A5089551666- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
- Renal and related cancers
- Renal Diseases and Glomerulopathies
- Oral Health Pathology and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Amyloidosis: Diagnosis, Treatment, Outcomes
- IgG4-Related and Inflammatory Diseases
- Pancreatic and Hepatic Oncology Research
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Treatments and Mutations
- Hops Chemistry and Applications
- Cancer Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Nuclear Structure and Function
- HIV/AIDS oral health manifestations
- Prostate Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Teratomas and Epidermoid Cysts
- Urological Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Abdominal vascular conditions and treatments
Kobe University
2020-2024
Dokkyo Medical University
2020-2024
Sapporo Kosei General Hospital
2024
Tokyo Women's Medical University Hospital
2023
Kagoshima University
2023
Kagawa Prefectural Central Hospital
2020
Kobe University Hospital
2018-2020
Charles R. Drew University of Medicine and Science
2012
Ehime University
2012
Fukuyama Cardiovascular Hospital
2001
Abstract The objective of this article is to provide a comprehensive overview the imaging characteristics various renal cell tumors using 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET), based on latest WHO-2022 classification. Due physiological accumulation FDG in kidneys, clinical utility FDG-PET evaluation has traditionally been considered limited. However, recent studies have re-evaluated its potential value. demonstrated particular detecting metastases and postoperative...
Thrombospondin type 1 domain-containing 7A (THSD7A) is a recently identified target antigen of idiopathic membranous nephropathy (iMN). The clinicopathological characteristics THSD7A-associated MN are poorly characterised due to low prevalence among patients. Among 469 consecutive cases pathologically confirmed diagnosed at four centres in Japan, 14 were positive for THSD7A by immunohistochemistry (3.0%). tended be higher northern Japan. Most demonstrated nephrotic-range proteinuria (12/14...
Abstract Mutations in p53 are common human oral squamous cell carcinoma (OSCC). However, previous analyses, only detection of mutant protein using immunohistochemistry or mutations some exons have been examined. Full length many cases shows a loss tumor suppressor function, but possibly gain oncogenic function. In this study, we investigate relationships outcomes with the mutational spectrum (missense and truncation mutations) whole exon OSCC. Specimens from biopsy surgery (67 cases) were...
Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 ligand (PD-L1) antibodies, are significantly changing treatment strategies for human malignant diseases, oral cancer. Cancer cells usually escape from the immune system and acquire proliferative capacity invasive/metastatic potential. We have focused on two checkpoints, PD-1/PD-L1 CD47/SIRPα, in tumor microenvironment of squamous carcinoma (OSCC), performed a retrospective analysis expression seven immune-related...
A 79-year-old female was diagnosed with a right renal tumor level II thrombus of the vena cava. presurgical therapy initiated combination avelumab and axitinib for 3 monthes. Then, she underwent nephrectomy thrombectomy. Histologically, primary had no viable cells, indicating that pathological complete response achieved tyrosine kinase inhibitor/Immuno-oncology therapy. An immunohistological xamination showed very strong staining tumor-infiltrating lymphocytes in embolized area tumor, CD8...
The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate during period in which latent/dormant cancer cells become more apparent. To investigate of with OSCC based on individual recurrence and/or metastasis, we performed a retrospective cohort study after complete surgical resection as primary treatment.The was 324 who had been primarily treated surgery from 2007 2020 at our...
Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules m-TKIs vascular endothelial growth factor receptor (VEGF-R). are known to cause adverse reactions such as hypertension proteinuria a class effect. In particular, thought result from damage podocytopathy in glomeruli, development thrombotic microangiopathy (TMA) has been reported...
Administration of cetuximab (C-mab) in combination with paclitaxel (PTX) has been used for patients head and neck squamous cell carcinoma (SCC) clinically. In this study, we attempted to clarify the molecular mechanisms enhancing anticancer effect C-mab combined PTX on oral SCC cells vitro. We two (HSC4, OSC19) A431 cells. alone inhibited growth all a concentration-dependent manner. OSC19 at low concentrations, but HSC4 very weakly, even high concentrations. A drugs was moderate cells,...
Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 ligand (PD-L1) antibodies, are significantly changing treatment strategies for human malignant diseases oral cancer. Cancer cells usually escape from immune system and acquire proliferative capacity invasive/metastatic potential. We have focused on the two checkpoints, PD-1/PD-L1 CD47/SIRPα in tumor microenvironment of squamous carcinoma (OSCC), performed a retrospective analysis expression seven immune-related...
Oral lichen planus (OLP) is a chronic inflammatory mucosal disease, and an apparent cause has not been identified. OLP refractory to treatment, malignant transformation reported. Therefore, discovering effective drugs with few adverse effects over long-term administration crucial. In this study, we established in vitro model investigate the of Cepharanthin®, alkaloid mixture derived from Stephania cephalantha Hayata. Four alkaloids Cepharanthin® suppressed expression cytokine genes at...
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complication caused by antithyroid drugs, particularly propylthiouracil (PTU). Most patients experience organ failure due to the affects of treatment regimen. We herein report case an 89-year-old woman whose severe AAV induced PTU resulted in various instances that eventually led death after 9 years therapy. During autopsy, we identified five types failure. As potentially fatal disease, development symptoms during...
