A5069968116- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Augmented Reality Applications
- Peripheral Artery Disease Management
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Advanced Vision and Imaging
- Radiation Dose and Imaging
- Aortic aneurysm repair treatments
- Coronary Artery Anomalies
- Robotics and Sensor-Based Localization
- Atrial Fibrillation Management and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Kawasaki Disease and Coronary Complications
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Genetic factors in colorectal cancer
- Cardiac tumors and thrombi
- Tunneling and Rock Mechanics
Nagoya University
2000-2025
Himeji Medical Center
2022-2024
GTx (United States)
2024
Kurashiki Central Hospital
2011-2023
Kobe University
2007-2023
Hyogo Brain and Heart Center
2020-2023
Canon (Japan)
1996-2021
Kyoto Prefectural University of Medicine
2020
Hyogo Prefectural Nishinomiya Hospital
2020
Shiga Medical Center
2020
Abstract Disruption of circadian rhythms, daily oscillations in biological processes that are regulated by an endogenous clock, has been linked to tumorigenesis. Normal and malignant tissues often show asynchronies cell proliferation metabolic rhythms. Cancer chronotherapy takes time into account improve the therapy. However, alterations clock machinery genes have rarely reported human cancer. Herein, we BMAL1 gene, a core component is transcriptionally silenced promoter CpG island...
The success of vascularized bone grafts from the medial femoral condyle in various clinical applications has sparked renewed interest microvascular anatomy this region. This study describes arterial supply distal and its implications harvesting grafts. location, branching pattern, internal diameter, distribution perforators descending genicular artery superior 19 fresh cadaveric lower limbs were recorded. was present 89% 100% specimens with average distances proximal to articular surface...
Background— We have noted abnormal angiographic findings—at the sites of drug-eluting stent implantation, suggesting contrast staining outside struts—that do not fulfill classic definition coronary artery aneurysm. propose a new term, peri-stent (PSS), for these findings and assess their incidence, risk factors, clinical sequelae. Methods Results— Peri-stent was defined as contour extending to ≥20% diameter. The study population consisted 3081 lesions (1998 patients) that were treated...
Mixed reality (MR) is a kind of virtual (VR) but broader concept than augmented (AR), which augments the real world with synthetic electronic data. On opposite side, there term, virtuality (AV), enhances or environment (VE) data from world. covers continuum AR to AV. This embraces definition MR stated by Milgram and Kishino (1994). We describe some technical achievements we made in Reality Project Japan.
Introduces a collaborative augmented reality (AR) system for real-time interactive operations. AR enables us to enhance physical space with computer-generated virtual space. In addition, allows multiple participants simultaneously share the surrounding them and that is visually registered one. They can also communicate each other through mixed This paper describes AR/sup 2/Hockey (Augmented Reality AiR Hockey) system, where players game field mallets, puck play an air-hockey game, as case...
This paper presents a new method of rendering for interaction with 3D virtual space the use gaze detection devices. In this method, hierarchical geometric models graphic objects are constructed prior to process. The process first calculates visual acuity, which represents importance object human operator, from position operator. Second, selects level set hierachical depending on value acuity. That is, simpler detail is selected where acuity lower, and more complicated used it higher. Then,...
In 141 mastectomy specimens, performed for invasive or noninvasive carcinomas, histopathologic study was to assess the extent of nipple-areola involvement by tumor. this study, patients were excluded if (1) tumor located beneath areola; and (2) nipple and/or areola abnormalities clinically present. Tumor found in 44 specimens (31%), with intraductal growth 36 (82%) 44, stromal invasion 3 (7%), ductal 5 (11%). Analysis nipple-areolar consideration different variables indicates that it...
Many tumor types including that of the ovary show loss heterozygosity (LOH) on chromosome arm 7q, which suggests existence at least one suppressor gene (TSG) this arm. We have studied region surrounding putative CUTL1 7q22 in 127 epithelial ovarian tumors. LOH was found across 31% malignant and 14% benign In 16% tumors appeared to be centered gene. This has been implicated previously as a TSG both uterine leiomyomas breast carcinoma. However, mutation analysis 47 with failed identify any...
