A5086535576- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Particle Accelerators and Free-Electron Lasers
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Advanced materials and composites
- Veterinary Oncology Research
- Superconducting Materials and Applications
- Radiation Detection and Scintillator Technologies
- Particle accelerators and beam dynamics
- Shape Memory Alloy Transformations
- Intermetallics and Advanced Alloy Properties
- Alzheimer's disease research and treatments
- Virus-based gene therapy research
- Neurological diseases and metabolism
- Medical Imaging Techniques and Applications
- Magnetic Properties of Alloys
- Hedgehog Signaling Pathway Studies
- Prion Diseases and Protein Misfolding
- Animal Virus Infections Studies
- Advanced Polymer Synthesis and Characterization
- Dark Matter and Cosmic Phenomena
- Metal and Thin Film Mechanics
- Advanced ceramic materials synthesis
- Amyloidosis: Diagnosis, Treatment, Outcomes
High Energy Accelerator Research Organization
2006-2024
Max Planck Institute for Physics
2023-2024
Ibaraki University
2018-2024
National Institute of Advanced Industrial Science and Technology
2011-2024
Osaka University of Pharmaceutical Sciences
2014-2024
The Graduate University for Advanced Studies, SOKENDAI
2019-2023
The University of Tokyo
2012-2022
University of Bonn
2022
Hyogo Prefectural Amagasaki General Medical Center
2022
Shibuya (Japan)
2022
The SuperKEKB project requires a positron and electron collider with peak luminosity of 8 × 1035 cm−2 s−1. This is 40 times that the KEKB B-factory, which operated for 11 years up to 2010. an asymmetry-energy double-ring collider; beam energy (LER) 4 GeV (HER) 7 GeV. An extremely small beta function at interaction point (IP) low emittance are necessary. In addition, in order achieve target luminosity, large horizontal crossing angle between two colliding beams adopted, as bunch length much...
Gastric cancer (GC) is one of the most common malignancies worldwide. Genes whose expression down-regulated in GC may be tumour suppressor genes. In present study, genes with decreased were screened for by serial analysis gene (SAGE) data and reverse transcription (RT)-polymerase chain reaction (PCR), CLDN18 (encoding claudin-18) was identified. Quantitative RT-PCR revealed that 13 (56.5%) 23 GCs. Immunostaining showed normal gastric mucosa Paneth cells duodenum expressed claudin-18 on cell...
We have performed ab-initio total energy calculations for the system of BaTiO 3 doped with d transition metal (from Sc to Cu), within framework local spin-density approximation (LSDA). Total energies corresponding nonmagnetic, ferromagnetic, and anti-ferromagnetic configurations magnetic ordering were calculated examine stability. The results predict that Cr-, Mn-, Fe-doped are candidates ferromagnetic fabrication. Above all, Mn-doped is most promising, although carrier doping necessary.
Scientific Report7 March 2014Open Access Source Data Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2 Yasunori Shintani Corresponding Author William Harvey Research Institute, Barts and The London School Medicine Dentistry, Queen Mary University London, UK Department Medical Biochemistry, Osaka Graduate Medicine, Suita, Japan Search for more papers this author Hannes CA Drexler Bioanalytical Mass...
LRIG1, a membrane glycoprotein, has emerged as significant stem cell marker and negative regulator of receptor tyrosine kinases (RTKs), including EGFR. Glycosylation is major post-translational modification, which plays crucial role in protein function stability. In cancer biology, abnormal glycosylation can serve biomarker contribute to pathogenesis. We aimed investigate the effects on LRIG1 functions. Through database analysis experimental approaches, we focused evolutionarily conserved...
First experimental results from the final focus test beam (FFTB) are reported. The vertical dimension of a 47-GeV electron SLAC linac has been reduced at focal point FFTB by demagnification 320 to height approximately 70 nm.
The expression of cell differentiation and proliferation markers canine neuroepithelial tumors was examined immunohistochemically to identify the histogenesis these tumors. Astrocytomas (n = 4) consisted cells positive for glial fibrillary acidic protein (GFAP) nestin a few doublecortin (DCX). Immunoreactive receptor tyrosine kinases (epidermal growth factor c-erbB2) their downstream molecules (phospho-extracellular signal-regulated kinase 1/2 phospho-Akt) were often detected in...
Subdural histiocytic sarcomas from 15 dogs (mean age 7.8 years) were histopathologically examined. Among the dogs, there was a marked breed predominance (toward Pembroke Welsh Corgi 47%), but no gender predilection. Focal solitary subdural masses detected in cerebrum (12 cases) and spinal cord (1 case), whereas diffuse infiltrative lesions observed cerebral leptomeninges 2 cases. All neoplastic had common histological features characterized by proliferation of pleomorphic cells combined with...
Senile plaques (SPs) and cerebral amyloid angiopathy (CAA), pathological hallmarks of Alzheimer's disease, have not been thoroughly investigated histopathologically in nonhuman primates. To determine the onset age histopathological characteristics SPs CAA, we examined brains 64 cynomolgus monkeys ( Macaca fascicularis ) from 2 to 35 years old. Mature (classical primitive) appeared 16 out 25 that were >20 Moreover, mature observed more frequently than diffuse located temporal cortex...
Tumor necrosis factor alpha (TNF-alpha) induced morphologic changes such as chromatin condensation and cell shrinkage in a feline fibroblastic line (CRFK) chronically infected with immunodeficiency virus (FIV) but not uninfected CRFK cells. DNA extracted from TNF-alpha-treated cells FIV showed ladder of nucleosomal DNA, indicating that this cytocidal effect by TNF-alpha was due to programmed death, or apoptosis. These findings may have implications for understanding the pathogenesis...
Canine malignant peripheral nerve sheath tumors (MPNSTs) occur not only in the nervous system (PNS) but also soft tissue and various organs (non-PNS). The most important diagnostic criterion is proof of origin. This difficult non-PNS MPNSTs, its differential diagnosis challenging. perivascular wall (PWTs) commonly arise tissue. Their histopathological features are quite similar to those canine making their To elucidate whether morphological applicable diagnose MPNSTs demonstrate useful...
Regulatory T cells (Tregs) infiltrate into a variety of tumour tissues and associate with poor prognosis in humans. However, data on association Treg infiltration is limited canine tumours. The purpose this study was to examine the number tumour-infiltrating Tregs its overall survival (OS) dogs malignant following 168 tumours were included: 37 oral melanomas (OMMs); 14 squamous cell carcinomas (OSCCs); 16 pulmonary adenocarcinomas (PAs); mammary (MCs); 36 mast (MCTs) 28 hepatocellular...