A5002672282- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Proteoglycans and glycosaminoglycans research
- Neuroscience and Neuropharmacology Research
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Ocular Disorders and Treatments
- Glioma Diagnosis and Treatment
- Kruppel-like factors research
- Systemic Lupus Erythematosus Research
- Hematological disorders and diagnostics
- Ocular Infections and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Connective tissue disorders research
- Anesthesia and Neurotoxicity Research
- Cerebral Venous Sinus Thrombosis
Minamiaoyama Eye Clinic
2018-2020
Kumamoto University
2008-2019
University of Miami
2018
Stem Cell Institute
2017
Saga University
2003-2013
Health Sciences University of Hokkaido
1999
Significance The lack of intravital imaging axonal transport mitochondria in the living mammalian CNS precludes characterization dynamics diseased and aged CNS. Here we report minimally invasive multiphoton mouse retinal ganglion cells that offers sequential time-lapse images transported a single axon with submicrometer resolution. We show highly dynamic vivo under physiological conditions characterize disturbances mitochondrial glaucoma model age-related changes transport. Our method is...
To elucidate the long-term outcomes and prognostic factors for trabeculectomy with mitomycin C (MMC) in eyes uveitic glaucoma (UG).A retrospective, consecutive, comparative cohort study was conducted 204 patients who underwent MMC between 1999 2008 at 2 Japanese clinical centers. The group included 101 UG 103 primary open-angle (POAG). Surgical failure defined as intraocular pressure levels of ≥21 mm Hg or an additional surgery. Kaplan-Meier survival curves surgical were compared POAG eyes,...
Neurons in the adult mammalian CNS decrease intrinsic axon growth capacity during development concert with changes Krüppel-like transcription factors (KLFs). KLFs regulate neurons including retinal ganglion cells (RGCs). Here, we found that knock-down of KLF9, an suppressor is normally upregulated 250-fold RGC development, promotes long-distance optic nerve regeneration rats both sexes. We identified a novel binding partner, MAPK10/JNK3 kinase, and JNK3 (c-Jun N-terminal kinase 3) critical...
Purpose To analyze the effects of factors on aqueous humor proinflammatory cytokine and growth factor levels in patients with uveitic glaucoma (UG). Methods In this cross-sectional study, we enrolled 143 participants: 1) UG (n = 39); 2) primary open-angle (POAG) 36); 3) cataract surgery patients, as a comparative group 68). Aqueous samples were obtained at start surgery. determined using multiplex immunoassay (xMAP Human Cytokine/Chemokine Panel I). Results cases, mean interleukin (IL)-6,...
To evaluate the effects of intravitreal bevacizumab (IVB) before mitomycin C trabeculectomy (MMCT) for neovascular glaucoma (NVG).The study is a retrospective, comparative, consecutive case series. The group consisted 57 eyes from 50 patients with NVG who underwent first MMCT: 33 were treated MMCT alone between June 1, 2005 and May 17, 2007 (Control Group); and, 24 combination IVB after 18, (IVB Group). Surgical complications, intraocular pressure (IOP), probability success compared 2...
Purpose: Adult central nervous system (CNS) neurons are unable to regenerate their axons after injury. Krüppel-like transcription factor (KLF) family members regulate intrinsic axon growth ability in vitro and vivo, but mechanisms downstream of these factors not known. Methods: Purified retinal ganglion cells (RGCs) were transduced express exogenous KLF9, KLF16, KLF7, or KLF11; microarray analysis was used identify genes, which screened for effects on growth. Dual-specificity phosphatase 14...
Whether pseudophakic eyes are resistant to trabeculectomy remains unknown.To determine the effect of previous phacoemulsification on surgical success with mitomycin C for open-angle glaucoma.Prospective clinical cohort study at Kumamoto University Hospital, Kumamoto, Japan, among patients 55 years or older having glaucoma intraocular pressure (IOP) 22 mm Hg higher, including 39 phakic (phakic group) and 25 after (pseudophakic group).Trabeculectomy was performed.The primary outcome measure...
Purpose.: To investigate aqueous humor proinflammatory cytokine levels of patients with neovascular glaucoma (NVG), and to analyze the effects background factors in expression these molecules. Methods.: This cross-sectional study enrolled 137 participants who were grouped into (1) primary open-angle (POAG; n = 36) patients; (2) NVG (NVG; 33); (3) cataract surgery as a comparative group (CG; 68). Aqueous samples collected from anterior chamber at start surgery, deposited CryoTubes,...
To evaluate the efficacy and safety of ripasudil for treatment secondary glaucoma, a historical cohort study was conducted at 18 centres in Japan. Adults (age ≥20 years) who needed additional IOP reduction received topical 0.4% between 2014 2018 due to three glaucoma subtypes, including uveitic (UG), exfoliation (EG) or steroid-induced (SG) were assessed mean change from baseline prior with ripasudil. We further evaluated each subtype, characteristics cohort, course uveitis-induced...
