A5101988318- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Urological Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Dental Implant Techniques and Outcomes
- Erythrocyte Function and Pathophysiology
- Bone Tumor Diagnosis and Treatments
- Blood groups and transfusion
- Tissue Engineering and Regenerative Medicine
- Veterinary Pharmacology and Anesthesia
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- RNA modifications and cancer
- Glycogen Storage Diseases and Myoclonus
- Heterotopic Ossification and Related Conditions
- Acute Kidney Injury Research
- Veterinary Oncology Research
- Immunodeficiency and Autoimmune Disorders
- Bipolar Disorder and Treatment
- IgG4-Related and Inflammatory Diseases
- Cancer Cells and Metastasis
- Nasolacrimal Duct Obstruction Treatments
- Biomedical Research and Pathophysiology
The University of Tokyo
2012-2025
Veterinary Medical Center
2025
Obayashi (Japan)
2021
Dokkyo Medical University
2018-2021
Kwansei Gakuin University
2003-2021
National Institute of Diabetes and Digestive and Kidney Diseases
2018
National Heart Lung and Blood Institute
2018
Nippon Medical School
2013-2014
National Institutes of Health
2014
Asahi University
1998
Sialic acid, a common terminal substitution of glycoconjugates, has been so far consistently identified in all vertebrates as well growing number bacterial species. It is assumed to be widely distributed among animal species the deuterostome phylum, based on its identification few echinoderm and vertebrate However, whole sections deuterostome, especially those intermediate between invertebrates including cephalochordates, urochordates hemichordates, are still unexplored term sialylation...
The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate during period in which latent/dormant cancer cells become more apparent. To investigate of with OSCC based on individual recurrence and/or metastasis, we performed a retrospective cohort study after complete surgical resection as primary treatment.The was 324 who had been primarily treated surgery from 2007 2020 at our...
In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current methods are encumbered by modest transduction rates and high baseline fetal production. this study, we sought improve both modification production among in vitro. To model therapeutic strategies, transduced CD34+ peripheral blood mononuclear (PBMCs) with lentiviral vectors compared erythropoietin-based using fetal-bovine-serum-containing media...
A retrospective cohort study was performed to investigate the effectiveness of preemptive postsurgical therapy with cetuximab for patients a major risk recurrence or metastasis after clinical complete resection primary oral squamous cell carcinoma (OSCC). The period from 2007 2019 treated at Department Oral and Maxillofacial Surgery, Dokkyo Medical University School Medicine. OSCC (n = 88) in follow-up were divided into groups no treatment (NP group), standard (SP including (CP prognosis...
Abstract Background The status of oral cancer therapy in elderly patients Japan, where ageing is rapidly progressing, may serve as a model for other countries with similar demographics. There controversy over what kind treatment should be applied and how aggressively it to very who have exceeded the average life expectancy. Given that 85 years approximately overall Japanese expectancy at birth, we considered threshold hypothesized prognosis squamous cell carcinoma (SCC) aged ≥85 was not...
We previously reported that some L1 family (KpnI family) members are closely associated with the Alu sequence. To understand details of L1-Alu association, structure a unit downstream from beta-globin gene was compared between human and primates. The results revealed L1-Alu-associated sequence formed by insertion sequence, T beta G41, into 3' poly A tract preexisting It estimated G41 inserted after divergence Old World monkeys hominoids before orang-utan common ancestor other higher...
Abstract Osteoblastic cells are a key component of the bone marrow (BM) stem cell niche and help regulate hematopoietic (HSCs). We have previously demonstrated that adipose‐derived stromal (ADSCs) can differentiate into both osteogenic chondrogenic in vitro. The current study examined whether anatomical architecture BM could be regenerated vivo by using ADSCs cultured on hydroxyapatite (HA) scaffold. from GFP transgenic mice were vitro an HA scaffold with attached was implanted...
