A5101549117- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Prostate Cancer Treatment and Research
- Plant Stress Responses and Tolerance
- Medical Imaging Techniques and Applications
- Alcohol Consumption and Health Effects
- Tea Polyphenols and Effects
- Advanced ceramic materials synthesis
- Antioxidant Activity and Oxidative Stress
- Cell Adhesion Molecules Research
- ZnO doping and properties
- Kidney Stones and Urolithiasis Treatments
- Diet, Metabolism, and Disease
- Drug-Induced Hepatotoxicity and Protection
- Phytoestrogen effects and research
- Fiber-reinforced polymer composites
- Hormonal and reproductive studies
- Multiple and Secondary Primary Cancers
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Ga2O3 and related materials
- GABA and Rice Research
- Cancer Treatment and Pharmacology
- Free Radicals and Antioxidants
- Biochemical Analysis and Sensing Techniques
Okayama University
1987-2025
Taisei (Japan)
2023
Kobe University
2011-2019
University of Shizuoka
2014-2016
Tokushima University
2012-2015
National Center for Geriatrics and Gerontology
2009-2015
Nagasaki University
2011-2012
University of Hyogo
2010-2011
Gifu University
1988-2007
Gifu Red Cross Hospital
1994-2005
Apolipoprotein E allele epsilon4 (apoE4) is a strong risk factor for developing Alzheimer's disease (AD). Secreted apoE has critical function in redistributing lipids among central nervous system cells to maintain normal lipid homeostasis. In addition, previous reports have shown that apoE4 cleaved by protease neurons generate apoE4(1-272) fragment, which associated with neurofibrillary tanglelike structures and mitochondria, causing mitochondrial dysfunction. However, it still remains...
Aldehyde dehydrogenases (ALDHs) are the major enzyme superfamily for aldehyde metabolism. Since ALDH polymorphism leads to accumulation of acetaldehyde, we considered that enhancement liver activity by certain food ingredients could help prevent alcohol-induced chronic diseases. Here, evaluated modulating effects 3-hydroxyphenylacetic acid (OPAC), metabolite quercetin glycosides, on and acetaldehyde-induced cytotoxicity in cultured cell models. OPAC significantly enhanced total not only...
The antihyperglycemic effects of tea are well documented. However, the fermented on translocation glucose transporter 4 (GLUT4), major for uptake in postprandial period, skeletal muscle and underlying molecular mechanisms not fully understood. This study investigated GLUT4 its related signaling pathways male ICR mice given tea. Intake oolong, black, or pu-erh 7 days enhanced to plasma membrane muscle. Each type stimulated phosphorylation phosphoinositide 3-kinase (PI3K), Akt/protein kinase...
Abstract Salt stress increases levels of reactive oxygen species (ROS), leading to a variety damages in plants. Production carbonyl (RCS) following ROS accumulation has been reported be closely related damage by salt stress. We investigated effects RCS scavengers, carnosine and pyridoxamine, on inhibition germination seedling growth Nipponbare (Oryza sativa L.) The the 50 mM NaCl was alleviated scavengers. scavengers suppressed malondialdehyde protein carbonylation but not salt-stressed...
The antioxidant property of plasma high-density lipoprotein (HDL) is thought to be involved in potential anti-atherogenic effects but the exact mechanism not known. We aimed reveal contribution HDL on elimination lipid hydroperoxides (LOOH) derived from oxidized low-density (LDL). Oxidized LDL prepared by copper ion-induced oxidation contained nonesterified fatty acid (FFA-OOH) and lysophosphatidylcholine (lysoPtdCho), addition cholesteryl ester (CE-OOH) phosphatidylcholine (PtdCho-OOH). A...
Abstract We purified several hundred mgs of four major theaflavins (theaflavin, theaflavin-3-O-gallate, theaflavin-3′-O-gallate, and theaflavin-3,3′-O-digallate). Among the 25 hTAS2Rs expressed in HEK293T cells, hTAS2R39 hTAS2R14 were activated by theaflavins. Both responded to theaflavin-3′-O-gallate. In addition, was theaflavin theaflavin-3,3′-O-gallate, but not theaflavin-3-O-gallate. contrast,
Scope The effect of food combination on metabolic profile in postprandial plasma has hardly been reported. We investigated the absorption and metabolism quercetin soy isoflavones humans after meal consumption. Methods results Five healthy volunteers ingested sautéed onion tofu, metabolites were analyzed. Quercetin genistein incubated with human intestinal C aco‐2 cells hepatoma H ep G 2 to further analyze influence simultaneous supply small intestine liver. Glucuronosyl conjugates methylated...
3,4-Dihydroxyphenylacetic acid (DOPAC) is one of the major colonic microflora-produced catabolites quercetin glycosides, such as 4'-glucoside derived from onion. Here, we investigated whether DOPAC modulates aldehyde dehydrogenase (ALDH) activity and protects cells acetaldehyde-induced cytotoxicity in vitro. was shown to enhance not only total ALDH activity, but also gene expression ALDH1A1, ALDH2 ALDH3A1 a concentration-dependent manner. simultaneously stimulated nuclear translocation...
Selenium (Se) causes oxidative damage to plants. Proline is accumulated as a compatible solute in plants under stress conditions and mitigates stresses. Selenate at 250 µM increased cell death inhibited the growth of tobacco BY-2 cells while exogenous proline 10 mM did not mitigate inhibition by selenate. accumulation Se ROS activities antioxidant enzymes but lipid peroxidation cells. enzyme either or selenate-stressed Glutathione (GSH) rather than ascorbic acid (AsA) mitigated although both...
Abstract Myrosinase (β-thioglucoside glucohydrolase, enzyme nomenclature, EC 3.2.1.147, TGG) is a highly abundant protein in Arabidopsis guard cells, of which TGG1 and TGG2 function redundantly abscisic acid (ABA)- methyl jasmonate-induced stomatal closure. Reactive carbonyl species (RCS) are α,β-unsaturated aldehydes ketones, downstream reactive oxygen (ROS) production the ABA signalling pathway cells. Among RCS, acrolein most reactive, significantly produced ABA-treated To clarify signal...
Since brown rice extract is a rich source of biologically active compounds, the present study aimed to quantify major compounds in and compare their cytoprotective potential against oxidative stress. The content main hydrophobic followed order cycloartenyl ferulate (CAF) (89.00 ± 8.07 nmol/g) >> α-tocopherol (αT) (19.73 2.28 > γ-tocotrienol (γT3) (18.24 1.41 α-tocotrienol (αT3) (16.02 1.29 γ-tocopherol (γT) (3.81 0.40 nmol/g). However, percent contribution CAF radical scavenging...
The aim of this study is to investigate the modulating effect coexisting food components on absorption and metabolism quercetin blood plasma antioxidant potentials. combination with α-tocopherol (αT), cellulose, or a commercially available vegetable beverage containing αT dietary fiber was orally administered mice. Compared single administration aglycone, coadministration significantly increased concentration at 0.5 h, whereas cellulose decreased it. Interestingly, mixed showed no...
ABSTRACT Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection in ALDH1A1-deficient mutant (aldh1a1-kd) weaker than that wild type. Furthermore, did not enhance ALDH activity aldh1a1-kd cells, suggesting ALDH1A1 is involved cytoprotection.
Nickel catalyzes the multicomponent coupling reaction of vinyl epoxides, alkynes, and dimethylzinc to provide hepta-2,5-dienyl alcohols as a mixture <i>E</i>- <i>Z</i>-isomers in high yields. Vinylcyclopropane participates similar afford dimethyl α-(hepta-2,5-dienyl)malonates with excellent <i>E</i>-stereoselectivity.