A5020171657- Growth Hormone and Insulin-like Growth Factors
- Bird parasitology and diseases
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Adenosine and Purinergic Signaling
- Diet and metabolism studies
- Avian ecology and behavior
- Pesticide Exposure and Toxicity
- Vector-borne infectious diseases
- Nutrition and Health in Aging
- Pulmonary Hypertension Research and Treatments
- Genetic Syndromes and Imprinting
- Study of Mite Species
- Occupational exposure and asthma
- Regulation of Appetite and Obesity
- Vitamin C and Antioxidants Research
- Sulfur Compounds in Biology
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Livestock and Poultry Management
- Parasite Biology and Host Interactions
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Alabama at Birmingham
2015-2024
Aligarh Muslim University
1994-2024
Integral University
2024
The Francis Crick Institute
2024
University of Louisville
2024
Teerthanker Mahaveer Medical College & Research Centre
2024
All India Institute of Medical Sciences
2024
B.S. Abdur Rahman Crescent Institute of Science & Technology
2024
Universidad Iberoamericana
2024
Hayatabad Medical Complex
2024
Summary background Conflicting views are reported on the association between advancing age and gradually diminishing concentrations of serum total testosterone in men. The putative loss diurnal rhythm older men is to be part due low morning when compared found young We have measured total, free bioavailable along with SHBG samples taken every 30 min throughout a 24‐h period 10 eight middle‐aged results Both displayed significant all variables, minimum fall 43% from peak nadir subjects....
Adenosine/adenosine receptor-mediated signaling has been implicated in the development of various ischemic diseases, including retinopathies. Here, we show that adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transcription factor-1 (HIF-1)-dependent endothelial cell glycolysis, which is crucial for pathological angiogenesis proliferative Adora2a expression markedly increased retina mice with oxygen-induced retinopathy (OIR). Endothelial cell-specific, but not macrophage-specific...
During adaptation to hypoxic and hyperoxic conditions, the genes involved in glucose metabolism are upregulated. To probe involvement of transcription factor hypoxia-induced factor-1 (HIF-1) hexokinase (HK) II expression human pulmonary cells, A549 cells small-airway epithelial (SAECs) were exposed stimuli such as hypoxia, deferoxamine (DFO), metal ions. The largest increase HK-II (20-fold for mRNA 2.5-fold enzymatic activity) was observed when DFO. All selectively increased 5.5-kb rather...
Hypoxia, through the hypoxia-inducible transcription factors HIF-1α and HIF-2α (HIFs), induces angiogenesis by up-regulating a common set of angiogenic cytokines. Unlike HIF-1α, which regulates unique genes, most genes regulated overlap with those induced HIF-1α. Thus, contribution remains largely obscure. By using adenoviral mutant constructs, where HIFs are transcriptionally active under normoxic conditions, we show that but not adenosine A 2A receptor in primary cultures human lung...
Polyamines (PAs) are aliphatic polycations that widespread in living organisms. In this review, we focusing the correlation between endogenous PA titers and physiological perturbations on protective role of various analogues PAs against abiotic stresses. involved many processes, such as cell growth development also respond to diverse level shifts different ways depending several factors, plant species, tolerance or sensitivity stress, duration stress. Exogenously supplied protected plants...
Nicotine is a highly addictive principal component of both tobacco and electronic cigarette that readily absorbed in blood. Nicotine-containing cigarettes are promoted as safe alternative to smoking. However, the isolated effects inhaled nicotine largely unknown. Here we report novel rat model aerosolized with particle size (~1 μm) respirable diameter range. Acute inhalation caused increased pulmonary edema lung injury measured by enhanced bronchoalveolar lavage fluid protein, IgM,...
come from teaching and research institutions in France or abroad, public private centers.
Despite the high morbidity and mortality among patients with extensive cutaneous burns in intensive care unit due to development of acute respiratory distress syndrome, effective therapeutics remain be determined. This is primarily because mechanisms leading lung injury (ALI) these unknown. We test hypothesis that chemical promote systemic activation neutrophils, particular, toxicity mediated by deployment neutrophil extracellular traps (NETs). also demonstrate potential benefit a peptidyl...