Molecules that demonstrate a clear association with the aggressiveness of oral squamous cell carcinoma (OSCC) have not yet been identified. The current study hypothesized tumor cells in OSCC three different origins: Epithelial stem cells, tissue from salivary gland and bone marrow (BM) cells. It was also carcinomas derived less‑differentiated greater malignancy. In present study, sex chromosome analysis by fluorescence <em>in situ</em> hybridization and/or microdissection PCR performed...
TSC-22 (TGF-β stimulated clone-22) has been reported to induce differentiation, growth inhibition, and apoptosis in various cells. is a member of family which many proteins are produced from four different genes. (corresponding TSC22D1-2) composed 144 amino acids translated short variant mRNA the TSC22D1 gene. In this study, we attempted determine intracellular localizations (TSC22D1-1, (TSC22D1-2), TSC22(86) (TSC22D1-3)) identify binding for by mass spectrometry. We determined that...
A 13-year-old, neutered male miniature dachshund was presented with a one-month history of bilateral symmetrical swelling in the pinnae and carpal, cubital tarsal joints, tail. The lesions were histopathologically characterized by multiple dilated lymphatic vessels lined single attenuated layer endothelial cells. subcutis predominantly involved. number spindle-shaped cells lining irregular observed. Morphological atypia not evident these Immunohistochemical analyses revealed that...
We characterized the Ca2+-independent, membrane-associated phospholipase A2 (PLA2) from rat parotid secretory granules. Among four phosphatidylcholine species with different fatty acyl (palmitoyl, oleoyl, linoleoyl, and arachidonoyl) groups at sn-2 position, 2-arachidonoyl-phosphatidylcholine was preferred substrate. Such specificity also apparent even when coexisted another species. The various well-documented inhibitors of PLA2s, bromoenol lactone, arachidonyl trifluoromethyl ketone,...
Introduction: Adenomatoid odontogenic tumor (AOT) is a rare of epithelial origin, and usually presents as unilocular radiolucency in the maxillary anterior region adolescent females. Observation: A 31-year-old Japanese male, having large adenomatoid from right molar to left mandible showing root resorption neighboring teeth, was presented hospital. The lesion totally resected under general anesthesia. Commentary: AOT may cause displacement teeth. But very finding. AOTs are relatively small...
Urinary tract diseases are common in cats, and often require surgical reconstruction. Here, to explore the possibility of urinary reconstruction cats using in-vivo tissue architecture (iBTA), biosheets fabricated iBTA technology were implanted into feline bladder regeneration process was histologically evaluated. The prepared by embedding molds dorsal subcutaneous pouches six for 2 months. A section wall removed, sutured excision site. After 1 3 months implantation, harvested evaluated...
Urinary tract diseases are common in cats, and often require surgical reconstruction. Here, to explore the possibility of urinary reconstruction cats using in-body tissue architecture (iBTA), biosheets fabricated iBTA technology were implanted into feline bladder regeneration process was histologically evaluated. The prepared by embedding molds dorsal subcutaneous pouches six for 2 months. A section wall removed, sutured excision site. After 1 3 months implantation, harvested evaluated...
Abstract Reactive bone growth is often clinically difficult to distinguish from true tumors, and both types of lesion are frequently lumped together as “osteomas.” We carried out surgical resection an osteoma on the inferior border mandible a patient with no history mechanical stimulus or trauma that showed autonomous over time imaging assessments. were therefore considered this tumor, report case discussion literature. It important resect lesions sufficient safety margin when classified...
Abstract Background The present study examined the effectiveness of high-purity macro/microporous beta-tricalcium phosphate (HPMM β-TCP) as a bone grafting material for maxillary sinus floor elevation by morphometric, histopathological, and histomorphometric evaluations. Methods Ten unilateral procedures using 100% HPMM β-TCP were performed in 10 patients. Morphometric evaluation was carried out computed tomography (CT) imaging immediately after augmentation prior to dental implant placement...
This paper reports a rare case of Fordyce's spot with cyst formation in the buccal mucosa. The patient was 71-year-old Japanese male who noticed painless swelling surrounded by right elliptical shape, 2mm diameter, and had yellowish surface. We excised over buccinators muscle. specimen examined histopathologically diagnosed as formation. No recurrence has been observed.