A5103255023- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Cardiac Imaging and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
- Intraocular Surgery and Lenses
- Medical Imaging Techniques and Applications
- Geochemistry and Geologic Mapping
- Nicotinic Acetylcholine Receptors Study
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Genomics and Diagnostics
- Mining Techniques and Economics
- Renal cell carcinoma treatment
- Advanced MRI Techniques and Applications
- Abdominal vascular conditions and treatments
- Tryptophan and brain disorders
- Retinal and Macular Surgery
- Neuroscience and Neuropharmacology Research
- Helicobacter pylori-related gastroenterology studies
- Ultrasound and Hyperthermia Applications
- Neuroendocrine Tumor Research Advances
- Eicosanoids and Hypertension Pharmacology
Kobe University
2000-2025
Hyogo University
2024
University of Miyazaki
2017-2018
University of Colorado Anschutz Medical Campus
2014
Wakayama Medical University
2001-2004
Nara Medical University
1992-2004
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2004
AstraZeneca (Japan)
2003
Nara Prefectural Institute of Public Health Research Center
1992-2003
Fukui Red Cross Hospital
2001
Abstract Background Recent evidence suggests that the presence of microbiome within human pancreatic ductal adenocarcinoma (PDAC) tissue potentially influences cancer progression and prognosis. However, significance tumor-resident remains unclear. We aimed to elucidate impact intratumoral bacteria on pathophysiology prognosis PDAC. Methods The was assessed in 162 surgically resected PDACs using quantitative polymerase chain reaction (qPCR) situ hybridization (ISH) targeting 16S rRNA....
Lens epithelial cells (LECs) undergo epithelial-mesenchcymal transition (EMT) after injury and transform into myofibroblasts positive for alpha-smooth muscle actin (alphaSMA), an established marker of this process. Lumican is a keratan sulfate proteoglycan core protein. This study was conducted to examine whether human mouse LECs express lumican injury. To determine may modulate EMT in response or exposure transforming growth factor-beta2 (TGFbeta2), alphaSMA expression by the examined...
Abstract Background Immune checkpoint inhibitor-related pancreatic injury (ICI-PI) is a rare occurrence, which has not been reported in detail. We conducted retrospective multicenter study to determine the clinical characteristics, risk factors, and treatment of ICI-PI. Methods reviewed medical records patients who received ICIs for malignant tumors between April 2014 2019 at 16 participating hospitals. Patients with elevated enzymes or pancreatitis were identified classified using Common...
Abstract Objectives Covered self‐expandable metal stents are commonly used for unresectable malignant distal biliary obstruction. Partially covered have uncovered sections at both ends; however, their anti‐migration effect remains unclear. The objective of this study was to evaluate that by comparing such with fully patients Methods This a multicenter, retrospective comparative partially Stent migration, recurrent obstruction, and the time obstruction were compared between them. Results...
Abstract: Acute toxicity of nicotine was examined in old (24 months) and young (6 weeks) Wistar rats. There were no significant age differences the mortality convulsive responses induced by an intraperitoneal injection (24.5 mg/kg). The lethal levels blood cortex latent period to death rats larger than those Cortical 15 min. after also higher Nicotine significantly increased dopamine, 3,4‐dihydroxyphenylacetic acid homovanillic striatum hippocampus rats, but not Moreover, nicotine‐induced...
Abstract Arsenic is ubiquitous in the environment. Although average arsenic concentrations rocks (∼2 mg kg −1 ), soils freshwater (∼1 m̈g dm −3 seawater ) and organisms generally low, high limited areas are not uncommon. Whereas terrestrial appear to accumulate arsenic, marine effectively concentrate levels thousand of times higher than ocean waters. The geochemical cycle mineralogy reviewed with some emphasis towards Japanese locations (averages, ranges) found samples from lithosphere,...
Endoscopic papillectomy (EP) for benign ampullary neoplasms could be a less-invasive alternative to pancreatoduodenectomy (PD). There are some problems and limitations with EP. The post-EP resection margins of tumors often positive or uncertain because the burning effect clinical outcomes resected margin cases after EP remain unknown.To investigate EP.Between January 2007 October 2018, all patients who underwent at Kobe University Hospital were included in this study. indications as follows:...
Abstract Background Sarcopenia, defined as a loss of skeletal muscle mass and quality, is found in 30–65% patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis, poor prognostic factor. However, it yet to be evaluated why sarcopenia associated prognosis. Therefore, this study elucidated the tumor characteristics PDAC sarcopenia, including driver gene alterations microenvironment. Patients Methods We retrospectively analyzed 162 who underwent surgery between 2008 2017. by...
Objectives Aging is associated with a high prevalence of pancreatic cysts and intraductal papillary mucinous neoplasms (IPMNs). Metabolic syndrome (MS) may increase the risk neoplasms, including those that develop in pancreas. However, influence factors MS on development IPMN remains unclear. Methods A total 9363 patients who underwent abdominal ultrasound examinations between April 2012 May 2013 were included this study. Multivariate logistic regression analysis was performed to identify...
The steady-state plasma concentrations of imipramine and desipramine were measured after a more than 2-week treatment with 0.39 to 1.39 mg/kg/day hydrochloride in 28 Japanese patients major depression who had been phenotyped simultaneously mephenytoin (for CYP2C19-related status) metoprolol CYP2D6-related before initiating the antidepressant therapy. Patients consisted five poor metabolizers (PMs) CYP2C19 an extensive metabolizer (EM) phenotype CYP2D6, whereas remainder EMs for both...
Secondary sclerosing cholangitis, characterized by biliary obstruction, can be caused drugs such as immune checkpoint inhibitors (ICIs). While there a few reports of cholangitis after inhibitor administration, no case has been reported discontinuation drugs.A 68-year-old man who underwent chemotherapy for lung adenocarcinoma with bone metastasis presented abdominal pain and fever 4 mo the final administration pembrolizumab. Computed tomography revealed thickening gallbladder wall dilatation...
It has been demonstrated that embryonic chicken gizzard smooth muscle contains a unique myosin light chain of 23,000 mol wt, called L23 (Katoh, N., and S. Kubo, 1978, Biochem. Biophys. Acta, 535:401-411; Takano-Ohmuro, H., T. Obinata, Mikawa, Masaki, 1983, J. (Tokyo), 93:903-908). When we examined myosins in developing ventricular pectoralis muscles by two-dimensional gel electrophoresis, the (Le) completely comigrates with was detected both striated at early developmental stages. Two...
Abstract Background Abundant collagen deposition is a hallmark of pancreatic ductal adenocarcinomas (PDACs). This study clarified the interactive relationship between tumor-stromal collagen, molecular and immune characteristics, tumor pr ogression in human PDAC. Methods We performed comprehensive examination using an integrative pathological epidemiology database on 169 cases with resected PDAC . The amount was quantified through digital imaging analysis for Elastica van Gieson-stained...
Abstract Endoscopic papillectomy for early ampullary tumors is considered a minimally invasive and useful alternative to pancreatoduodenectomy; however, its indications remain unclear. This study aimed clarify the advantages of endoscopic by investigating clinical outcomes patients who underwent or pancreatoduodenectomy tumors. Patients diagnosed with (adenoma, Tis, T1a) between June 2008 October 2019 were included, their analyzed. Seventy-four (34 adenomas 40 adenocarcinomas) divided into...