Ror2, a member of the mammalian Ror family receptor tyrosine kinases, plays important roles in developmental morphogenesis, although mechanism underlying activation Ror2 remains largely elusive. We show that when expressed cells, associates with casein kinase Iϵ (CKIϵ), crucial regulator Wnt signaling. This association occurs primarily via cytoplasmic C-terminal proline-rich domain Ror2. also is phosphorylated by CKIϵ on serine/threonine residues, its serine/threonine-rich 2 domain,...
The receptor tyrosine kinase Ror2 plays important roles in mediating non‐canonical Wnt5a signaling by activating the Wnt–JNK pathway and inhibiting β‐catenin–TCF pathway. It has been shown that is phosphorylated activated casein Iɛ when both molecules are over‐expressed cultured cells. However, it remains unknown whether or not upon stimulation. Here we show on serine/threonine residues stimulation of cells, expressing endogenously, with Wnt5a, but Wnt3a. was found treatment cells glycogen...
Inherited retinal diseases (IRDs) comprise a phenotypically and genetically heterogeneous group of ocular disorders that cause visual loss via progressive degeneration. Here, we report the genetic characterization 1210 IRD pedigrees enrolled through Japan Eye Genetic Consortium analyzed by whole exome sequencing. The most common phenotype was retinitis pigmentosa (RP, 43%), followed macular dystrophy/cone- or cone-rod dystrophy (MD/CORD, 13%). In total, 67 causal genes were identified in 37%...
A registration method for outdoor wearable AR systems is described. Our approach based on using a high precision gyroscope, which can measure 3DOF angle of head direction accurately, but with some drift error. We solved the problem vision-based compensation algorithm, tracks natural features in environment as landmarks from images captured by camera an HMD. The paper first describes detail method. Then, calibration orientation sensor proposed. Finally, results actual system, comparison error...
We have sometimes noted abnormal angiographic coronary dilatation, <50% of the reference vessel, at site sirolimus-eluting stent implantation, suggesting contrast staining outside struts and named this finding peri-stent (PSS). Little was known about optical coherence tomography findings lesions with PSS.Between May 2008 March 2010, we performed for 90 in-stent restenosis after implantation. found PSS in 20 by angiography. The differences findings, including incomplete apposition, multiple...
This paper introduces a new type of anthropomorphic agent that lives in 3D space where the real and virtual worlds are seamlessly merged. In this mixed reality (MR) space, people wearing see-through head-mounted display can interact with both physical objects time. MR an embodied conversational agent, named Welbo, is implemented to study how technology contributes. has several unique features, compared conventional desktop agent.
This paper describes a platform package, called MR Platform, which we have been implementing for research and development of augmented reality technology applications. package includes parallax-less stereo video see-through HMD software kit (SDK) Linux PC environment. The SDK is composed C++ class library making runtime applications related utilities such as camera calibration tool. By using the SDK, following functions are available: capturing video, handling six degree-of-freedom (DOF)...
<i>Purpose:</i> We aimed to evaluate the effects of photodynamic therapy (PDT) on different phenotypes age-related macular degenerations (AMD): typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV). <i>Procedures:</i> 246 eyes from 242 patients (tAMD: 139, PCV: 107 eyes) were recruited. Gender, age, best-corrected visual acuity (BCVA) before treatment, greatest linear dimension lesion phenotype PDT frequency evaluated for predicting BCVA at 12 months after...
Abstract Background Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate impact of CD14 ++ CD16 + monocytes on as assessed by virtual histology intravascular ultrasound (VH-IVUS), well their relationship fluctuating levels in patients with asymptomatic artery disease (CAD). Methods Fifty-one CAD, who were undergoing lipid-lowering therapy and underwent VH-IVUS...