A5088178382- Parasite Biology and Host Interactions
- Helminth infection and control
- Lymphoma Diagnosis and Treatment
- Parasites and Host Interactions
- Crustacean biology and ecology
- Peroxisome Proliferator-Activated Receptors
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Advancements in Photolithography Techniques
- Immune Cell Function and Interaction
- Microbial Metabolic Engineering and Bioproduction
- Lipoproteins and Cardiovascular Health
- Electron and X-Ray Spectroscopy Techniques
- Semiconductor Quantum Structures and Devices
- Cancer, Lipids, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Integrated Circuits and Semiconductor Failure Analysis
- Protein Degradation and Inhibitors
- Advanced Semiconductor Detectors and Materials
- Chalcogenide Semiconductor Thin Films
- Coral and Marine Ecosystems Studies
- Retinal and Macular Surgery
- Aquaculture Nutrition and Growth
Kyoto Prefectural University of Medicine
2018-2025
Walter and Eliza Hall Institute of Medical Research
2023
Otsu Municipal Hospital
2023
Tokyo National Hospital
1980-2022
Ehime University
2004-2019
National Cancer Centre Japan
2019
Kyoto first Red Cross hospital
2015-2018
Osaka Women's and Children's Hospital
2018
Tokyo University of Science
2017-2018
Osaka Medical Center for Cancer and Cardiovascular Diseases
2008-2017
A Wnt coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) plays an essential role in bone accrual and eye development. Here, we show that LRP5 is also required for normal cholesterol glucose metabolism. The production of mice lacking revealed deficiency led to increased plasma levels fed a high-fat diet, because the decreased hepatic clearance chylomicron remnants. In addition, when LRP5-deficient showed markedly impaired tolerance. islets had marked reduction intracellular...
Using peptide sequences derived from bovine cardiac acetyl-CoA synthetase (AceCS), we isolated and characterized cDNAs for a murine enzyme designated AceCS2. We also cDNA encoding hepatic type enzyme, AceCS1, identical to one reported recently (Luong, A., Hannah, V. C., Brown, M. S., Goldstein, J. L. (2000) Biol. Chem. 275, 26458–26466). Murine AceCS1 AceCS2 were purified homogeneity characterized. Among C2–C5 short medium chain fatty acids, both enzymes preferentially utilize acetate with...
We report herein the cDNA cloning of a novel rat acyl-CoA synthetase (ACS) that preferentially uses arachidonate and eicosapentaenoate. This newly identified ACS (designated ACS4) contains 670 amino acids is 68% identical to ACS3, previously characterized highly expressed in brain. ACS4 was overproduced Escherichia coli resulting enzyme purified homogeneity. The utilizes eicosapentaenoate most among C 8 –C 22 saturated fatty 14 unsaturated acids. Kinetic analyses revealed has high affinity...
Isolation and characterization of a rat brain cDNA identified third acyl-CoA synthetase (ACS) designated ACS3. The deduced amino acid sequence the revealed that ACS3 consists 720 acids exhibits structural architecture common to ACSs from various origins. expressed in COS cells was purified near homogeneity. resolved by SDS-polyacrylamide gel electrophoresis into two major proteins 79 80 kDa. Cell-free translation synthetic mRNA encoding entire region isoforms were derived same mRNA. utilizes...
Journal Article A Novel Acyl-CoA Synthetase, ACS5, Expressed in Intestinal Epithelial Cells and Proliferating Preadipocytes Get access Eisaku Oikawa, Oikawa *Tohoku University Gene Research Center, School of Medicine, Tohoku UniversitySendai 981-8555 Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroaki Iijima, Iijima Takashi Suzuki, Suzuki †Department Pathology, Hironobu Sasano, Sasano Hiroyuki Sato, Sato Akihisa Kamataki, Kamataki Hiroshi Nagura, Nagura...
Complementary DNA clones encoding a protein highly homologous to the previously characterized long-chain acyl-CoA synthetase (LACS) in liver were isolated from rat brain cDNA libraries. This consists of 697 amino acids and has 64.7% identity with LACS sequence. The share essentially same domain structure, having two regions similar those click beetle luciferase long discrete gap flanking domains. A significant sequence similarity was found between malaria octapeptide-repeat antigen,...
LDL receptor-related protein 5 (LRP5) plays multiple roles, including embryonic development and bone accrual development. Recently, we demonstrated that LRP5 is also required for normal cholesterol metabolism glucose-induced insulin secretion. To further define the role of in lipoprotein metabolism, compared plasma lipoproteins mice lacking LRP5, apolipoprotein E (apoE), or both (apoE;LRP5 double knockout). On a chow diet, apoE;LRP5 knockout (older than 4 months age) had ∼60% higher levels...
Apolipoprotein E allele epsilon4 (apoE4) is a strong risk factor for developing Alzheimer's disease (AD). Secreted apoE has critical function in redistributing lipids among central nervous system cells to maintain normal lipid homeostasis. In addition, previous reports have shown that apoE4 cleaved by protease neurons generate apoE4(1-272) fragment, which associated with neurofibrillary tanglelike structures and mitochondria, causing mitochondrial dysfunction. However, it still remains...
