A5114246531- Electrodeposition and Electroless Coatings
- Semiconductor materials and interfaces
- RNA Research and Splicing
- 3D IC and TSV technologies
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Gallbladder and Bile Duct Disorders
- Immune Cell Function and Interaction
- Gastrointestinal disorders and treatments
- Electronic Packaging and Soldering Technologies
- Drug Transport and Resistance Mechanisms
- T-cell and Retrovirus Studies
- Lung Cancer Treatments and Mutations
- Biochemical and Molecular Research
- Pediatric Hepatobiliary Diseases and Treatments
- Erythrocyte Function and Pathophysiology
- Organ Transplantation Techniques and Outcomes
- HIV/AIDS drug development and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Myeloid Leukemia Research
- PARP inhibition in cancer therapy
- Copper Interconnects and Reliability
Toyota Memorial Hospital
2022-2025
The University of Tokyo
1962-2024
Waseda University
1995-2019
Jiangsu Provincial Urban Planning and Design Institute
2019
Kogakuin University
2019
Tokyo University of Science
1999-2017
Takeda (Japan)
2000-2016
Takeda (United States)
2010-2015
Saitama Municipal Hospital
2014
Kansai University
2010-2013
PURPOSE: To determine the computed tomographic (CT) features of uneven fatty replacement pancreas and clarify their radiologic clinical importance. MATERIALS AND METHODS: CT scans from 80 patients with were reviewed. Uneven was classified into two types. In type 1, posterior aspect head spared intense replacement. 2, focal area around common bile duct (CBD) Each divided subgroups on basis whether body tail showed (type a = negative for replacement, b positive replacement). Findings...
Transport of dicarboxylates across the chloroplast envelope plays an important role in transferring carbon skeletons to nitrogen assimilation pathway and exporting reducing equivalent cytosol prevent photo-inhibition (the malate valve). It was previously shown that Arabidopsis plastidic 2-oxoglutarate/malate transporter (AtpOMT1) general dicarboxylate (AtpDCT1) play crucial roles at interface between metabolism. However, based on vitro transport properties recombinant transporters, it...
The first small-molecule CCR5 antagonist, TAK-779, could not be developed as an anti-human immunodeficiency virus type (anti-HIV-1) agent because of its poor oral bioavailability. TAK-652 is orally bioavailable TAK-779 derivative with potent anti-HIV-1 activity. inhibited the binding RANTES (regulated on activation, normal T-cell expressed and secreted), macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta to CCR5-expressing cells at nanomolar concentrations. also suppress monocyte...
We characterized three Arabidopsis genes, AtpOMT1, AtpDCT1 and AtpDCT2, localized on chromosome 5 homologous to spinach chloroplastic 2-oxoglutarate/malate transporter (OMT) gene. The yeast-expressed recombinant AtpOMT1 protein transported malate 2-oxoglutarate but not glutamate. By contrast, the glutamate at similar affinities in exchange for malate. These findings suggested that is OMT a general dicarboxylate (DCT). proteins could also transport oxaloacetate same binding sites...
TAK-652, a novel small-molecule chemokine receptor antagonist, is highly potent and selective inhibitor of CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) replication in vitro. Since TAK-652 orally bioavailable has favorable pharmacokinetic profiles humans, it considered promising candidate for an entry HIV-1. To investigate the resistance to peripheral blood mononuclear cells were infected with R5 HIV-1 primary isolate KK passaged presence escalating concentrations compound more...
Pentatricopeptide repeat (PPR) proteins are encoded by the nuclear genome as a large gene family in land plants. PPR play essential roles organelle-related functions, mostly RNA-processing steps plastids and mitochondria. In moss Physcomitrella patens, there is also family, but likely to be divergent from those of higher To investigate function plastid proteins, we have generated characterized protein disruptant P. patens. The PPR531-11-disrupted mosses displayed abnormal phenotypic...
The pollen coat is a surface component of grains required for fertilization. To study how the produced, we identified and characterized recessive conditional male-sterile Arabidopsis mutant, flaky pollen1-1 (fkp1-1), whose lack functional coats. FKP1 single-copy gene in genome encodes 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMG-CoA synthase), an enzyme mevalonate (MVA) pathway involved biosynthesis isoprenoids such as sterols. We found that fkp1-1 possesses T-DNA insertion 550 bp...
The addition of leucine induced activation p70 S6k in amino acid‐depleted H4IIE cells. Whereas the by was transient, complete acid stimulated more persistently. effect on sensitive to rapamycin, but less wortmannin. Using various acids and derivatives leucine, we found that chirality, structure four branched hydrocarbons, primary amine are required for ability stimulate , indicating structural requirement induce is very strict precise. In addition, some exhibited other acted as inhibitors...
A novel class of quinazolinone derivatives as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors has been discovered. Key to success was application a rational discovery strategy involving structure-based design, combinatorial chemistry, and classical SAR for improvement potency bioavailability. The new were shown bind the nicotinamide-ribose binding site (NI site) adenosine-ribose (AD NAD+.
Two classes of quinazolinone derivatives and quinoxaline were identified as potent selective poly(ADP-ribose) polymerase-1 2 (PARP-1) (PARP-2) inhibitors, respectively. In PARP enzyme assays using recombinant PARP-1 PARP-2, displayed relatively high selectivity for showed superior PARP-2. SBDD analysis via a combination X-ray structural study homology modeling suggested distinct interactions inhibitors with These findings provide new framework the design
Background: Predictors of the clinical characteristics pregnant women at risk peripartum cardiomyopathy (PPCM) remain unclear.
Hereditary 1,25-dihydroxyvitamin D [1,25-(OH)2D]-resistant rickets (HVDRR) is a rare disorder characterized by rickets, alopecia, hypocalcemia, secondary hyperparathyroidism, and normal or elevated serum levels. We describe patient with typical clinical characteristics of HVDRR, except that levels phosphorus were present coincident increased intact PTH. The was treated high dose calcium infusion after an ineffective treatment 1 alpha-hydroxyvitamin D3; as well PTH alkaline phosphatase...
Abstract Recruiting a new blood supply is rate-limiting step in tumor progression. In three-dimensional model of breast carcinogenesis, disorganized, proliferative transformed epithelial cells express significantly higher expression angiogenic genes compared with their polarized, growth-arrested nonmalignant counterparts. Elevated vascular endothelial growth factor (VEGF) secretion by malignant enhanced recruitment (EC) heterotypic cocultures. Significantly, phenotypic reversion via...
Novel thiazole derivatives were synthesized and evaluated as vascular adhesion protein-1 (VAP-1) inhibitors. Although we previously identified a compound (2) with potent VAP-1 inhibitory activity in rats, the human was relatively weak. Here, to improve of 2, first structure-activity relationships guanidine bioisosteres simple small molecules 1H-benzimidazol-2-amine (5) compared phenylguanidine (1). Based on structure 5, highly inhibitor (37b; IC50=0.019 μM, rat IC50=0.0051 μM). Orally...