epidemiology
- Insects and Parasite Interactions
Nagoya University
1998-2025
Kobe University
2025
Hyogo Ion Beam Medical Center
2024
Okazaki City Hospital
2023-2024
Chiba Rosai Hospital
2014-2023
Tokai University
2020-2021
Okayama University
2009-2021
Suzuki (Japan)
2020
Anjo Kosei Hospital
2020
Kumamoto Medical Center
2020
The B cell inhibitory receptor FcγRIIB plays crucial roles in the maintenance of self-tolerance. We have identified a polymorphism FCGR2B c.695T>C that results non-conservative replacement 232Ile at transmembrane helix to Thr and demonstrated association with susceptibility systemic lupus erythematosus (SLE) Asians. In this study, we examined impact on functional properties by expressing each allele product human line ST486 lacking endogenous FcγRIIB. 232Thr was found be significantly less...
Environmental exposures and/or genetic background in Japanese population, which might contribute to the relatively low breast cancer incidence rates Japan, have not been clarified detail. Folate plays an essential role DNA methylation and synthesis, thus may be involved development of cancer. Functional polymorphisms genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), (MTRR A66G) thymidylate (TS), influence folate...
BACKGROUND: In Japan, the incidence rate of colon cancer has more rapidly increased than that rectal cancer. The differential secular trends may be due to different dietary factors in development and cancers.METHODS: To compare risk between cancers, we undertook a casecontrol study at Aichi Cancer Center Hospital, Japan. Subjects were 507 patients with newly diagnosed (n = 265) 242) 2,535 cancer-free outpatients (controls). Intakes nutrients food groups assessed frequency questionnaire,...
The influence of the carbon content on secondary dendrite arm spacing has been examined. From cooling curves for various locations in end chilled ingot, local average rate during solidification is measured. It found that over range contents studied, 0.14∼0.88%C, spacing, S μ, cast steels independent but influenced only by rate, R°C/min. relationship steel S=710R−0.39. shown this also valid low alloy containing 1.17%Cr and 0.25%Mo.
One-carbon metabolism, in which folate plays an essential role, is involved DNA methylation and synthesis, suspected of impacting on colorectal carcinogenesis. Alcohol well recognized as a risk factor for cancer (CRC) interactions with one-carbon metabolism have also been suggested. Therefore, functional polymorphisms genes encoding members this pathway, MTHFR C677T A1298C (genes methylenetetrahydrofolate reductase), MTR A2756G (gene methionine synthase) TS thymidylate tandem repeats...
Alcohol consumption is a strong risk factor for squamous cell carcinoma of the head and neck (SCCHN). The genetic polymorphisms aldehyde dehydrogenase2 ( ALDH2 ) Glu487Lys alcohol dehydrogenase 2 ADH2 His47Arg, which have impact on metabolism, are common in Japanese population. To clarify significance these SCCHN carcinogenesis, we conducted matched case‐control study with 239 incident subjects 716 non‐cancer controls. Both Arg/Arg Glu/Lys were found to be independently associated increased...
There is substantial evidence that the decreased risk of lung cancer with high intake vegetables and fruits linked to folate as a specific nutrient. Functional polymorphisms in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T A1298C), methionine synthase (MTR A2756G), (MTRR A66G) thymidylate synthase, influence thus might be suspected impacting on risk. We therefore conducted case–control study 515 cases newly histologically diagnosed 1030 age-...
Folate takes part in two biological pathways involved DNA methylation and synthesis, a potential protective influence of this nutrient chemical against carcinogenicity has been recognized several sites, including the esophagus. Therefore, functional polymorphisms genes encoding folate metabolizing enzymes, MTHFR C677T MTR A2756G, might be suspected impacting on esophageal cancer risk. We therefore conducted matched case–control study 165 cases 495 non-cancer controls to clarify associations...
Abstract Alcohol intake is positively associated with the risk of upper aerodigestive tract (UAT) cancer. The genes that encode alcohol-metabolizing enzymes, primarily alcohol dehydrogenases (ADH) and aldehyde (ALDH), are polymorphic. In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) ADH1C (rs698 rs1693482), UAT cancer have been observed, despite strong linkage disequilibrium among them. Moreover, was significantly rs1573496 ADH7, not rs1984362 ADH4. However,...
Low consumption of vegetables and fruits, which leads to insufficient folate intake, is associated with increased risk several types cancer, including head neck squamous cell carcinoma (HNSCC). Functional polymorphisms in genes encoding one‐carbon metabolism enzymes, such as methylenetetrahydrofolate reductase ( MTHFR C677T A1298C), methionine synthase MTR A2756G), MTRR A66G) thymidylate TS ), influence thus might impact on HNSCC risk. We conducted a case‐control study 237 cases newly...
A recent whole-genome association study identified a strong between polymorphisms in the prostate stem cell antigen (PSCA) gene and stomach cancer risk. In this case-control study, we aimed to validate association, further explore environmental factors possibly interacting with PSCA 708 incident cases age-sex matched controls. The Helicobacter pylori infection was also examined. We found that rs2294008 rs2976392, which were strongly linked each other (D' = 1.00), significantly associated Per...
Abstract Effect of alcohol consumption on pancreatic cancer risk has been investigated in many studies, but results have inconsistent. We conducted a case-control study to assess the effect conjunction with polymorphisms one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), (MTRR A66G), and thymidylate (TS) variable number tandem repeat. A total 157 patients 785 age- sex- matched control subjects were genotyped for polymorphisms....
Effects of Si and Cr contents on bainite microstructure medium carbon steels have been examined in order to obtain important information for good strength–ductility balanced spring steel. Four practical steels, JIS-S55C, SUP9, SUP7 SUP12 were isothermally transformed at temperatures between 300°C 500°C after austenitized 1000°C. The was observed by means scanning electron microscopy transmission microscopy. While carbide formed from the early stage transformation S55C without Cr,...
Abstract Objective It is important to identify and save the normal parathyroid glands during head neck surgery because of their role in regulating blood calcium level, yet it often difficult localize surgery. Fluorescence‐guided parathyroidectomy patients with hyperparathyroidism has already proved useful. However, there are few reports fluorescence‐guided localization humans. We investigated utility thyroidectomy completed a spectral fluorescence analysis accumulation 5‐aminolevulinic acid...
Alcohol consumption is recognized as a potential risk factor for colorectal cancer (CRC).Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol 2 (ADH2) His47Arg, which have strong impact on metabolism, are common in Japanese population but their significance CRC carcinogenesis remains to be clarified detail.We, therefore, conducted matched case-control study with 257 incident cases 771 non-cancer controls at Aichi Cancer Center, including analysis of interactions...