Respiratory failure is a serious consequence of lung cell injury caused by treatment with high inhaled oxygen concentrations. Human microvascular endothelial cells (HLMVEC) are principal target hyperoxic (hyperoxia). Cell stress can cause release ATP, and this extracellular nucleotide activate purinoreceptors mediate responses essential for survival. In investigation, exposure to an oxidative stress, hyperoxia, rapid but transient ATP (20.03 ± 2.00 nm/106 in 95% O2versus 0.08 0.01 21% O2 at...
Islets isolated from cadaveric donor pancreas are functionally viable and can be transplanted in diabetic patients to reduce insulin requirements. This therapeutic approach is less efficient because a significant portion of functional islets lost due oxidative stress, inflammation, hypoxia. Exendin-4, glucagon-like peptide-1 receptor agonist, known improve islet survival through activation the transcription factor, cAMP response element binding protein (CREB). However, human exposed several...
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The Central Board of Secondary Education (CBSE) and the Indian Certificate (ICSE) are two significant educational boards in India. Furthermore, it is worth noting that every state has its own autonomous State Education. In recent times, IB Cambridge also introduced many schools metropolitan cities country. This research paper aims to compare comprehend major India, specifically (CBSE), (ICSE), International Baccalaureate (IB), Examinations (CIE). seeks elucidate disparities resemblances...
Increased glucose utilization and hexokinase (HK)-II expression are adaptive features of lung cells exposed to hypoxia or hyperoxia. HK-II is the most regulated isoform HK. Whether its overexpression could be protective against oxidative stress was explored in human epithelial-like (A549) cells. overexpressed A549 a tetracycline-repressible retroviral vector system. Elevated confirmed by Western blot activity measurements. Cell death caused exposure hyperoxia decreased HK-II-overexpressing...
OBJECTIVE Adult growth hormone deficiency (AGHD) is characterized by abnormalities in body composition and a poor perceived quality of life (QoL). Weight‐based high‐dose replacement (GHR) results improvements QoL AGHD. However, high patient percentage reported side‐effects on GHR resulting rate withdrawal from (GH) treatment. High‐dose GH therapy also leads to supraphysiological serum insulin‐like factor‐I (IGF‐I) concentrations that have been associated with breast prostate cancer, raising...
Metabolically active cells are able to convert the MTT [3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide] dye blue formazan. This is basis of assay, which among most widely used screening methods evaluate cell viability and proliferation. When testing effects cholesterol products on human pulmonary epithelial-like A549 using trypan staining (cell numbers) results were inconsistent. The assay indicated greater than 50% loss with exposure cholesterol, whereas there was no decrease...
Autopsy specimens from human victims or experimental animals that die due to acute chlorine gas exposure present features of cardiovascular pathology. We demonstrate inhalation-induced reduction in heart rate and oxygen saturation rats. Chlorine inhalation elevated reactants, such as chlorotyrosine chloramine, blood plasma. Using tissue primary cardiomyocytes, we demonstrated high-concentration vivo (500 ppm for 30 min) caused decreased total ATP content loss sarcoendoplasmic reticulum...
Victims of chlorine (Cl2) inhalation that die demonstrate significant cardiac pathology. However, a gap exists in the understanding Cl2-induced dysfunction. This study was performed to characterize dysfunction occurring after Cl2 exposure rats at concentrations mimicking accidental human exposures (in range 500 or 600 ppm for 30 min). Inhalation min resulted increased lactate coronary sinus suggesting an increase anaerobic metabolism by heart. There also attenuation myocardial contractile...
Modern techniques such as microwave treatment clean and uniform in textile processing have been used to make the dyeing process eco-friendly, plus time cost effective.The present study is concerned with effect of irradiation on cotton fabric using Reactive Blue 21 dye.Irradiated (RC) un-irradiated fabrics (NRC) were dyed irradiated (RS) (NRS) dye solution under various conditions.Optimal radiation parameters explore pH, temperature, for getting darker shades.ISO standard color fastness...