A5101908677- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Ophthalmology and Eye Disorders
- Intraocular Surgery and Lenses
- Chemokine receptors and signaling
- Alzheimer's disease research and treatments
- Vascular Malformations Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cerebral Venous Sinus Thrombosis
- Glycosylation and Glycoproteins Research
- Connexins and lens biology
- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
- T-cell and B-cell Immunology
- Protease and Inhibitor Mechanisms
- Microscopic Colitis
- Optical Coherence Tomography Applications
- Corneal Surgery and Treatments
Tokyo Medical and Dental University
2015-2024
Institute of Science Tokyo
2024
MultiMedica
2016
Instituto de Microcirugía Ocular
2016
Japan Society for the Promotion of Science
2016
Johns Hopkins University
2014
Tokyo Women's Medical University
2003
Tokyo Institute of Psychiatry
1994
Osaka Red Cross Hospital
1992
Mie University
1984
Drusen are extracellular deposits that lie beneath the retinal pigment epithelium (RPE) and earliest signs of age-related macular degeneration (AMD). Recent proteome analysis demonstrated amyloid β (Aβ) deposition was specific to drusen from eyes with AMD. To work toward a molecular understanding development AMD drusen, we investigated effect Aβ on cultured human RPE cells as well ocular findings in neprilysin gene–disrupted mice, which leads an increased Aβ. The results showed treatment...
Purpose: To examine posterior staphylomas by widefield optical coherence tomography (WF-OCT) and three-dimensional magnetic resonance imaging (3D-MRI). Methods: Highly myopic patients (myopic refractive error >8.0 diopters or axial length >26.5 mm) who had previously undergone orbital 3D-MRI were examined WF-OCT. Results: The study included 100 eyes of 57 with a mean age 67.9 ± 10.7 years (range, 44–85 years) 30.0 2.3 mm 25.1–36.5 mm). All detected on the 3D-MRI, except for two very large...
<h3>Importance</h3> Pathologic myopia due to an excessive increase of axial length is associated with severe visual impairments. Systematic analyses determine the rate and risk factors elongation in adults high based on long-term follow-up a large population are needed. <h3>Objective</h3> To myopia. <h3>Design, Setting, Participants</h3> This cohort study used medical records 43 201 patient visits single-hospital database that were collected from January 3, 2011, December 28, 2018. A total...
Abstract One of the earliest signs age‐related macular degeneration (AMD) is formation drusen which are extracellular deposits beneath retinal pigmented epithelium (RPE). To investigate relationship between and AMD, we focused on amyloid β (Aβ), a major component also senile plaques in brain Alzheimer's patients. We previously reported that Aβ was accumulated drusen‐like structure senescent neprilysin gene‐disrupted mice. The purpose this study to influence factor B, main activator...
To investigate the morphological changes that occur during development of an early retinal detachment (RD) from a myopic macular retinoschisis (MRS) by optical coherence tomography (OCT).The OCT images five eyes consecutive patients with MRS who developed RD follow-up period were studied.The progression to RDs went through four stages. In stage 1, appeared show focal irregularity thickness external retina. 2, outer lamellar hole within thickened area and small developed. 3, column-like...
Abstract The results of recent studies have implicated local inflammation and complement activation as the processes involved in pathogenesis age-related macular degeneration (AMD). We demonstrated that amyloid β (Aβ), which is deposited drusen, causes an imbalance angiogenesis-related factors retinal pigment epithelial cells. also shown neprilysin gene-disrupted mice accumulate Aβ, develop several features AMD. purpose this study was to investigate mechanisms development AMD are triggered...
Purpose To assess the prevalence of glaucoma in patients with high myopia defined as myopic refractive error >-8 diopters or axial length ≥26.5 mm. Methods The hospital-based observational study included 172 (336 eyes) a mean age 61.9±12.3 years and 30.1±2.3 mm (range: 24.7–39.1mm). Glaucomatous-type optic discs were by glaucomatous disc appearance. Glaucoma was appearance Goldmann visual field defects not corresponding macular changes. Results Larger area (mean: 3.18±1.94 mm2) associated...