A5085185208- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Optical Coherence Tomography Applications
- Corneal surgery and disorders
- Flavonoids in Medical Research
- Optical Polarization and Ellipsometry
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Photoacoustic and Ultrasonic Imaging
- Ocular Infections and Treatments
- Ocular and Laser Science Research
- Data Quality and Management
- Service-Oriented Architecture and Web Services
- Nicotinic Acetylcholine Receptors Study
- Corneal Surgery and Treatments
- Plant-based Medicinal Research
- Advanced Glycation End Products research
- Retinopathy of Prematurity Studies
- Retinal Development and Disorders
- Dermatologic Treatments and Research
- Saffron Plant Research Studies
- Protease and Inhibitor Mechanisms
- Scientific Computing and Data Management
- Retinoids in leukemia and cellular processes
- Neuroscience and Neuropharmacology Research
Tohoku University
2014-2024
Ophthalmology Associates (United States)
2018
Aqueous humor (AH) is one of the body fluids in eye, which known to be related with various ocular diseases, but complete RNAs characteristic AH patients not yet known. The aim this study was, a microarray analysis, reveal disease-related extracellular miRNAs profiles individual AH. 100 μl was collected by anterior chamber paracentesis from 10 glaucoma, 5 cataract and epiretinal membrane patients. extracted total were shorter than 200 nt their amount 5.27 ± 0.41 ng average. Among 530.5 44.6...
To analyze cytokine profiles of the aqueous humor eyes with primary open-angle glaucoma (POAG), neovascular (NVG), and cataract (as controls).A multiplex bead assay was used to measure concentrations 27 cytokines in samples from 54 eyes.Detection rates were as follows: IL-7: NVG higher than POAG; IL-10: POAG lower or NVG; GM-CSF: NVG. Concentrations IL-8, IP-10, MCP-1, MIP-1β: cataract; IL-9: IL-12: VEGF: cataract. Further analysis showed that MIP-1β correlated intraocular pressure age.The...
To evaluate the efficacy and safety of ripasudil for treatment secondary glaucoma, a historical cohort study was conducted at 18 centres in Japan. Adults (age ≥20 years) who needed additional IOP reduction received topical 0.4% between 2014 2018 due to three glaucoma subtypes, including uveitic (UG), exfoliation (EG) or steroid-induced (SG) were assessed mean change from baseline prior with ripasudil. We further evaluated each subtype, characteristics cohort, course uveitis-induced...
We demonstrate a prototype system of polarization-sensitive optical coherence tomography (PS-OCT) designed for clinical studies the anterior eye segment imaging. The can measure Jones matrices sample with depth-multiplexing two orthogonal incident polarizations and detection. An clock is generated using quadrature modulator logical circuit to double frequency. Systematic artifacts in measured are theoretically analyzed numerically compensated signals at surface sample. Local retardation...
Estimation of polarimetric parameters has been a fundamental issue to assess biological tissues that have form birefringence or polarization scrambling in polarization-sensitive optical coherence tomography (PS-OCT). We present mathematical framework provide maximum likelihood estimation the target covariance matrix and its incoherent decomposition estimate Jones dominant scattering mechanism, called Cloude-Pottier decomposition, thereby deriving phase retardation optic axis sample. In...
Purpose: To evaluate the relationship between skin autofluorescence (SAF), which reflects accumulation of advanced glycation end products (AGEs), and severity diabetic retinopathy (DR) in patients with type 2 diabetes.Methods: Sixty-seven eyes 67 diabetes were enrolled. age-matched non-diabetic subjects served as controls. Diabetic classified by their DR: no DR (NDR), non-proliferative (NPDR), proliferative (PDR). SAF was measured an reader.Results: significantly higher than controls (median...
The characteristics of glaucoma patients and their response to therapy may differ by institution, region country. Therefore, clinicians should understand the distinctiveness patients. Here, we profile primary open angle (POAG) normal tension (NTG) at a major university hospital in Japan. This study included 523 eyes from POAG NTG who underwent full clinical ophthalmologic evaluations Tohoku University Hospital. Clinical such as age, sex, visual acuity, intraocular pressure, Humphrey field...
This study investigated the effect of dipeptidyl peptidase-4 inhibitors (DPP-4is) on fibrosis after glaucoma filtering surgery with clinical data and an in vitro model that used transforming growth factor-β (TGF-β) to induce human Tenon's fibroblast (HTF) fibrosis.The medical records 41 eyes 35 patients diabetes neovascular (NVG) who received initial trabeculectomy were retrospectively reviewed. The surgical success rate was compared between cases (n = 23) did not receive 18) DPP-4i...
Abstract In glaucoma, although axonal injury drives retinal ganglion cell (RGC) death, little is known about the underlying pathomechanisms. To provide new mechanistic insights and identify biomarkers, we combined latest non-targeting metabolomics analyses to profile altered metabolites in mouse whole retina 2, 4, 7 days after optic nerve crush (NC). Ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry Fourier transform covering wide spectrum of...
Purpose: To determine whether anterior-segment optical coherence tomography (AS-OCT) can be used to predict post-trabeculectomy bleb outcomes.Materials and methods: We divided 58 eyes of 47 trabeculectomy patients into success or failure groups based on their status at 12 months after surgery. then compared various AS-OCT measurement parameters between the two 1 2 weeks 1, 3, 6, months. also analyzed early with multiple logistic regression, stepwise receiver operating characteristic (ROC)...
