A5049300446- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Receptor Mechanisms and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion Transport and Channel Regulation
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Heart Rate Variability and Autonomic Control
- Food Allergy and Anaphylaxis Research
- Parathyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- Magnesium in Health and Disease
- Chronic Kidney Disease and Diabetes
- Neuroscience of respiration and sleep
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- High Altitude and Hypoxia
- Cardiovascular Syncope and Autonomic Disorders
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
International University of Health and Welfare
2017-2025
Japanese Society of Hypertension
2021
Japan Science and Technology Agency
2016-2020
Mita Hospital
2018
The University of Tokyo
2008-2017
University of Tokyo Hospital
1997-2017
Teikyo University
2017
Tianjin First Center Hospital
2017
Tianjin Medical University
2017
Japan Agency for Medical Research and Development
2017
Adrenomedullin (AM), a potent vasodilator peptide, is produced by posttranslational splicing of pro-adrenomedullin together with proadrenomedullin N-terminal 20 peptide (PAMP), another hypotensive peptide. Although both AM and PAMP have the potential not only to decrease blood pressure but also protect organs from damage, there no direct evidence for their individual physiological roles in vivo.Using knockout mice disruption alone, we investigated organ-protective effect AM. AM(-/-) mutation...
Hypertension is a leading contributor to cardiovascular mortality worldwide. Despite this, its underlying mechanism(s) and the role of excess salt in cardiorenal dysfunction are unclear. Previously, we have identified cross-talk between mineralocorticoid receptor (MR), nuclear transcription factor regulated by steroid aldosterone, small GTPase Rac1, which implicated proteinuric kidney disease. We here show that high-salt loading activates Rac1 kidneys rodent models salt-sensitive...
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Nuclear factor-κB (NF-κB) signaling plays critical roles in physiological and pathological processes such as responses to inflammation oxidative stress.To examine the role of endothelial NF-κB vivo, we generated transgenic mice expressing dominant-negative IκB under Tie2 promoter/enhancer (E-DNIκB mice). These exhibited functional inhibition specifically cells. Although E-DNIκB displayed no overt phenotypic changes when young lean, they were protected from development insulin resistance...
Abstract Excessive salt intake is one of the causes hypertension, and reducing important for managing risk hypertension subsequent cardiovascular events. Esaxerenone, a mineralocorticoid receptor blocker, has potential to exert an antihypertensive effect in hypertensive patients with excessive intake, but evidence still lacking, especially clinical settings. We aimed determine if baseline sodium/potassium ratio estimated 24-h urinary sodium excretion can predict esaxerenone essential...
Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells liver, inhibits via S1P receptor 2 (S1P(2)) hepatocytes rats vitro. A potential role of S1P(2) liver regeneration fibrosis was examined S1P(2)-deficient mice. Nuclear 5-bromo-2'-deoxy-uridine labeling, proliferating cell nuclear antigen (PCNA) staining hepatocytes, ratio weight to body were enhanced at 48 h mice after single...
Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia media. However, relatively little is known about mechanistic significance of endothelium pathogenesis these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB) regulates expressions numerous genes, including those related to pro-inflammatory responses. Therefore, investigate roles endothelial responses, we examined impact blocking NF-κB signalling on...
Abstract The EXCITE-HT study aimed to evaluate the efficacy and safety of esaxerenone versus thiazide diuretics (trichlormethiazide) as second-line treatment for Japanese patients with uncontrolled essential hypertension. This was a 12-week, multicenter, randomized, open-label, parallel-group study. non-inferiority trichlormethiazide confirmed if upper limit two-sided 95% confidence interval (CI) difference in systolic blood pressure (SBP)/diastolic (DBP) change between groups below 3.9/2.1...
Proadrenomedullin NH(2)-terminal 20 peptide (PAMP) and adrenomedullin, which are derived from proadrenomedullin, exhibit remarkable hypotensive action. We investigated the effect of PAMP adrenomedullin on peripheral sympathetic neutral transmission. Using perfused rat mesenteric arteries, (0, 1, 5, 10 pmol/ml) decreased norepinephrine overflow by periarterial electrical nerve stimulation in a dose-dependent fashion (0.244 +/- 0.043, 0.231 0.048, 0.195 0.061 0.168 0.051 ng/gram tissue weigh:...
Hypertension, insulin resistance, and obesity are common age-related metabolic disorders that often associated with increased oxidative stress the resultant vascular damage. Underlying mechanisms have been suggested, overproduction of is one possible candidate. Since we recently found a vasoactive peptide, adrenomedullin, to be an endogenous antioxidant potently inhibits stress-induced damage, in current study evaluated changes aged mice. Insulin sensitivities young adrenomedullin-deficient...
Although Mg2+ contributes to blood pressure regulation partly in terms of vasodilator action, its sympatholytic effect may also play an important role control pressure. Thus, the present study, we investigated on sympathetic tone and We studied actions response hydralazine, a direct vasodilator, conscious spontaneously hypertensive rats (SHRs), electrical stimulation pithed Sprague-Dawley rat; catecholamine release by peripheral nerve endings; N-type Ca2+ channels cultured neural cells....
Potassium supplementation has a potent protective effect against cardiovascular disease, but the precise mechanism of it left ventricular abnormal relaxation, relatively early functional cardiac alteration in hypertensive subjects, not been fully elucidated. In present study, we investigated potassium salt-induced dysfunction and involved mechanism. Seven- to 8-week-old Dahl salt sensitive rats were fed normal diet (0.3% NaCl) or high-salt (8% with without high KCl) for 8 weeks. Left...
Inflammation and thrombosis coexist in several disorders. Although it is recognized that leukocytes may induce a procoagulant state at sites of inflammation, the critical molecular determinants this process remain largely unknown.
Metabolic syndrome is a highly predisposing condition for cardiovascular disease and could be cause of excess salt-induced organ damage. Recently, several investigators have demonstrated that salt loading causes left ventricular diastolic dysfunction associated with increased oxidative stress mineralocorticoid receptor activation. We, therefore, investigated whether induces cardiac in metabolic via upregulation signals. Thirteen-week-old spontaneously hypertensive rats SHR/NDmcr-cps, the...
Aldosterone plays an important role in regulating Na-Cl reabsorption and blood pressure. Epithelial Na+ channel, Na+-Cl- cotransporter, Cl-/HCO3- exchanger pendrin are the major mediators of transport aldosterone-sensitive distal nephron. Existing evidence also suggests that plasma K+ concentration affects renal handling. In this study, we posited hypokalemia modulates effects aldosterone on hyperaldosteronism. Chronic infusion mice increased levels at membrane, correcting model almost...