Abstract Sarcopenia is a crucial factor in the physical fitness of elderly individuals. This study investigated prognostic values multiple parameters sarcopenia association with established factors Japanese patients diffuse large B cell lymphoma (DLBCL). As candidate indicators for sarcopenia, skeletal muscle index (SMI) (cm 2 /m ), psoas index, erector spinae visceral fat subcutaneous and to area ratio at third lumbar level were assessed by computed tomography their initial diagnosis 102...
The isolation and characterization of rabbit human cDNAs revealed a new low density lipoprotein receptor (LDLR)-related protein (LRP) designated as LRP5. Human LRP5 cDNA encodes 1,616-amino acid type I membrane-like with three ligand binding repeats in its extracellular region. LDLR-deficient cells transduced by recombinant adenovirus containing exhibited increased apolipoprotein E (apoE)-enriched β-migrating very lipoprotein. Northern blotting situ hybridization high level expression...
The tegumental structures of newly excysted juveniles and adult worms Clonorchis sinensis were studied using scanning transmission electron microscopy. After excystation the juvenile's surface is characterized by knoblike protuberances armed almost entirely with numerous rows small spines encircling body. These are double- or triple-pointed on anterior portion body become single-pointed posteriorly. Four types presumed sensory observed as follow: A) ciliated papillae B) nonciliated platelike...
ABSTRACT In mammalian developing brain, neuronal migration is regulated by a variety of signaling cascades, including Reelin signaling. glycoprotein that mainly secreted Cajal–Retzius neurons in the marginal zone, playing essential roles formation layered neocortex via its receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein (VLDLR). However, precise mechanisms which controls process remain unclear. To gain insight into how individual migrating neurons, we...
Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAE-CTL) is a rare subtype of with poor prognosis. We herein report case PCAE-CTL accompanied by anti-Ma2 antibody-positive paraneoplastic encephalitis. A 33-year-old woman erythema and disturbance consciousness was diagnosed skin biopsy. Head magnetic resonance imaging revealed bilateral medial temporal lobe hyperintensity, antibody in the cerebrospinal fluid positive. She concurrent In cases brain lesions,...
Abstract A retrospective study of extranodal natural killer/T-cell lymphoma (ENKL) patients diagnosed between 2014 and 2021 in Japan was conducted. Among 351 with sufficient data, 116 (33%) were the advanced stage (5 III 111 IV) at diagnosis, further analyzed. The median age 60 years (range: 19–90), 68 (59%) male. Ninety-four (85%) IV had two or more involvements. most common first-line regimen SMILE (steroid, methotrexate, ifosfamide, L-asparaginase, etoposide; 52%). 2-year overall survival...
Despite the oncogenic roles of serine/threonine kinase PDPK1 and its key effectors, RSK2 AKT, their activation status prognostic significance remain unexamined in B cell lymphomas (BCLs). This study evaluated phosphorylation states PDPK1, RSK2-N-terminal domain (NTKD), AKT through immunohistochemical analyses 468 biopsied samples from patients with nine subtypes MLs, including diffuse large lymphoma (DLBCL) (n = 277) follicular (FL) 121). was frequently phosphorylated most subtypes, showing...
This study retrospectively aimed to assess the real-world efficacy and safety of polatuzumab vedotin with bendamustine rituximab for relapsed/refractory diffuse large B-cell lymphoma, analyzing 72 patients within Kyoto Hematology Clinical Study Group. The median age was 77, one-third participants over 80 half having previously received three or more lines treatment. overall response rate 73.6%, including 45.8% complete response. progression-free survival (PFS) 7.6 months. Poor performance...
By expression cloning using fluorescent-labeled high density lipoprotein (HDL), we isolated two clones that conferred the cell surface binding of HDL. Nucleotide sequence revealed one corresponds to scavenger receptor class B, type 1 (SRBI) and other encoded a novel protein with 228 amino acids. The primary structure newly identified HDL-binding resembles GPI-anchored proteins consisting an N-terminal signal sequence, acidic region cluster aspartate glutamate residues, Ly-6 motif highly...
A novel one-step soft solution-processing route called the solvothermal-copolymerization technique was successfully developed for in situ fabrication of polystyrene (PS)/CdS nanocomposites embedded with CdS nanowires ethylenediamine media at lower temperatures (80−140 °C). In this route, polymerization monomers and formation nanocrystallites occur simultaneously a certain temperature range. The results X-ray powder diffraction, transmission electron microscopy, high-resolution microscopy...
Acetyl-CoA synthetase 2 (AceCS2) produces acetyl-CoA for oxidation through the citric acid cycle in mitochondrial matrix. AceCS2 is highly expressed skeletal muscle and robustly induced by fasting. Quantification of transcripts both C2C12 human myotubes indicated that fasting-induced gene expression appears to be independent on insulin action. Characterization 5′-flanking region mouse demonstrates Krüppel-like factor 15 (KLF15) plays a key role trans-activation gene. Deletion mutation...
The use of chimeric antigen receptor T-cell (CAR-T) therapy for hematologic malignancies is rapidly increasing, and appropriately managing adverse events (AEs) crucial. Cytokine release syndrome (CRS) a common AE CAR-T therapy, characterized by systemic symptoms such as fever respire-circulatory failure. We present two cases with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) accompanied rare complication cervical local CRS an acute inflammatory reaction at specific site after...