The aim of the study is to determine relationship between post-trabeculectomy bleb structure evaluated using anterior segment optical coherence tomography (AS-OCT) and postoperative intraocular pressure (IOP).Rretrospective showed for design this study.There are twenty-seven eyes 27 trabeculectomy patients.We drew contour lines cleft on 8-radius-scanned AS-OCT images, determined correlations measurements IOP at 6 months.The parameter used in an structure, including volume, wall brightness...
Background/Aims We determined the relationship between tissue mean blur rate (MT) and mitochondrial dysfunction, represented by mitochondrial/nuclear DNA (mtDNA/nDNA) ratio. also investigated usefulness of these biomarkers. Methods assessed ocular blood flow in 123 eyes patients with open-angle glaucoma (OAG) 37 control healthy subjects measuring MT optic nerve head laser speckle flowgraphy. measured mtDNA nDNA PCR, calculated mtDNA/nDNA ratio compared this using Spearman’s rank test. used...
To investigate the effect of plant-derived antioxidant compounds, identified with primary culture screening, on retinal ganglion cell (RGC) survival in mice under excitotoxic conditions. Additionally, to determine these compounds involvement calpain inactivation.Plant-derived including hesperidin, crocetin, and Tamarindus indica were administrated orally C57BL/6J mice. The levels lipid oxidation activation assessed a TBARS assay western blotting. RGC was evaluated TUNEL RBPMS immunostaining...
The aim of this study was to examine the effects oral administration kampo medical formulas on ocular blood flow (OBF). A crossover protocol used randomly administer five grams yokukansan, tokishakuyakusan (TSS), keishibukuryogan, or hachimijiogan 13 healthy blinded subjects (mean age: 37.3 ± 12.3 years). mean blur rate, a quantitative OBF index obtained with laser speckle flowgraphy, measured at optic nerve head before and 30 minutes after administration. Blood pressure (BP) intraocular...
Abstract Treatments for refractory glaucoma include trabeculectomy, in which a filtering bleb is created to reduce aqueous pressure. Mitomycin C (MMC) often used as an adjuvant post-trabeculectomy scarring and consequent failure. However, sometimes still occurs. Thus, we searched more effective trabeculectomy adjuvants with high-throughput screening (HTS) of library 1,165 off-patent drug compounds. This revealed that amsacrine (AMSA), DNA topoisomerase II (TOP2) inhibitor, was the top...
To determine the potential of anterior-segment optical coherence tomography (AS-OCT) to predict posttrabeculectomy outcomes in neovascular glaucoma (NVG).We recruited 45 eyes 40 NVG patients who underwent trabeculectomy. The were divided into success and failure groups based on outcome after 12 months. AS-OCT findings compared at 1 2 weeks 1, 3, 6, We also analyzed early bleb parameters with multiple logistic regression, stepwise receiver operating characteristic curve evaluate power these...
Purpose/Aim of the study Polarization-sensitive anterior-segmental optical coherence tomography (PS-OCT) is useful to evaluate filtering blebs after trabeculectomy. However, attenuation phenomenon OCT signal disturbs visibility intra-bleb’s structure and distribution birefringence; a specific parameter PS-OCT. This aimed effectiveness attenuation-coefficient image blebs.Materials methods included 25 eyes 6 months TLE. The was calculated from intensity information. contrast level...
Purpose To investigate the potential of colchicine to improve bleb function after trabeculectomy. Methods find maximum usable concentration, an ocular irritation study was performed with Draize test at concentrations 0.001%, 0.01% and 0.1%. Additionally, synergistic effect topical instillation MMC application surgical site evaluated in a rabbit model by measuring changes trabeculectomy intraocular pressure (IOP) morphology score 3, 7, 14, 21, 28, 35, 42, 49 days. Results Experiments showed...
In recent years, alternative monitoring approaches, such as risk-based and remote techniques, have been recommended instead of traditional on-site to achieve more efficient monitoring. Remote (R2BM) is a technique that combines focuses on the detection critical data process errors. Direct capture (DDC), which directly collects electronic source data, can facilitate R2BM by minimizing extent documents must be reviewed reducing additional workload R2BM. this study, we evaluated effectiveness...
PRéCIS:: Thinning of the macular retinal nerve fiber layer (mRNFL) and ganglion cell complex in papillomacular bundle area contributed significantly to visual acuity (VA) decline advanced glaucoma patients after trabeculectomy.To identify structural parameters that could predict VA trabeculectomy with open-angle glaucoma.Retrospective review 74 eyes (defined as mean deviation -12 dB or worse) best-corrected (BCVA) ≥40/200. All underwent between 2013 2016. Measurements included intraocular...
We assess long-term surgical outcomes after an initial trabeculectomy for cytomegalovirus-associated anterior uveitis with secondary glaucoma (CMV-SG).
Abstract Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including metabolites it contains, useful to understand physiological and pathological conditions eye. In current study, we used mass spectrometry (MS) characterize humor metabolomic profile biological features patients with glaucoma. Aqueous samples were collected during trabeculectomy surgery or cataract analyzed global metabolomics. We included 40 glaucoma (32 POAG, 8 NTG) 37 control...
Abstract Background Trabeculectomy (trab) is the most effective surgical procedure for lowering IOP and preventing glaucoma progression. However, decline in best-corrected visual acuity (BCVA) one of serious postoperative complications trab. Here, we investigated methods to predict decreased BCVA after trab patients with good preoperative BCVA. Methods This study included 35 eyes open-angle (OAG) (male / female: 21 14, age: 64.0 ± 9.7 years old, intraocular pressure: 15.9 5.4 mmHg, mean...