A5018343714- Heat shock proteins research
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Endoplasmic Reticulum Stress and Disease
- Nonmelanoma Skin Cancer Studies
- Facial Rejuvenation and Surgery Techniques
- IgG4-Related and Inflammatory Diseases
- Nasolacrimal Duct Obstruction Treatments
- Cancer and Skin Lesions
- Protein Structure and Dynamics
- Ocular Oncology and Treatments
- Ultrasound and Hyperthermia Applications
- Retinal Imaging and Analysis
- Molecular Biology Techniques and Applications
- Intraocular Surgery and Lenses
- Reconstructive Facial Surgery Techniques
- Vascular Malformations Diagnosis and Treatment
- Facial Trauma and Fracture Management
- thermodynamics and calorimetric analyses
- Botulinum Toxin and Related Neurological Disorders
University of Toyama
2016-2025
Abstract We developed an AI system capable of automatically classifying anterior eye images as either normal or indicative corneal diseases. This study aims to investigate the influence AI’s misleading guidance on ophthalmologists’ responses. cross-sectional included 30 cases each infectious and immunological keratitis. Responses regarding presence infection were collected from 7 specialists 16 non-corneal-specialist ophthalmologists, first based alone then after presenting classification...
Abstract CorneAI, a deep learning model designed for diagnosing cataracts and corneal diseases, was assessed its impact on ophthalmologists’ diagnostic accuracy. In the study, 40 ophthalmologists (20 specialists 20 residents) classified 100 images, including iPhone 13 Pro photos (50 images) diffuser slit-lamp images), into nine categories (normal condition, infectious keratitis, immunological scar, deposit, bullous keratopathy, ocular surface tumor, cataract/intraocular lens opacity, primary...
Hyperthermia (HT) is an important modality in cancer treatment; however, the acquisition of thermal resistance cells due to elevation heat shock proteins (HSPs) makes HT less effective. Accumulating evidence suggests that microRNAs (miRNAs) play role regulating cellular stress sensitivities, such as drug sensitivity and radio-sensitivity, cells. However, few studies have investigated involvement miRNAs sensitivity. The aim this study was thus investigate contribution human oral squamous cell...
Here, to understand the molecular mechanisms underlying cell death induced by sodium fluoride (NaF), we analyzed gene expression patterns in rat oral epithelial ROE2 cells exposed NaF using global-scale microarrays and bioinformatics tools. A relatively high concentration of (2 mM) concomitant with decreases mitochondrial membrane potential, chromatin condensation caspase-3 activation. Using 980 probe sets, identified 432 up-regulated 548 down-regulated genes, that were differentially...
Cold atmospheric pressure plasma (CAP) is known as a source of biologically active agents, such reactive oxygen species (ROS) and nitrogen (RNS). In the present study, we examined effects (N2) on apoptosis changes in gene expression human lymphoma U937 cells exposed to argon (Ar)-CAP. Enormous amounts hydroxyl (·OH) radicals aqueous solution were produced using Ar‑CAP generated 20 kHz low frequency at 18 kV with flow rate 2 l/min. The increase levels ·OH was significantly attenuated by...
Hyperthermia (HT) has been used as a possible treatment modality for various types of malignant tumors. Due to its pleiotropic effects, combined use with radiotherapy and/or chemotherapy proven be beneficial. However, the molecular mechanisms underling cellular responses heat stress remain unclear. Therefore, aim this study was identify common gene expression patterns responsive mild HT (MHT) in human cancer cells. HeLa cervical squamous cell carcinoma (SCC) and HSC-3 oral SCC cells were...
<title>Abstract</title> CorneAI, a deep learning model designed for diagnosing cataracts and corneal diseases, was assessed its impact on ophthalmologists' diagnostic accuracy. In the study, 40 ophthalmologists (20 specialists 20 residents) classified 100 images, including iPhone 13 Pro photos (50 images) diffuser slit-lamp images), into nine categories (normal condition, infectious keratitis, immunological scar, deposit, bullous keratopathy, ocular surface tumor, cataract/intraocular lens...
Bcl‑2‑associated athanogene (BAG) 3, is a member of the BAG protein family and known co‑chaperone heat shock (HSP) 70. BAG3 serves role in regulating variety cellular functions, including cell growth, proliferation death apoptosis. stress‑inducible protein, however constitutive expression level increased cancer cells compared with healthy cells. Recent proteomics technology combined bioinformatics has revealed that participates an interactome number proteins other than its typical partner...
Background: Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), has been shown to play role in anti-apoptosis various malignant tumors. In this study, the expression BAG3 was examined human sebaceous gland carcinoma eyelid. Materials and Methods: The evaluated by immunohistochemistry surgical samples from 5 patients with Results: positive diffusely cytoplasm all patients. average rate 73.0±26.0% tumor cells Conclusion: highly expressed may an important...
Hyperthermia (HT) is considered to be of value as a treatment modality in various cancers. However, the acquisition thermotolerance cancer cells due induction heat shock proteins (HSPs) makes HT less effective. Recent findings have indicated that protein nuclear import factor hikeshi (HIKESHI), also referred C11orf73, acts carrier Hsp70 under stress conditions. The aim present study was determine whether knockdown (KD) HIKESHI by small interfering RNA (siRNA) can potentiate mild (MHT)...
Sebaceous gland carcinoma (SGC) of the eyelid is an uncommon aggressive tumor with a relatively high rate local recurrence and poor prognosis following metastasis. However, molecular mechanisms underlying pathogenesis SGC remain unclear. The purpose present study was to clarify microRNA (miRNA) expression profiles in explore novel miRNA‑mRNA networks SGC. A small RNA‑sequencing analysis performed identify miRNAs differentially expressed between sebaceous adenoma control samples....
Purpose.: Hyperthermia (HT) has been recognized as an effective focal treatment in retinoblastoma. However, one of the problems with HT therapy is that cells acquire acquisition. The purpose this study was to evaluate whether inhibition polo-like kinase 1 (PLK1) would promote sensitivity human retinoblastoma cells. Methods.: We examined effects PLK1 knockdown by small interfering RNA (siRNA) or activity inhibitor (BI-2536) on (44°C, hour) Y79 and WERI-Rb-1 evaluating apoptosis cell...
Purpose . To evaluate the effects of pars plana vitrectomy (PPV) on recurrent macular edema due to branch retinal vein occlusion (BRVO) after intravitreal injections bevacizumab (IVB). Methods This retrospective study included 22 eyes patients who underwent single or multiple IVB for BRVO and showed a recurrence edema. All then PPV were followed up more than 6 months surgery with examinations best corrected visual acuity (BCVA) optical coherence tomography (OCT). OCT parameters central...
Basal cell carcinoma (BCC) is the most frequent malignant tumor of eyelid; it progresses slowly and rarely metastasizes. However, BCC eyelid partially invasive can extend to surrounding ocular adnexa even if appropriate treatment performed. To understand molecular mechanism underlying its pathogenesis, global gene expression analysis surgical tissue samples (n=2) normal human epidermal keratinocytes was performed using a GeneChip® system. The histopathological examination surgically removed...
The most common sites of IgG4-related ocular disease are the lacrimal glands, infraorbital nerve, and extraocular muscles. Other adnexal relatively rare. We report a rare case an 83-year-old man who developed palpebral conjunctivitis following bilateral hypertrophic ectropion eyelid. Tissue immunostaining revealed many IgG4-positive plasma cells (67 IgG4/74 IgG cells/high-power field). serum IgG4 level was 76.9 mg/dL, which within normal range. diagnosis probable disease. possibility should...