Noninvasive angiography is demonstrated for the in vivo human eye. Three-dimensional flow imaging has been performed with high-speed spectral-domain optical coherence tomography. Sample motion compensated by two algorithms. Axial between adjacent A-lines within one OCT image Doppler shift due to bulk sample motion. displacements neighboring images are a correlation-based algorithm. vasculature of ocular vessels visualized. By integrating volume sets images, two-dimensional blood obtained....

Retinal, choroidal and scleral imaging by using swept-source optical coherence tomography (SS-OCT) with a 1-μm band probe light, high-contrast three-dimensional (3D) of the vasculature are presented.This SS-OCT has measurement speed 28,000 A-lines/s, depth resolution 10.4 μm in tissue, sensitivity 99.3 dB.Owing to high penetration light system, vivo sclera healthy volunteer can be observed.A software-based algorithm scattering angiography (S-OCA) is developed for 3D vessels.The S-OCA used...

Phase retardation imaging including local birefringence of biological tissues is described by generalized Jones-matrix optical coherence tomography. The polarization properties a tissue can be obtained from two Jones matrices that are measured backscattered lights the front and back boundaries tissue. error in phase measurement due to background noise analyzed theoretically, numerically, experimentally. minimum detectable estimated numerical simulations. theoretical analysis suggests...

We present fiber-based polarization-sensitive swept-source optical coherence tomography (SS-OCT) based on continuous source polarization modulation.The light is a frequency swept laser centered at 1.31 μm with scanning rate of 20 kHz.The incident modulated by resonant electro-optic modulator 33.3 MHz, which one-third the data acquisition frequency.The zeroth-and first-order harmonic components OCT signals respect to modulation have polarimetric information sample.By algebraic and matrix...

Comprehensive angiography provides insight into the diagnosis of vascular-related diseases. However, complex microvascular networks unstable in vivo organs such as eye require micron-scale resolution three dimensions and a high sampling rate to access wide area maintaining resolution. Here, we introduce dual-beam-scan Doppler optical coherence (OCA) label-free comprehensive ophthalmic that satisfies theses requirements. In addition imaging speed, sensitivity motion for detecting tiny blood...

Phase retardation of in vivo human retinal nerve fiber layer (RNFL) is quantitatively measured by two methods—polarization-sensitive spectral-domain optical coherence tomography (PS-SD-OCT) and scanning laser polarimetry (SLP). An en face cumulative phase map calculated from the three-dimensional (3-D) volume healthy glaucomatous eyes PS-SD-OCT. It shown that curves around optic head PS-SD-OCT SLP have similar values except near blood vessels. can measure RNFL as well SLP, which will allow...

purpose. To evaluate the clinical significance of newly developed long-wavelength probe optical coherence tomography (LP-OCT) for diagnosis exudative macular diseases. methods. Fourteen eyes 13 participants were prospectively enrolled in study. There seven type I and five II choroidal neovascularization (CNV) cases associated with age-related degeneration idiopathic one case polypoidal vasculopathy (PCV). A custom-built LP-OCT based on swept-source OCT (SS-OCT) technology was used. This new...

We present a fiber based multifunctional Jones matrix swept source optical coherence tomography (SS-OCT) system for Doppler and polarization imaging. measurement without using active components such as electro-optic modulators is realized by incident multiplexing on independent delay of two orthogonal states diversity detection. In addition to sensitivity, this measures flow extra hardware phase stabilized SS-OCT An eighth-wave plate was measured demonstrate the detection accuracy. The optic...

The relevance of visualizing scleral fiber orientation may offer insights into the pathogenesis pathologic myopia, including dome-shaped maculopathy (DSM).

Fiber-based high-speed polarization-sensitive Fourier domain optical coherence tomography (PS-FD-OCT) is developed at 840 nm wavelengh using polarization modulation method.The incident state of modulated along B-scan.The spectrometer has a polarizing beamsplitter and two line-CCD cameras operated line rate 27.7 kHz.From the 0th 1st orders spatial frequencies B-scanning, depth-resolved Jones matrix can be derived.Since continuous B-scan causes fringe washout, equivalent discrete applied to...

purpose. To evaluate the birefringence properties of eyes with age-related macular degeneration (AMD). compare information from two techniques—scanning laser polarimetry (GDx) and polarization-sensitive spectral-domain optical coherence tomography (OCT)—and investigate how they complement each other. methods. The authors prospectively examined healthy subjects 13 patients exudative AMD. Using scanning polarimetry, computed phase-retardation maps, average reflectance images, depolarized light...

