Little information is available on the relationship between computed tomography ( CT ) imaging findings and pathologic diagnosis of canine hepatic tumors. Our purpose was to clarify characteristic features in liver tumors dogs. Data from 33 dogs with either a hepatocellular carcinoma, n = 14, adenoma, or nodular hyperplasia, 5 were summarized medical records. for each histologic characterized analyzed statistically. Common carcinoma included central (79%, P 0.0030) marginal enhancement (93%,...

Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models necessary improve our understanding progression, diagnosis, treatment iUC. Companion canines are preferred model iUC due spontaneous tumor development similarity human disease terms histopathology, metastatic behavior, response. However, the comprehensive molecular characterization canine...

Although regulatory T cells (Tregs) play an integral role in immunologic tolerance and the maintenance of intestinal homeostasis, their involvement canine gastrointestinal diseases, including idiopathic inflammatory bowel disease (IBD) lymphoma, remains unclear. Here we show altered numbers forkhead box P3 (Foxp3)-positive Tregs intestine dogs with IBD lymphoma. was diagnosed 48 dogs; small cell lymphoma 46 large 30 25 healthy beagles were used as normal controls. Foxp3-positive duodenal...

The rapid growth in aging populations has made prevention of age-related memory decline and dementia a high priority. Several epidemiological clinical studies have concluded that fermented dairy products can help prevent cognitive decline; furthermore, intake Camembert cheese prevents microglial inflammation Alzheimer’s pathology mouse models. To elucidate the molecular mechanisms underlying preventive effects products, we screened peptides from digested milk protein for their potential to...

The development of protein-specific antibodies is essential for understanding a wide variety biological phenomena. Parasitic and viral infections cancers are known to occur within California sea lion (Zalophus californianus) populations. However, sensitive specific monoclonal (mAbs) the pathophysiological analysis tissues have not yet been developed. A type I transmembrane glycoprotein, podoplanin (PDPN), diagnostic marker lymphatic endothelial cells. We previously developed several...

The relationship between cerebral lesions such as amyloid angiopathy or senile plaques and deposition in the visceral organs were studied 90 autopsy cases of dogs, 0 to 19-year-old. Cerebral was detected 28 aged dogs (mean age: 13.7-year-old) found mostly around wall meningeal arterioles capillaries neocortex. That condition often accompanied by hemorrhage more than 9 years age. Senile neocortex brain 12 13.2-year-old) classified into 3 subtypes, i.e., "diffuse plaque", "primitive plaque"...

In dogs, there are several idiopathic meningoencephalitides, such as necrotizing meningoencephalitis (NME), leukoencephalitis (NLE), and granulomatous meningoencephalomyelitis (GME). Although they often assumed to be immune mediated, the etiology of these diseases remains elusive. this study, histopathology lesions caused by conditions inflammatory cell populations produced in response them were examined among dogs affected with GME, NME, or NLE understand their pathogeneses. The brain...

Canine histiocytic sarcoma (HS) is a rare neoplasm that originates from dendritic cells or macrophages, and there have been number of cases experienced in Japan. To identify the characteristics prognostic variables determine outcome dogs with HS Japan, medical records 73 were retrospectively analyzed. Signalment, clinical signs, complete blood count (CBC), chemistry profiles, treatment, response to treatment overall survival (OS) Diagnosis was determined histologically 44 cytologically 29...

A 5 yr old chihuahua presented to our clinic with a complaint of decreased activity and focal seizures. Based on the findings MRI computed tomography, primary brain tumor originating from right frontal lobe region was suspected. Surgical resection performed, diagnosis histiocytic sarcoma made via histopathological examination immunohistochemical staining. Low-dose 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (45 mg/m2 every 4-5 wk) started postoperatively, no apparent recurrence found...

A 6-year-old, intact female cat presented with sudden collapse. Clinical examinations indicated severe regenerative anemia and a large abdominal mass containing fluid. An exploratory laparotomy revealed cystic lesion at the cranial end of right uterine horn. Ovariohysterectomy was performed, made full recovery. The contained blood clot 102 mL blood. Histological examination confirmed that hemorrhagic located within fallopian tube. thickened uterus vasodilation histologically diagnosed as...

Introduction Intracranial dermoid cysts (IDCs) are rarely observed in veterinary medicine, and reports regarding treatment strategies for feline IDCs severely lacking. This report describes the surgical management of epileptic seizures caused by a cat. Case presentation An 8-year-old, spayed, female American Shorthair cat presented with seizures. The seizures, which had developed at age 5 years, been controlled phenobarbital administration. At 8 years old, contracted acute hepatitis,...

