Purpose: To compare optic nerve head (ONH) blood flow in healthy eyes, eyes with preperimetric glaucoma (PPG), and mild normal-tension (NTG) using laser speckle flowgraphy (LSFG).Methods: In 172 (normal: 44 eyes; PPG: 62 NTG: 66 eyes), LSFG was used to measure mean blur rate the ONH tissue area (MBRT), an index of capillary flow. Multiple regression analysis performed determine factors affecting circumpapillary retinal fiber layer thickness (cpRNFLT), deviation (MD) pattern standard (PSD)...

We report a patient with neuromyelitis optica (NMO) presenting anti-myelin-oligodendrocyte glycoprotein (MOG)-seropositive, in whom biomarkers of demyelination and astrocyte damage were measured during an acute attack. A 31-year-old man developed right optic neuritis followed by longitudinally extensive transverse myelitis, fulfilling the criteria for definite NMO. He was anti-MOG-seropositive anti-aquaporin-4 seronegative. The myelin basic protein level markedly elevated whereas glial...

We tested the hypothesis that a questionnaire-based risk score predicts prevalence of patients with primary open-angle glaucoma (POAG) vascular predisposition. The Flammer Syndrome Questionnaire (FSQ) was used to determine scores in 823 healthy subjects and 512 POAG. Next, we characterized blood flow pulsatility changes within optic nerve head (ONH) syndrome (FS) using laser speckle flowgraphy (LSFG) 358 eyes 206 normal-tension (NTG). Last, examined association between Mean blur rate...

Our study was conducted to determine factors associated with the effectiveness of a β-blocker eye drop add-on in altering pulse rate (PR) glaucoma patients. This retrospective examined 236 eyes 138 patients who received during follow-up. Patients were included if at least one PR measurement available both before and after started. We collected data on ophthalmic parameters: longitudinal PR; choroidal blood flow, represented by laser speckle flowgraphy-measured mean blur (MBR);...

To compare glaucoma severity with ocular microcirculation, measured either laser speckle flowgraphy (LSFG) or optical coherence tomography angiography (OCTA).We retrospectively studied 82 eyes of open-angle (OAG) patients who underwent same-day LSFG and OCTA examinations, 20 healthy subjects as controls. In images, vessel density (VD) (%) was calculated in concentric regions (regions 1, 2 3: R1, R2 R3, respectively) defined by 1.6-, 3.2- 3.6-mm-diameter circles around the optic nerve head...

To investigate factors associated with choroidal microcirculation in the peripapillary chorioretinal atrophy (PPA) zone eyes normal-tension glaucoma (NTG) and myopic disc.In 100 of NTG patients disc 20 age-matched controls, 4.5 × mm scans were made optic nerve head optical coherence tomography angiography (OCTA). Peripapillary area PPA superficial image intensity (PPA-CI) calculated j software. Clinical characteristics, laser speckle flowgraphy-measured mean blur rate temporal tissue...

Purpose: To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods: This prospective study included 20 eyes of healthy volunteers. The testing protocol had a baseline phase, two IOP phases (+10 +20 mm Hg), recovery phase. was by pushing against eyelid with novel tubular device attached LSFG apparatus. Measurement parameters each phase included: LSFG-derived mean blur rate (MBR)...

Purpose: To investigate sectoral differences in the relationship between optic nerve head tissue blood flow, anatomically corresponding visual field defect severity, and future progression. Methods: This retrospective longitudinal medical chart review comprised 508 eyes of 319 open-angle glaucoma patients (mean deviation: −9.2 ± 7.0 dB), followed for an average 4.7 1.1 years; 11.7 3.7 tests were performed. Average total deviation (TD) was calculated superior, central, inferior sectors...

This study evaluated age-related changes in the superficial and deep retinal capillary plexus (SCP DCP, respectively) foveal avascular zone (FAZ). SCP DCP perfusion density (PD) were measured optical coherence tomography angiography (OCTA) macular scans of 145 eyes healthy Japanese subjects, findings compared with FAZ clinical data. We found that age was negatively correlated PD (r = -0.17, P 0.04 r -0.20, 0.02, positively area 0.18, 0.03). each other 0.67, < 0.001). PD, central thickness...

To assess the optic nerve head blood flow (ONH BF) response to hyperoxia in glaucoma patients using laser speckle flowgraphy (LSFG), and determine factors influencing vasoreactivity within ONH.We performed oxygen provocation testing 15 eyes of primary open-angle (POAG) age-matched control subjects. During test, LSFG-derived tissue mean blur rate (MBRT) clinical variables, including pressure, were recorded. We evaluated differences MBRT alteration during systemic between groups. Additionally,...

We aimed to assess the neuroprotective effect of a pyruvate dehydrogenase kinase (PDK) inhibitor, Nov3r after ischemia/reperfusion (IR) injury in rats. IR was induced by applying 150 mmHg intraocular pressure for 50 min. orally administered (100 mg/kg) 3 h before and 24 injury. TUNEL-positive cells increased immunoreactive RBPMS-positive decreased rat retinas Administration significantly ameliorated increase prevented cell decrease. Similarly, number IR-induced Iba1-positive microglial...

To investigate sectoral differences in the relationship between intraocular pressure (IOP) dynamics during dark-room prone testing (DRPT) and visual field (VF) defect progression primary open-angle glaucoma (POAG) patients. Retrospective, longitudinal study This retrospective included 116 eyes of 84 POAG patients who underwent DRPT had at least five reliable VF tests conducted over a more than two-year follow-up period. We excluded with mean deviation worse -20 dB or history surgery laser...

PurposeTo investigate clinical factors associated with foveal avascular zone (FAZ) parameters obtained using optical coherence tomography angiography (OCTA) assistance from a previously developed artificial intelligence (AI) platform in eyes open-angle glaucoma (OAG).DesignRetrospective, longitudinal.ParticipantsThis study followed up 885 of 558 OAG patients for at least 2 years; all underwent 5 Humphrey visual-field tests and had 3.0 x mm macular OCTA scans available.MethodsAverage total...

Abstract Purpose This study aimed to investigate differences in microvasculature dropout (MvD) between the superior and inferior hemispheres glaucoma patients. Study design Retrospective cross-sectional. Methods Fifty-eight eyes of 58 open-angle patients (age 61.12 ± 10.19 years, mean deviation − 7.32 6.36 dB) were included. MvD was detected with en face images from swept-source optical coherence tomography angiography. Blood flow at optic nerve head measured laser speckle flowgraphy,...

To compare blood flow (BF) impairment patterns in different optic neuropathies using laser speckle flowgraphy (LSFG).

Abstract Purpose To investigate the effect of optic nerve head (ONH) tissue vasoreactivity on glaucoma visual field defect progression. Methods This prospective, longitudinal study comprised 28 eyes 16 patients with open‐angle glaucoma. Baseline data were obtained from oxygen inhalation testing, including laser speckle flowgraphy measurements tissue‐area mean blur rate (MT), which represents ONH blood flow, and percentage change in MT (MT‐change). Follow‐up collected for at least 2 years, 5...

Abstract Background The dysfunction of optic nerve head (ONH) hemodynamics has been suggested to be involved in the pathogenesis normal-tension glaucoma (NTG). aim this study was compare vasoreactivity ONH, nailfold, and facial skin response cold-water provocation NTG patients healthy controls. Methods We performed 14 eyes 15 age-matched control subjects. Laser speckle flowgraphy-derived tissue-area mean blur rate (MT), blood flowmetry-derived pulse wave amplitude (PA), nailfold...