Line-field spectral domain optical coherence tomography (LF-SDOCT) has been developed for very high-speed three-dimensional (3D) retinal imaging.By this technique, the A-line rate significantly improved to 823,200 A-lines/s single frame imaging and 51,500 continues imaging.The at is 201 fps.This 3D acquisition speed more than two fold higher standard flying spot SD-OCT.In paper, integration time of camera was optimized in vivo measurement degradation lateral resolution due ocular aberrations...

We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs glaucoma patients treated trabeculectomy, corneas keratoconus keratoplasty were measured PS-OCT. Birefringence formations in trabeculectomy bleb 1 control eye 3 eyes model rabbits. Polarization insensitive scattering OCT the depth-resolved birefringence simultaneously Abnormal was observed cases with advanced thinning rupture...

Purpose: To determine the structural characteristics of peripapillary sclera in myopic eyes using polarization-sensitive optical coherence tomography (PS-OCT). Methods: Patients with myopia who underwent PS-OCT imaging between April and June 2023 were studied. The intensity, optic axis, birefringence images analyzed to surface lamina cribrosa (LC). direction arrangement scleral collagen fibers region ridge determined. Results: One hundred ten 59 patients (mean axial length, 30.00 ± 1.98 mm)...

Purpose: To investigate the arrangement and orientation of collagen fibers in inner outer scleral layers at edges posterior staphylomas using polarization-sensitive optical coherence tomography (PS-OCT). Methods: 195 eyes 105 highly myopic patients who underwent PS-OCT examinations between August 2023 May 2024 Institute Science Tokyo were studied. The images analyzed to assess birefringence staphyloma edges, covering macular inferior staphylomas. Results: Eighty-eight 60 whose confirmed...

Purpose: To investigate the collagen fiber arrangement around emissary canals in posterior sclera. Methods: One hundred sixty-five eyes of 93 patients who underwent polarization-sensitive optical coherence tomography (PS-OCT) examinations 2019 Institute Science Tokyo were studied. Multimodal imaging, including streamline images derived from PS-OCT data, B-scan images, and indocyanine green angiography (ICGA) was used to scleral pits vivo. Additionally, porcine sclera examined using scanning...

A set of fully automated algorithms that is specialized for analyzing a three-dimensional optical coherence tomography (OCT) volume human skin reported.The algorithm first determines the surface OCT volume, and depth-oriented provides mean epidermal thickness, distribution map epidermis, segmented epidermis.Subsequently, an en face shadowgram produced by to visualize infundibula in with high contrast.The population occupation ratio are provided histogram-based thresholding distance mapping...

Polarization-sensitive optical coherence tomography (PS-OCT) can measure cross-sectional and volumetric images of birefringence in fibrous tissues that provides additional contrast to the intensity images.In this study, we develop polarization-sensitive swept-source OCT (PS-SS-OCT) at 1 μm for deep penetration sclera lamina cribrosa posterior part human eyes.A calibration method polarization mode dispersion a circulator, which is employed conserve power interferometer achieve system...

We performed an in vivo three-dimensional analysis of anisotropic changes the dermal birefringence mechanically deformed human skin using polarization-sensitive optical coherence tomography (PS-OCT).The papillary-dermal forehead increased significantly when was shrunk parallel to body axis, and decreased perpendicular axis.En-face images revealed variations among individual subjects, that both shrinking stretching axis promoted formation macro rope-like birefringent domains.We found PS-OCT...

To investigate the tissue properties of keratoconic and normal corneas in vivo by using polarization-sensitive optical coherence tomography (PS-OCT), to evaluate early keratoconus area under receiver operating characteristic curve (AUROC) Mahalanobis distance analysis.Thirty-one eyes 20 patients with keratoconus, 7 suspect, 25 subjects were investigated PS-OCT corneal anterior segment (CAS)-OCT. Average en face phase retardation posterior surface cornea, curvature, videokeratographic...

Polarization-sensitive optical coherence tomography (PS-OCT) is known to be advantageous because of its additional tissue-specific contrast the anterior eye. So far, this advantage has been shown only qualitatively. We evaluate improved visibility afforded by 3-D PS corneal and eye segment OCT (PS-CAS-OCT) in visualizing trabecular meshwork (TM) based on statistical evidences. A total 31 normal subjects participated study. The segments both eyes are scanned using a custom-made PS-CAS-OCT...

Polarization-sensitive swept-source optical coherence tomography (PS-SS-OCT) is used to measure three-dimensional phase-retardation images of birefringent biological tissue in vivo. PS-SS-OCT with continuous source polarization modulation multiplex the incident states signal frequency each A-scan. Although it offers advantage measurement speed that as high standard SS-OCT, its disadvantage low axial range. To overcome this drawback, we employed B-M-mode scan (BM-scan) method, which removes...