Abstract Background The status of oral cancer therapy in elderly patients Japan, where ageing is rapidly progressing, may serve as a model for other countries with similar demographics. There controversy over what kind treatment should be applied and how aggressively it to very who have exceeded the average life expectancy. Given that 85 years approximately overall Japanese expectancy at birth, we considered threshold hypothesized prognosis squamous cell carcinoma (SCC) aged ≥85 was not...
Background/Aim: Odontogenic diseases are diagnosed based on clinical course, imaging, and histopathology. However, a definitive diagnosis is not always possible. Patients Methods: We analyzed whole exons of SMO, BRAF, PTCH1 GNAS using next-generation sequencing (NGS) in 18 patients. Results: Of the 6 patients with ameloblastoma, 2 had same missense mutation 1 patient peripheral ameloblastoma PTCH1. 7 odontogenic keratocyst, 4 PTCH1, mutations SMO. The odontoma BRAF One cement-osseous...
We report a case of early-stage malignant peripheral nerve sheath tumour (MPNST) found in solitary neurofibroma, and its CT MRI findings. A 19-year-old male with no known history neurofibromatosis presented painless swelling the left forearm. scans showed well-circumscribed, intermuscular mass, which was 6.0 cm diameter contained strongly enhanced 1.0 nodular structure surrounding oedema. Peripheral continuity mass not seen. Histological evaluation proved an MPNST component completely...
Molecules that demonstrate a clear association with the aggressiveness of oral squamous cell carcinoma (OSCC) have not yet been identified. The current study hypothesized tumor cells in OSCC three different origins: Epithelial stem cells, tissue from salivary gland and bone marrow (BM) cells. It was also carcinomas derived less‑differentiated greater malignancy. In present study, sex chromosome analysis by fluorescence <em>in situ</em> hybridization and/or microdissection PCR performed...
TSC-22 (TGF-β stimulated clone-22) has been reported to induce differentiation, growth inhibition, and apoptosis in various cells. is a member of family which many proteins are produced from four different genes. (corresponding TSC22D1-2) composed 144 amino acids translated short variant mRNA the TSC22D1 gene. In this study, we attempted determine intracellular localizations (TSC22D1-1, (TSC22D1-2), TSC22(86) (TSC22D1-3)) identify binding for by mass spectrometry. We determined that...
The main symptom in primary syphilis is a small, painless, sore or ulcer called chancre on the penis, vagina, around anus, although chancres can sometimes appear mouth lips, fingers, buttocks. We present case of man his early 60 s with chief complaint painful tongue ulcer. An ulcerated, indurated, and hemorrhagic lesion (23 × 14 mm) was found ventral surface, near oral floor. Palpation identified several swollen, mobile, elastic cervical lymph nodes, no tenderness. initially diagnosed...
Key Clinical Message Renal cell carcinoma as a secondary malignant neoplasm is relatively rare; however, the possibility of renal following chemoradiotherapy for childhood nephroblastoma should be considered. Abstract The occurrence (RCC) rare, especially in microphthalmia transcription factor family translocation carcinoma. A 13‐year‐old Japanese male was referred to our department treatment right kidney mass. patient had undergone open left nephrectomy and adjuvant chemotherapy...
Tubulointerstitial nephritis (TIN) has various etiologies, including IgG4-related disease (IgG4-RD), autoimmune diseases, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), and others. IgG4-positive plasma cell infiltration can occasionally be found in TIN unrelated to IgG4-RD. Therefore, there may problems with usage of IgG4 immunostaining differentiate between without This study aimed compare the proportion cells that are positive for each IgG subclass clarify...
Abstract Purpose To compare the image quality, inter-reader agreement, and diagnostic capability for muscle-invasive bladder cancer (MIBC) of reconstructed images in sections orthogonal to tumor obtained by 3D Dynamic contrast-enhanced (DCE)-MRI using Golden-angle Radial Sparse Parallel (GRASP) technique with directly captured Cartesian sampling. Materials methods This study involved 68 initial cases examined DCE-MRI (GRASP: n = 34, Cartesian: 34) at 3 Tesla. Four radiologists conducted...
Renal cell carcinoma (RCC) occasionally has sarcomatoid differentiation and rarely contains heterologous components. We report a case of chromophobe RCC with that had various components including unique lipomatous area. The patient was an 83‐year‐old woman palpable mass in the left lower abdomen. Grossly, tumor 14 cm diameter yellowish‐to‐whitish color focal necrosis hemorrhage. Histologically, composed eosinophilic subtype mainly chondrosarcoma, some osteosarcoma are usually or multiple is...
A 77-year-old man was referred to our hospital with persistent proteinuria and progressive lower leg edema. Past history unremarkable except for hypertension. Autoimmune diseases, infections, malignancies were excluded based on clinical laboratory test results. Renal biopsy specimens showed membranous nephropathy segmental distribution of spikes bubbling appearance. Double contour formation in glomerular tufts also observed. There no proliferative changes the glomeruli. Interstitial fibrosis...