A5087155480- Retinal Diseases and Treatments
- Mast cells and histamine
- Fuel Cells and Related Materials
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Systemic Lupus Erythematosus Research
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Asthma and respiratory diseases
- Chemokine receptors and signaling
- Machine Learning in Materials Science
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Monoclonal and Polyclonal Antibodies Research
- Corneal Surgery and Treatments
- Membrane-based Ion Separation Techniques
- Electrocatalysts for Energy Conversion
- Allergic Rhinitis and Sensitization
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Block Copolymer Self-Assembly
Osaka University Hospital
2022
Toyota Motor Corporation (Japan)
2009-2019
Toyota Motor Corporation (Switzerland)
2018
Tokyo Medical and Dental University
2012-2017
Cincinnati Children's Hospital Medical Center
2011-2015
University of Cincinnati
2011-2013
Emory University
2007-2012
Emory Eye Center
2007-2012
Tottori University
2006-2011
The University of Tokyo
2003-2004
Purpose To assess the prevalence of glaucoma in patients with high myopia defined as myopic refractive error >-8 diopters or axial length ≥26.5 mm. Methods The hospital-based observational study included 172 (336 eyes) a mean age 61.9±12.3 years and 30.1±2.3 mm (range: 24.7–39.1mm). Glaucomatous-type optic discs were by glaucomatous disc appearance. Glaucoma was appearance Goldmann visual field defects not corresponding macular changes. Results Larger area (mean: 3.18±1.94 mm2) associated...
To investigate the 6-year outcome of intravitreal bevacizumab (IVB) to treat eyes with active choroidal neovascularization (CNV) due pathologic myopia.Medical records 36 35 consecutive patients high myopia (refractive error ≥8 D or axial length ≥26.5 mm) and CNV, who had been treated IVB followed for ≥6 years were analyzed. The factors that predicted best-corrected visual acuity (BCVA) at 6 after determined by multiple regression analyses.The mean age subjects was 58 years, 29 mm. Twenty-one...
Using dissipative particle dynamics we model phase separation within block and grafted polymers composed of hydrophobic (A) hydrophilic, acid-containing (C) beads. The have their hydrophilic beads located at the end side chains. Pore morphologies are calculated a hydration level λ 4 H2O molecules/C bead. Monte Carlo tracer diffusion calculations used to restricted movement water pore networks. For find that fixed C bead fractions, or ion exchange capacity (IEC), an increase in length results...
We present a simulation tool in order to predict gas permeation through heterogeneous, microphase separated structures. The method combines dissipative particle dynamics (DPD) with kinetic Monte Carlo (KMC). Morphologies obtained from DPD are mapped onto high density grid on which diffusion takes place. Required input parameters for the KMC calculations solubility and constant within each of pure phase components. Our was tested validated H2, O2, N2 gasses hydrated Nafion membranes at...
Using dissipative particle dynamics pore morphologies within model ionomer membranes are simulated. The ionomers composed of hydrophobic backbones and side chains that end-linked with a hydrophilic acid containing site. separation distance between successive branching points is bi-modal, being alternating short (distance x) long y). dependence morphology on ion exchange capacity investigated. Phase separated were calculated at water content 16 vol. %. An increase chain density results in...
We have established methods to evaluate key properties that are needed commercialize polyelectrolyte membranes for fuel cell electric vehicles such as water diffusion, gas permeability, and mechanical strength. These based on coarse-graining models. For calculating diffusion permeability through the membranes, dissipative particle dynamics–Monte Carlo approach was applied, while strength of hydrated membrane simulated by coarse-grained molecular dynamics. As a result our systematic search...
We determined whether multiscale data can be predicted using machine learning <italic>via</italic> a self-assembly functional material system.
Percolation thresholds for diffusion within the pores of hydrated grafted model polymer membranes are estimated by employing dissipative particle dynamics (DPD) in combination with Monte Carlo (MC) tracer calculations. The backbones composed hydrophobic A beads to which side chains y consecutively connected attached end linked a hydrophilic acidic site (C bead). distributed equidistant along every x backbone bead. For ten chain architectures phase separated morphologies were calculated DPD...
Monocytes/macrophages play a key role in host defense by phagocytosing invaded pathogens, presenting antigens to immune cells and producing numerous inflammatory mediators. Although the expression of many proteins genes has been described be up-regulated activated human monocytes, complete picture pathophysiological function monocytes not yet drawn. In this study serial analysis gene (SAGE) procedure was applied lipopolysaccharide (LPS)-stimulated monocytes. A total 35,874 tags corresponding...
To investigate structural features of the posterior episclera and Tenon's capsule in patients with high myopia.This hospital-based observational study included highly myopic eyes (myopic refractive error > -8 diopters or axial length ≥26.5 mm) which sclera its full thickness could be visualized on swept-source optical coherence tomography (OCT) images all 12 radial scans centered fovea. We assessed capsule.The 278 175 (mean age, 60.9 ± 11.4 years; range, 32-89 length, 30.7 1.9 mm; 26.5-36.6...
<h3>Background/aims</h3> Allergic conjunctivitis is characterised by early-phase clinical symptoms and late-phase inflammation in the conjunctiva. The role of different chemokine receptors allergic conjunctivitis, especially during reaction, still unclear. We investigated importance CC receptor (CCR) 3 a murine model IgE-mediated using CCR3-deficient (CCR3<sup>−/−</sup>) mice. <h3>Methods</h3> was initiated wild-type (WT) CCR3<sup>−/−</sup> mice passive transfer ragweed (RW)-specific IgE,...
Herpetic stromal keratitis (HSK) is an immunopathological reaction to herpes simplex virus type 1 (HSV-1) corneal infection. It has been reported that CD4+ cells play the most important role in pathogenesis of this disease. In study, we have focused on two chemokine receptors, CCR5 and CXCR3, which are expressed Th1 mice HSK model.CCR5-deficient (CCR5KO), CXCR3-deficient (CXCR3KO), CCR5/CXCR3 double-deficient (DKO), wild (WT) (C57/BL6 background) were infected intracorneally with HSV-1 (CHR3...
There have been no reports describing polypoidal choroidal vasculopathy (PCV) in eyes with retinitis pigmentosa (RP). A 63-year-old woman who had diagnosed as having RP was referred to us because of sudden onset blurred vision her right eye. Funduscopic examination revealed retinal findings typical both eyes. The macular area the fundus showed lesions massive hemorrhages. Fluorescein angiography and indocyanine green multiple lesions. Optical coherence tomography a large hemorrhagic pigment...
To report the swept-source optical coherence tomographic (OCT) findings in two eyes with choroidal metastases. Two patients metastasis were studied. The was from a breast cancer Case 1 and lung 2. In 1, OCT showed highly reflective solid tumor low tissues that had replaced tissue. Swept-source able to image mass where other fundus imaging methods such as fluorescein angiography did not show mass. Ophthalmoscopy of 2 hemorrhages inner retina, on tumor, vitreous. subretinal steeple-crowned cap...