A 5-year-4-month-old neutered female French bulldog had a brain mass that was surgically excised. Histologically, the tumor consisted of neoplastic oligodendroglial and spindle-shaped cells, chondroid tissues. Immunohistochemically, cells were immunopositive for oligodendrocyte transcription factor 2 (OLIG2), 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), platelet-derived growth receptor alpha (PDGFRA), vimentin, cluster differentiation 44 (CD44), WW domain containing regulator 1...

The factors affecting the quality of histopathologic specimens obtained via small intestinal endoscopic biopsy (SIEB) remain unclear. To identify related to SIEB. Histopathologic duodenal and ileal were from 116 dogs 38 cats that underwent SIEB for diagnostic purposes. This retrospective study analyzed 3354 individual scored using grading system adequacy (GSHA). A lower GSHA score indicates specimens. Univariate multivariate ordinal logistic models used assess relationship between various...

Canine necrotizing meningoencephalitis (NME) and granulomatous meningoencephalomyelitis (GME) were compared pathologically. Gross observation exhibited lateral ventricular dilation discoloration, malacia and/or cavitation of the cerebrum in NME. On contrary, gross changes milder GME, except for occasional visible mass formation. Histopathologically, lesions NME distributed predominantly cerebral cortex various degrees inflammatory necrotic observed according to clinical stages. Besides,...

A total of 12 clinically ill cats previously diagnosed as feline infectious peritonitis (FIP) were treated with a combination recombinant interferon and glucocorticoid. complete remission (over 2 years) partial (2 to 5 months) observed in four (33.3%) cases, respectively. Those that survived for more than years all older (6 16 old) the effusive form FIP.

Medical records of dogs with colorectal polyps were retrospectively reviewed, and clinical presentation inflammatory in miniature dachshunds was evaluated. Of 33 found to have polyps, markedly over-represented 16 (48%), which 12 (75%) polyps. Multiple localized between the rectum descending colon most common finding Twenty (80%) out 25 responded immunosuppressive therapy using prednisolone cyclosporine. The results this study indicate that are predisposed develop multiple for may be a...

Background Although immunoglobulin A (IgA) plays a key role in regulating gut homeostasis, its canine inflammatory bowel disease ( IBD ) is unknown. Hypothesis IgA expression may be altered dogs with , unlike that observed healthy and other gastrointestinal diseases. Animals Thirty‐seven 10 intestinal lymphoma, 20 dogs. Methods Prospective study. IgG concentrations serum, feces, duodenal samples were measured by ELISA. + cells lamina propria CD21 peripheral blood mononuclear PBMC s) examined...

Regulatory T cells (Tregs) infiltrate into a variety of tumour tissues and associate with poor prognosis in humans. However, data on association Treg infiltration is limited canine tumours. The purpose this study was to examine the number tumour-infiltrating Tregs its overall survival (OS) dogs malignant following 168 tumours were included: 37 oral melanomas (OMMs); 14 squamous cell carcinomas (OSCCs); 16 pulmonary adenocarcinomas (PAs); mammary (MCs); 36 mast (MCTs) 28 hepatocellular...

Histiocytic sarcoma is a progressive and fatal malignant neoplasm that mainly occurs in middle- to old-aged dogs. This study describes clinicopathological, histological immunohistochemical characteristics of intracranial histiocytic sarcomas 23 Magnetic resonance imaging and/or computed tomography the brains revealed tumors located cerebrum, particularly frontal lobe. Seizure was predominant clinical sign most cases. Histologically, tumor cells were morphologically classified into...

The protective property of propolis across a wide spectrum diseases has long been realized, yet the anti-tumor efficacy this bioactive substance from Philippine stingless bees remained poorly understood. Here, we showed tumor-suppressing potential crude ethanolic extract bee (EEP) in vitro models gastric cancer highlighting first indication remarkable subtype specificity towards differentiated-type human cell lines but not diffuse-type. Mechanistically, involved profound modulation several...

Necrotizing meningoencephalitis (NME), necrotizing leukoencephalitis (NLE), and granulomatous meningoencephalomyelitis (GME) are idiopathic inflammatory diseases in the central nervous system (CNS) of dogs. In our previous study, proportion cells, except for CD3-positive T were not different parenchymal perivascular lesions brain. However, breed specificities, clinical courses, specific distinct among these diseases. Thus, similarities differences pathologies have been implied. this...