A5016272196- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- IgG4-Related and Inflammatory Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Neuroendocrine Tumor Research Advances
- Nutrition and Health in Aging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Omental and Epiploic Conditions
- Cancer Research and Treatments
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
- Colorectal Cancer Screening and Detection
- Hand Gesture Recognition Systems
- Frailty in Older Adults
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
- Sports Dynamics and Biomechanics
- Gut microbiota and health
- Cancer Diagnosis and Treatment
- Mesenchymal stem cell research
- Virtual Reality Applications and Impacts
Kobe University
2020-2024
Tokyo-Kita Medical Center
2016-2019
Aoyama Gakuin University
2019
Abstract Background Recent evidence suggests that the presence of microbiome within human pancreatic ductal adenocarcinoma (PDAC) tissue potentially influences cancer progression and prognosis. However, significance tumor-resident remains unclear. We aimed to elucidate impact intratumoral bacteria on pathophysiology prognosis PDAC. Methods The was assessed in 162 surgically resected PDACs using quantitative polymerase chain reaction (qPCR) situ hybridization (ISH) targeting 16S rRNA....
Abstract Background Sarcopenia, defined as a loss of skeletal muscle mass and quality, is found in 30–65% patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis, poor prognostic factor. However, it yet to be evaluated why sarcopenia associated prognosis. Therefore, this study elucidated the tumor characteristics PDAC sarcopenia, including driver gene alterations microenvironment. Patients Methods We retrospectively analyzed 162 who underwent surgery between 2008 2017. by...
Objectives Aging is associated with a high prevalence of pancreatic cysts and intraductal papillary mucinous neoplasms (IPMNs). Metabolic syndrome (MS) may increase the risk neoplasms, including those that develop in pancreas. However, influence factors MS on development IPMN remains unclear. Methods A total 9363 patients who underwent abdominal ultrasound examinations between April 2012 May 2013 were included this study. Multivariate logistic regression analysis was performed to identify...
In recent years, with the widespread use of wearable devices, in sports field and like, research techniques for analyzing movement are being developed by attaching sensors to a body or gear from acquired data. However, most them require dedicated post-processing computers. Also, there is nothing do on spot provide feedback form skill improvement. this research, we improvement support system using smartwatch screen. We verified whether it can be utilized everyday life. order demonstrate...
Abstract Background Abundant collagen deposition is a hallmark of pancreatic ductal adenocarcinomas (PDACs). This study clarified the interactive relationship between tumor-stromal collagen, molecular and immune characteristics, tumor pr ogression in human PDAC. Methods We performed comprehensive examination using an integrative pathological epidemiology database on 169 cases with resected PDAC . The amount was quantified through digital imaging analysis for Elastica van Gieson-stained...
Abstract Endoscopic papillectomy for early ampullary tumors is considered a minimally invasive and useful alternative to pancreatoduodenectomy; however, its indications remain unclear. This study aimed clarify the advantages of endoscopic by investigating clinical outcomes patients who underwent or pancreatoduodenectomy tumors. Patients diagnosed with (adenoma, Tis, T1a) between June 2008 October 2019 were included, their analyzed. Seventy-four (34 adenomas 40 adenocarcinomas) divided into...
Abstract Background and Aim Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding lobularity, may be associated with severity chronic pancreatitis (CP). However, correlation between parenchymal EUS histology remains unclear. We designed a large‐scale retrospective study analyzing over 200 surgical specimens to elucidate association histological features. Methods Clinical data 221 patients pancreatobiliary tumors who underwent preoperative...
Abstract Background and Aims Imaging tools for predicting pancreatic atrophy after steroid therapy in autoimmune pancreatitis (AIP) have not been established. As delayed equilibrium‐phase contrast enhancement computed tomography (CE‐CT) may reflect interstitial fibrosis, we evaluated the ability of CT imaging atrophy. Methods Forty‐six steroid‐treated AIP patients who underwent contrast‐enhanced at our university hospital were included this retrospective study. attenuation (Hounsfield units...
BACKGROUND:Bouveret syndrome is a rare complication of cholelithiasis that often leads to symptoms gastric outlet obstruction. CASE REPORT:An 84-year-old woman developed acute abdominal due impaction gallstone in the horizontal part duodenum. The diagnosis was supported by computed tomography and double balloon endoscopy. Considering her advanced age position calcified gallstone, we decided perform electrohydraulic lithotripsy using endoscopy for treatment. Finally, impacted stone removed...
A 66-year-old Japanese man was referred to our hospital with multiple giant liver cysts. The cysts had already been detected as 3-cm small nodules at another 12 years prior this presentation. were diagnosed an intraductal papillary neoplasms of the bile duct (IPNB) occupying right lobe liver. Extended lobectomy performed. Based on pathological findings, tumor be oncocytic-type IPNB minimal invasion. This experience suggests that progression IPNBs occur relatively slowly. present case might...
Abstract Pancreatic duct (PD) disruption can be attributed to pancreatic cancer. This study investigated the therapeutic modalities and prognostic implications of PD in retrospective included 16 patients with concomitant cancer between April 2011 March 2023. Of cases disruption, 12, nine, two pseudocysts, infected cysts, walled–off necrosis, respectively. Five underwent endoscopic stenting, nine were managed ultrasonography-guided fluid collection drainage, treated lumen-apposing metal stent...
BACKGROUND:Adenomatous polyposis coli is an autosomal dominant hereditary disorder. Duodenal adenocarcinoma and adenoma, which are extracolonic lesions, not only affect the prognosis of patients but also cause acute pancreatitis. CASE REPORT:We present case a 73-year-old male. He had undergone proctocolectomy for familial adenomatous distal gastrectomy (Billroth II reconstruction with Braun anastomosis) gastric ulcer; he presented pancreatitis caused by ampullary duodenum adenoma....
Abstract Pancreatic cancer primarily arises from microscopic precancerous lesions, such as pancreatic intraepithelial neoplasia (PanIN) and acinar-to-ductal metaplasia (ADM). However, no established method exists for predicting conditions. Endoscopic ultrasonography (EUS) can detect changes in parenchymal histology, including fibrosis. This study aimed to elucidate the relationship between EUS findings lesions. We retrospectively analyzed 114 patients with pancreatobiliary tumors resected...
When the etiology of pancreatitis cannot be determined despite sufficient investigation, recurrence and progression to chronic often involve genetic mutations. Herein, we describe a case recurrent with IVS3+2T>C mutation in serine protease inhibitor Kazal type 1 (SPINK1) gene that progressed only 3 years. A 35-year-old man was referred our hospital, where he diagnosed mild treated conservatively. However, patient experienced episodes pancreatitis, which become pancreatic calcification year...