A5038600999- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Proteoglycans and glycosaminoglycans research
- Connexins and lens biology
- Intraocular Surgery and Lenses
- Cell Adhesion Molecules Research
- Advanced Glycation End Products research
- Wound Healing and Treatments
- Medical and Biological Ozone Research
- Herpesvirus Infections and Treatments
- Legionella and Acanthamoeba research
- Retinal and Optic Conditions
- Connective tissue disorders research
- Antifungal resistance and susceptibility
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Drug-Induced Ocular Toxicity
- Aldose Reductase and Taurine
- RNA Interference and Gene Delivery
- Fibroblast Growth Factor Research
Hiroshima University
2016-2025
Hiroshima Prefectural Hospital
2023-2024
Hiroshima University Hospital
2011-2023
Chiba University Hospital
2023
Yazaki (United States)
2023
Hiroshima City University
2019
Yamaguchi University
2003-2012
Yamaguchi University Hospital
1998-2011
Kōchi University
2011
Kochi Medical School Hospital
2011
purpose. The purpose of this study was to evaluate the ability second-harmonic imaging identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. methods. Six corneas from eye bank donors 13 patients with keratoconus, obtained after penetrating keratoplasty were examined. A femtosecond titanium-sapphire laser 800-nm output used generate signals collected at 400 nm central paracentral tissue blocks. Three-dimensional (3-D) data sets...
Abstract We developed an AI system capable of automatically classifying anterior eye images as either normal or indicative corneal diseases. This study aims to investigate the influence AI’s misleading guidance on ophthalmologists’ responses. cross-sectional included 30 cases each infectious and immunological keratitis. Responses regarding presence infection were collected from 7 specialists 16 non-corneal-specialist ophthalmologists, first based alone then after presenting classification...
Lens epithelial cells (LECs) undergo epithelial-mesenchcymal transition (EMT) after injury and transform into myofibroblasts positive for alpha-smooth muscle actin (alphaSMA), an established marker of this process. Lumican is a keratan sulfate proteoglycan core protein. This study was conducted to examine whether human mouse LECs express lumican injury. To determine may modulate EMT in response or exposure transforming growth factor-beta2 (TGFbeta2), alphaSMA expression by the examined...
Purpose. To examine the possible relation between corneal sensation or tear secretion and stage of diabetic retinopathy in patients. Methods. Total reflex basal were determined 95 patients with type II diabetes mellitus 58 nondiabetic control subjects. Tear was measured by Schirmer test a Cochet-Bonnet esthesiometer. Results. Corneal total significantly reduced compared controls. The loss sensation, but not that secretion, correlated who diagnosed no retinopathy, simple preproliferative...
To determine the kinetics of corneal epithelial maturation during embryonic development and postnatal growth.Expression patterns keratin (K)12 K14 were determined in mouse embryos (embryonic days [E]15.5-19.5), corneas day (P)0 to 10 months, healing after debridement P30 P90 mice. The expression alkaline phosphatase (AP) was growth Krt12(Cre/Cre)/ZAP bitransgenic mice.During development, K12 by peridermal epithelium commenced at E15.5. In period from E15.5 P10, restricted suprabasal and/or...
The aim of this study was to elucidate the mechanisms governing epithelial cell migration and proliferation during wound healing.The authors used healing mouse corneal epithelium examine role TGF-β signaling plays process. To achieve goal, they transgenic mice in which receptor type II (Tbr2) conditionally ablated from epithelium. Epithelium debridement wounds were made, followed by assessment migration, proliferation, immunostaining various pathway components.The showed that absence is...
Purpose: To evaluate the ability of deep learning (DL) models to detect obstructive meibomian gland dysfunction (MGD) using in vivo laser confocal microscopy images. Methods: For this study, we included 137 images from individuals with MGD (mean age, 49.9 ± 17.7 years; 44 men and 93 women) 84 normal glands 53.3 19.6 29 55 women). We constructed trained 9 different network structures used single ensemble DL calculated area under curve, sensitivity, specificity compare diagnostic abilities DL....
Abstract CorneAI, a deep learning model designed for diagnosing cataracts and corneal diseases, was assessed its impact on ophthalmologists’ diagnostic accuracy. In the study, 40 ophthalmologists (20 specialists 20 residents) classified 100 images, including iPhone 13 Pro photos (50 images) diffuser slit-lamp images), into nine categories (normal condition, infectious keratitis, immunological scar, deposit, bullous keratopathy, ocular surface tumor, cataract/intraocular lens opacity, primary...
Purpose. We investigated the combined effects of substance P (SP) and insulin-like growth factor-1 (IGF-1) on corneal epithelial wound closure in vivo. Methods. The epithelium 16 rabbits was debrided by n-heptyl alcohol treatment; SP (1 mg/ml) and/or IGF-1 µg/ml) phosphate-buffered saline (PBS) were administered immediately at 2, 4, 6, 8, 10, 24, 26, 28, 30, 32, 34 hours after debridement. Controls received PBS alone. eyes stained with fluorescein photographed baseline 12, 18, 36, 48 radii...
Purpose. To compare the clinical efficacy of confocal biomicroscopy with that noncontact specular microscopy for evaluation corneal endothelium. Methods. The endothelium was examined in 14 normal subjects (28 eyes) and 6 patients (11 Fuchs endothelial dystrophy using a microscope (SP-2000P, Topcon, Japan) biomicroscope (ConfoScan, Tomey, Japan). images calculated densities cells obtained by 2 techniques were compared. Results. For subjects, almost identical, although density these determined...
To characterize wound closure and phenotypic changes in the corneal epithelium of Goto-Kakizaki (GK) rat, a spontaneous model type 2 diabetes.Corneal healing was monitored by fluorescein staining after epithelial debridement. Tear secretion measured with Schirmer test, sensation evaluated an esthesiometer 13- to 15-week-old GK Wistar (control) rats. The distributions cytokeratin 12 (K12), K14, connexin43 were examined immunohistofluorescence analysis. proliferation capacity cells intact...
purpose. Polyinosinic-polycytidylic acid [poly(I:C)], an analog of viral double-stranded RNA, interacts with Toll-like receptor (TLR)-3 and thereby elicits immunoinflammatory responses characteristic infection. The effects poly(I:C) on the expression proinflammatory cytokines, chemokines, adhesion molecules, as well signaling pathways that underlie such effects, were investigated in cultured human corneal fibroblasts. methods. Expression molecules intercellular molecule (ICAM)-1 vascular...
To investigate the changes in corneal shape and optical performance during after discontinuation of overnight orthokeratology for correction myopia.Both eyes 15 subjects were fitted with reverse-geometry lenses, which then worn >4 hr 52 weeks. Subjects free ocular disease had a corrected visual acuity > or =1.0. Refractive correction, uncorrected acuity, topography, contrast sensitivity (at 4 spatial frequencies) measured under photopic conditions.Refractive error (spherical equivalent)...
Activated corneal fibroblasts and infiltrated leukocytes are thought to contribute ulceration. The potential roles of neutrophil-fibroblast cell-matrix interactions in the degradation stromal collagen associated with ulceration have now been investigated use three-dimensional cultures rabbit cells gels. Degradation fibrils during culture was measured by spectrophotometric determination released hydroxyproline. Whereas alone degraded a small extent, neutrophils did not. However, addition or...