Purpose This study investigated the effects of posterior sub-Tenon capsule (PST) injection triamcinolone acetonide (TA) on intraocular pressure (IOP) in human eye. Methods The included 115 patients who received PST injections 40-mg TA to treat macular edema with diabetic retinopathy (n=57), branch retinal vein occlusion (n=35), central (n=13), or other disorders (n=10). IOP measurements were performed day injection, and 0.5, 1, 2, 3, 6, 9, 12 months later. Results In 26 (22.6%) eyes, an 24...
During human embryogenesis, neural crest cells migrate to the anterior chamber of eye and then differentiate into inner layers cornea, iridocorneal angle, portion iris. When proper development does not occur, this causes angle dysgenesis intraocular pressure (IOP) elevation, which ultimately results in developmental glaucoma. Here, we show that heparan sulfate (HS) deficiency mouse dysgenesis, including corneal endothelium defects, stroma hypoplasia, dysgenesis. These dysfunctions are...
PURPOSE. Heparan sulfate (HS) is abundantly expressed in the developing neural retina; however, its role intraretinal axon guidance of retinal ganglion cells (RGCs) remains unclear. In this study, authors examined whether HS was essential for RGCs toward optic nerve head. METHODS. The conditionally ablated gene encoding exostosin-1 (Ext1) enzyme, using dickkopf homolog 3 (Dkk3)-Cre transgene, which disrupted expression mouse retina during directed pathfinding by RGC axons situ hybridization,...
The epigenetic mechanisms associated with ocular neurodegenerative diseases remain unclear. present study aimed to determine the role of lysine-specific demethylase 1 (LSD1), which represses transcription by removing methyl group from methylated lysine 4 histone H3, in retinal ganglion cell (RGC) survival, and investigate details neuroprotective mechanism tranylcypromine, a major LSD1 inhibitor.The authors evaluated whether tranylcypromine contributes neuronal survival following...
Purpose.: Disruption of the axonal transport neurotrophic factors plays a critical role in apoptosis retinal ganglion cells (RGCs) glaucomatous optic neuropathy. Live-cell imaging vitro was used this study, to visualize and evaluate brain-derived factor (BDNF) both living axon-damaged RGCs. Methods.: Rat RGCs were purified by two-step immunopanning method. Cultivated transfected with plasmid encoding BDNF tagged green fluorescent protein (GFP), dynamics BDNF-GFP axons dendrites analyzed...
The objective of this study is to evaluate and compare the short-term efficacy safety Ex-PRESS® mini shunt surgery trabeculectomy for neovascular glaucoma (NVG). Patients with NVG who underwent or as a primary between March 2013 October 2015 were included in study, their medical charts retrospectively reviewed. groups 14 eyes 30 eyes, respectively. Surgical failure was defined by an intraocular pressure (IOP) ≥21 mmHg (condition A) ≥ 18 B); Kaplan–Meier survival analyses multivariable Cox...
To evaluate the influence of phacoemulsification after trabeculectomy on postoperative intraocular pressure (IOP) in eyes with uveitic glaucoma (UG).Kumamoto University Hospital, Kumamoto, Japan.A retrospective cohort study.The medical records patients UG who had mitomycin-C (MMC) were reviewed. Complete and qualified surgical failures defined by an IOP ≥21 mmHg (condition A), ≥18 B), or ≥15 C) without eye drops, respectively. Kaplan-Meier survival analysis, generalized Wilcoxon test, Cox...
Purpose To investigate the dependence upon intraocular pressure (IOP) of progression visual field defects in eyes with primary open-angle glaucoma (POAG), which mean IOP was maintained at ≤21 mm Hg. Methods This study involved 100 POAG, were followed up for ≥5 years. The levels Hg during follow-up period. relationship between and defects, scored using Advanced Glaucoma Intervention Study criteria, investigated retrospectively. Results Compared baseline scores, defect scores had significantly...
The object of this study is to investigate the effect early bleb parameters measured by three-dimensional anterior-segment optical coherence tomography on surgical success trabeculectomy.This retrospective included 45 patients with 19 exfoliation glaucoma, 17 primary open angle 4 neovascular uveitic glaucoma and 1 caused from familial amyloid polyneuropathy who underwent trabeculectomy. Bleb parameters, such as total height, position width filtration openings scleral flap, wall thickness,...
Purpose To evaluate the postoperative changes in blebs and levels of aqueous monocyte chemotactic protein-1 (MCP-1) after trabeculectomy vs. Ex-PRESS tube shunt surgery. Methods Rabbits were subjected to or surgery observed for up 3 months. Intraocular pressure (IOP) was measured using a rebound tonometer. The MCP-1 level by enzyme-linked immunosorbent assay (ELISA). Bleb morphology evaluated photos anterior-segment optical coherence tomography (OCT). Results There no differences bleb...
Objective To compare surgical outcomes between the first and second operated eyes in patients who underwent trabeculectomy both eyes. Methods This retrospective clinical cohort study at five centers Japan included 84 with open-angle glaucoma primary The outcome was success or failure, failure being defined according to three criteria: <20% reduction of preoperative intraocular pressure (IOP), Criterion A, IOP >21 mmHg; B, >18 C, >15 mmHg. Cases reoperation, a loss light perception vision,...