A5046102760- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Neuroscience and Neuropharmacology Research
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Ocular Oncology and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Ocular Surface and Contact Lens
- Protein Tyrosine Phosphatases
- Ophthalmology and Visual Impairment Studies
- 14-3-3 protein interactions
- Neurological Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Temporomandibular Joint Disorders
- Congenital heart defects research
- Nicotinic Acetylcholine Receptors Study
- Glycosylation and Glycoproteins Research
- Medicinal Plants and Neuroprotection
- Neurofibromatosis and Schwannoma Cases
- Axon Guidance and Neuronal Signaling
Hiroshima University
2016-2025
Seirei Hamamatsu General Hospital
2022
Weatherford College
2021
Takenaka (Japan)
2021
Précis: This study evaluated the 1-year efficacy and safety of a novel minimally invasive glaucoma surgery, gonio scratch, in reducing intraocular pressure eyes with open-angle cataracts. Purpose: To evaluate phacoemulsification cataract extraction combined scratch (GS-Phaco), patients Patients Methods: prospective multicenter clinical trial was conducted at Hiroshima University, Yokoyama Retina Clinic, Kusatsu Eye Miyoshi Clinic Japan. The primary outcome measure rate (IOP) control. Failure...
To evaluate the efficacy and safety of ripasudil for treatment secondary glaucoma, a historical cohort study was conducted at 18 centres in Japan. Adults (age ≥20 years) who needed additional IOP reduction received topical 0.4% between 2014 2018 due to three glaucoma subtypes, including uveitic (UG), exfoliation (EG) or steroid-induced (SG) were assessed mean change from baseline prior with ripasudil. We further evaluated each subtype, characteristics cohort, course uveitis-induced...
Scar formation is the most common cause for failure of glaucoma filtration surgery because increased fibroblast proliferation and activation. We have now examined effect Y‐27632, a Rho‐associated protein kinase (ROCK) inhibitor, on postsurgical scarring in human Tenon fibroblasts (HTFs). Collagen gel contraction assay was used to compare contractility activity Y‐27632 with several antiglaucoma drugs. Immunofluorescence western blotting were examine expression scar formation–related factors....
Abstract Glaucoma leads to irreversible blindness. Numerous anti-glaucoma eye drops have been developed. Unfortunately, many patients with glaucoma still suffer from progressive visual disorders. Recently, ripasudil hydrochloride hydrate, a selective Rho-associated protein kinase inhibitor, was launched for the treatment of glaucoma. However, adverse events, such as conjunctival hyperemia, are often noted in clinical trials using healthy subjects. Therefore, we investigated onset, offset,...
We compared surgical outcomes in patients with either primary open-angle glaucoma or exfoliation after undergoing combined phacoemulsification a 120° 180° incision during Schlemm’s canal microhook ab interno trabeculotomy (μLOT-Phaco). This retrospective comparative case series examined 52 μLOT-Phaco eyes that underwent surgery between September 2017 and December 2020. Surgical qualified success was defined as an intraocular pressure (IOP) of ≤20 mmHg, ≥20% IOP reduction IOP-lowering...
Purpose The aim of the study was to investigate effects various anatomical structures on intraocular pressure (IOP) measurements obtained by Corneal Visualization Scheimpflug Technology (Corvis ST), Goldmann applanation tonometer (GAT), and noncontact (NCT), as well assess interchangeability among four types IOP measurement: IOP-GAT, IOP-NCT, IOP-Corvis, biomechanically corrected (bIOP-Corvis), with a particular focus bIOP-Corvis. Materials methods We included 71 patients primary open-angle...
This study retrospectively examined the mid-term surgical outcomes between microhook ab interno trabeculotomy (μLOT) and goniotomy when one was using Kahook Dual Blade (KDB) in combination with phacoemulsification primary open-angle glaucoma exfoliation patients. Between December 2016 2020, current 47 μLOT 52 KDB eyes that underwent surgery. When there a < 20% reduction preoperative intraocular pressure (IOP) or IOP > 18 mmHg (criterion A), 14 B) at two consecutive follow-up visits,...
The purpose of this study was to investigate the role played by platelet-derived growth factor-α (PDGFRα) in oxidative stress-induced retinal cell death. A previous proteomic from our laboratory showed that expression PDGFRα is elevated considerably retinas an animal model glaucoma-the excitatory amino acid carrier (EAAC) 1-deficient (EAAC1-/-) mouse.Retinal sites and patterns were determined immunohistochemistry EAAC1-/- control CRL:CD1(ICR) mice. line exposed hydrogen peroxide, Western...
This study examined glaucoma patients after undergoing combined cataract and minimally invasive surgery (MIGS), microhook ab interno trabeculotomy goniotomy with the Kahook Dual Blade (KDB), or alone, it then evaluates their vision-related quality of life (VR-QOL) following procedure. A total 75 eyes consecutive in this prospective cohort underwent phacoemulsification (Phaco) phaco MIGS (Phaco-TLO) between October 2019 March 2022. In all cases, National Eye Institute Visual Function...
Purpose: The aim of this study was to evaluate ab interno trabeculotomy outcomes without phacoemulsification. Methods: This retrospective evaluated 118 eyes patients aged 18 and above who underwent between December 2017 August 2022. When surgeries were performed in both eyes, only the eye undergoing initial surgery evaluated. Prior after surgery, intraocular pressure (IOP) mean number IOP-lowering medications compared. An IOP ≤ 21 mmHg (A) (B) along with a ≥ 20% reduction preoperative...
Abstract Purpose To evaluate the fovea in nanophthalmic eyes using spectral domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA), to investigate relationship between macular microstructure visual acuity. Methods This is a retrospective case series of five patients. The foveal avascular zone (FAZ) area was measured superficial deep vascular layers with OCTA. thickness inner retinal layer (IRL) SD-OCT. ratio parafoveal IRL (fIRL/pIRL ratio) calculated. these parameters...
To investigate ciliochoroidal detachment (CCD) frequency and risk factors after performing microhook ab interno trabeculotomy (μLOT).A retrospective evaluation of 62 eyes patients who underwent μLOT were subsequently examined by anterior-segment optical coherence tomography (AS-OCT) found CCD at 1 day, 2 months surgery.In the (mean age 67.3 ± 13.9 years), AS-OCT detected in 18 (29%) day surgery, which disappeared within month. Comparisons between vs. non-CCD group showed mean IOPs 11.7 1.5...
There is no established method of maintaining or reducing intra ocular pressure after the needling procedure for failing blebs post trabeculectomy. Regarding newer antihypertensive medications, ripasudil, which a rho-associated protein kinase inhibitor ophthalmic solution, was able to prevent excessive scarring in vitro. This study aims evaluate safety glaucoma patients submitted and administered ripasudil preventing procedure. We also investigate efficacy bleb failure through suppression...
To examine primary open-angle glaucoma patients after undergoing combined cataract surgery with microhook ab interno trabeculotomy (μLOT-Phaco) or iStent inject W implantation (iStent-Phaco), and then evaluate the surgical outcomes a minimum of 6 months follow-up.Between October 2020 July 2022, 39 μLOT-Phaco eyes 55 iStent-Phaco that underwent were evaluated in this retrospective, multicenter comparative case series. Data included preoperative postoperative intraocular pressure (IOP), number...
We examined postoperative corneal higher-order aberrations (HOAs) present after combined phacoemulsification with either microhook ab interno trabeculotomy (μLOT-Phaco) or goniotomy, using the Kahook Dual Blade (KDB-Phaco). Retrospective study: A total of 45 eyes underwent μLOT-Phaco and KDB-Phaco (LOT-Phaco) procedures, 21 that cataract surgery alone used as controls. Visual acuity HOAs, coma-like aberrations, spherical-like were analyzed before at 1, 2, 3 months surgeries. Risk factors...
We evaluated glaucoma patients for the efficacy, safety and satisfaction associated with switching from brinzolamide 1% brimonidine 0.1% to a fixed combination of 0.1%. A total 22 were enrolled completed this prospective, nonrandomized study that who underwent treatment at least Patients on switched brinzolamide/brimonidine fixed-combination ophthalmic suspension (BBFC). Evaluations intraocular pressure (IOP), superficial punctate keratopathy (SPK) conjunctival hyperemia conducted baseline 4...
Glaucoma is optic neuropathy that characterized by progressive neurodegeneration of the retinal ganglion cells (RGCs) and axons. This condition will lead to visual impairment bring glaucoma become second cause blindness globally. Neuroprotection in needed prevent progression neuropathy. In this study, we examined effects superior colliculus (SC), mesencephalic astrocyte‐derived neurotrophic factor (MANF) secreted from SC, on RGC survival after oxidative stress. SC slices RGCs rats (3‐day...
Aim In patients who underwent multiple intraocular surgeries, we evaluated determinants of decreased corneal endothelial cell density (CECD) after sulcus placement following Ahmed and Baerveldt drainage device surgery. Methods We retrospectively reviewed consecutive with glaucoma an valve or a implant. compared presurgical postsurgical CECD risk factors for CECD. Results examined 41 eyes patients. Postsurgical measurements were assessed 2.0±1.0 times during median follow-up period 28 months....